Liver Involvement in Congenital Hypopituitarism.

Abstract:

OBJECTIVE:Cholestatic jaundice in early infancy is a complex diagnostic challenge. Cholestasis caused by endocrine disease is rare and poorly recognized. The aim of this paper is to report patients with liver dysfunctions resulting from hypopituitarism. METHODS:Six patients with liver dysfunction diagnosed as hypopituitarism were studied and followed up at Uludag University Faculty of Medicine. RESULTS:The median age of the patients at first presentation was 2.5 mo. Three patients were diagnosed with congenital hypopituitarism at the first visit, and the other three were diagnosed during follow-up. Serum aminotransferase levels were very high in two patients and only moderately elevated in the others. Combined adrenal, thyroid, and growth hormone deficiencies were diagnosed in two patients, while remaining 4 patients had various combinations of adrenal, thyroid, and growth hormone deficiencies. Liver function abnormalities resolved between 10 d and 2 mo follow-up after hormone replacement therapy. CONCLUSIONS:Abnormal liver biochemical test results due to hormonal deficiencies in infants should be considered in the differential diagnosis by pediatricians. Hormone replacement therapy is the basis of treatment.

journal_name

Indian J Pediatr

authors

Altay D,Eren E,Ozkan TB,Ozgur T,Tarım O

doi

10.1007/s12098-018-2833-7

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

412-416

issue

5

eissn

0019-5456

issn

0973-7693

pii

10.1007/s12098-018-2833-7

journal_volume

86

pub_type

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