Abstract：
:Prostaglandin E2 (PGE2) is a critical factor in the pathogenesis of dioxin-induced neonatal hydronephrosis. Since the PGE2 receptor has four subtypes, EP1 - EP4, this study was aimed to challenge the hypothesis that at least one of the four subtypes is responsible for the pathogenesis of dioxin-induced hydronephrosis. To this end, we used mouse pups, with a C57BL/6 J background, genetically lacking EP1, EP2, or EP3, and wild-type pups in whom EP4 was suppressed by administering ONO-AE3-208 (ONO), an EP4 antagonist, from postnatal day 1 (PND 1) to PND 13. To expose the pups to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) via lactation, the dams were administered TCDD at an oral dose of 20 μg/kg on PND 1. The pups' urine and kidneys were collected on PND 14 for urinalysis and histological examination, respectively. We found that the incidence of hydronephrosis was 80% in the EP1+/+ group, but was markedly reduced to 28.6% in the EP1-/- group despite the fact that PGE2 concentration in the urine was similarly increased in the both groups. In contrast, the incidence of hydronephrosis was 80% and 100% in the EP2+/+ and EP2-/-groups, respectively, and 88.9% and 100% in the EP3+/+ and EP3-/- groups, respectively. With regard to EP4, the incidence of hydronephrosis in vehicle (saline)-treated groups and ONO-treated was 88.9% and 100%, respectively. Therefore, we concluded that among PGE2 receptor subtypes, EP1 plays a predominant role in the onset of TCDD-induced neonatal hydronephrosis in mouse pups.
journal_name
Toxicologyjournal_title
Toxicologyauthors
Aida-Yasuoka K,Nishimura N,Fujisawa N,Endo N,Narumiya S,Tohyama Cdoi
10.1016/j.tox.2019.01.006subject
Has Abstractpub_date
2019-03-01 00:00:00pages
10-17eissn
0300-483Xissn
1879-3185pii
S0300-483X(18)30354-8journal_volume
415pub_type
杂志文章相关文献
TOXICOLOGY文献大全abstract：:Extract and fractions of city smog collected from a heavy industrialized area caused in vitro dose-dependent reduction of cell survival of mouse macrophages and a growth inhibition of human fetal diploid lung fibroblasts. Great differences were observed in both cell systems between the total extract and its different ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(80)90091-8
更新日期：1980-01-01 00:00:00
abstract：:In 1975, in cooperation with 8 County Hygienic Stations, total mercury content in fish from rivers and lakes in Hungary was measured. The mercury content in fish muscle-tissue from 164 fish samples averaged 0.36 mg/kg. Average levels in different fish species ranged from 0.10 to 0.57 mg/kg. The amount of mercury in fi...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(77)90052-x
更新日期：1977-06-01 00:00:00
abstract：:The use of colchicine-specific Fab fragments is of interest in human poisoning. In the present study, we show the efficacy of Fab fragments in reversing colchicine toxicity in mice. High affinity antibodies (Ka = 2 x 10(10) M-1) against colchicine were raised in goats; Fab fragments were purified by DEAE chromatograph...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(91)90015-s
更新日期：1991-01-01 00:00:00
abstract：:The effect of mangiferin, a naturally occurring xanthone glucoside on cyclophosphamide-induced immunotoxicity and its mode of action in the immune system were investigated. To induce immunotoxicity, adult male Wistar rats were injected weekly with cyclophosphamide intraperitoneally at 100 mg/kg bodyweight. Mangiferin ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2005.06.008
更新日期：2005-11-05 00:00:00
abstract：:In inhalation chambers, male Wistar rats of the strain TNO-W74 were continuously exposed to submicron aerosols of sodium dichromate and to a pyrolyzed Cr(VI)/Cr(III) (3:2) oxide mixture. The sodium dichromate (Na2Cr2O7) aerosol had the chromium concentrations of 25, 50 and 100 micrograms/m3, the chromium oxide mixture...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(86)90011-9
更新日期：1986-12-15 00:00:00
abstract：:Gordonia axillaris (Roxb.) Dietrich (Theaceae) is a native to Taiwan and the leaves have been used as an astringent folk medicine. Camelliin B (CB), a macrocyclic hydrolyzable tannin, was isolated from G. axillaris and showed cytotoxic effects in human carcinoma cells. Among the target cells (SKHep-1, Ha-22T, DU-145, ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(01)00452-8
更新日期：2001-11-30 00:00:00
abstract：:Measurement of lymphocyte proliferation to detect hypersensitivity to beryllium (Be-LPT) in vitro is done presently using a method based on tritiated thymidine incorporation. Although this method is sensitive it gives no information on cell viability or responding lymphocyte subsets. We have developed reliable and sim...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(99)00167-5
更新日期：2000-02-21 00:00:00
abstract：:The use of zinc as a nutritional supplement has become common in many countries. Since zinc has diverse actions, it may be difficult to predict its synergistic and/or antagonistic action in simultaneous presence of drug(s). The combination of imidazole antifungals, but not triazole antifungals, with 3-30 microM ZnCl2 ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2008.03.022
更新日期：2008-06-27 00:00:00
abstract：:As vaccines are undoubtedly classified as pharmaceuticals, they have to be submitted to strict non-clinical safety evaluation. The context of their prophylactic use requires that every effort is made to ensure their safe use. Their safety evaluation is complex as they act through a multistage mechanism in which the va...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/s0300-483x(02)00055-0
更新日期：2002-05-15 00:00:00
abstract：:The effect of tert-butyl hydroperoxide (tBH) on the nucleotide level in isolated cardiomyocytes from adult rats was examined. Incubation of myocytes with the hydroperoxide resulted in loss of both ATP and NAD from mitochondria and cytosol. In contrast, only the cytosolic level of NADP was increased. The effect on myoc...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(95)03158-c
更新日期：1996-01-08 00:00:00
abstract：:Neonatal rat hearts were separated into separate cultures of beating myocytes (M cells), endothelial cells (E cells) and fibroblasts (F cells). Their susceptibilities to the toxic effects of emetine, chloroquine and metronidazole were then compared using a quantitative metabolic inhibition test (QMIT) and morphologic ...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(84)90066-0
更新日期：1984-11-01 00:00:00
abstract：:We performed a reporter gene assay for ERalpha-mediated transcriptional activation and an immature rat uterotrophic assay of 23 chemicals, to study the relationship between these two assays and to examine the usefulness of the reporter gene assay. The chemicals analyzed in the study were as follows: benzophenone, bisp...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(01)00505-4
更新日期：2002-01-15 00:00:00
abstract：:Chemicals can increase carcinogenic risk by either directly damaging DNA or increasing cell replication or they can do both. These effects have different implications for a biologically-based extrapolation from rodent bioassays to humans. 2-Acetylaminofluorene (2-AAF) administered at low doses to mice for a lifetime h...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/0300-483x(95)03044-g
更新日期：1995-09-01 00:00:00
abstract：:Chlorpyrifos (CPF) has been widely used around the world as a pesticide for both agricultural and residential application. Although various studies have reported toxicity and health-related effects from CPF exposure, the molecular mechanism of CPF toxicity to skin has not been well-characterized. The present study det...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2015.09.006
更新日期：2015-12-02 00:00:00
abstract：:Evidence from epidemiological studies indicates that acute exposure to airborne pollutants is associated with an increased risk of morbidity and mortality attributed to cardiovascular diseases. The present study investigated the effects of combustion-derived ultrafine particles (diesel exhaust particles) as well as en...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2008.08.018
更新日期：2008-11-20 00:00:00
abstract：:A number of clinical reports and experimental studies have shown that autoimmune responses and/or autoimmune diseases are induced in humans and laboratory animals by chronic exposure to various chemicals. The present review is focused on the most frequent groups of chemically induced human disorders. Results obtained ...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/s0300-483x(96)03591-3
更新日期：1997-04-11 00:00:00
abstract：:Cyclophosphamide (CP) is a known immunomodulating agent. When presented to either late stage chick embryos (e.g. 18 days of incubation (DI] or neonatal chicks. CP induces selective B cell damage resulting in humoral immunosuppression in chickens. The present study was undertaken in order to provide further insights in...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(91)90196-8
更新日期：1991-03-11 00:00:00
abstract：:Repeated intraperitoneal administration of benzene (1.0 ml/kg body wt) for 3 days produced leucopenia, lymphocytopenia and an increased number of nucleated cells in the bone marrow and significantly decreased organ weights of thymus (P less than 0.001) and spleen (P less than 0.001) in female albino rats. Iron content...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(86)90029-6
更新日期：1986-06-01 00:00:00
abstract：:Recently we observed a suppressed delayed-type hypersensitivity (DTH) response to bovine serum albumin (BSA) in the 4-5-month-old offspring of F344 rat dams receiving as little as 1.0 microg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)/kg on gestational day (GD) 14. This study was designed to characterize better this su...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(99)00024-4
更新日期：1999-05-03 00:00:00
abstract：:Benzene, an important industrial solvent, is also present in unleaded gasoline and cigarette smoke. The hematotoxic effects of benzene in humans are well documented and include aplastic anemia and pancytopenia, and acute myelogenous leukemia. A combination of metabolites (hydroquinone and phenol for example) is appare...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(95)03217-4
更新日期：1995-12-28 00:00:00
abstract：:The zebrafish Danio rerio embryo test with metabolic activation (mDarT) was developed to assess the teratogenic effects of proteratogens. In this study induced rat liver microsomes (RLM) were used as a mammalian metabolic activation system (MAS), since they contain various cytochrome P450 (CYP) isoforms at high concen...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2010.05.012
更新日期：2010-09-10 00:00:00
abstract：:Colicins are unusual bacterial toxins because they are directed against close relatives of the producing strain. They kill their targets in one of three distinct ways; via a ribonuclease or deoxyribonuclease activity or by forming pores in the target cell's membrane. This review deals with the steps involved in pore-f...
journal_title：Toxicology
pub_type： 杂志文章,评审
doi：10.1016/0300-483x(94)90156-2
更新日期：1994-02-28 00:00:00
abstract：:Alkylfurans inflict toxicity in several mammalian species to lung, liver and kidney. Organ specificity of the alkylfurans is a sensitive function of the nature of the alkyl group. To determine if this toxicity requires an aromatic ring in the compound, we synthesized 4-methyl-2,3-dihydrofuran, 4-ethyl-2,3-dihydrofuran...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(90)90006-3
更新日期：1990-03-30 00:00:00
abstract：:Several inhibitors of cytochrome P-450 mediated oxidative transformations, ethyl 2-diethylaminoethyl-2-phenyl-2-ethylmalonate, ethyl-2-diethyl-aminoethyl-2-ethyl-2-buthylmalonate, 2,4 dichloro-6-phenoxyethyl diethylamine, 2-diethylaminoethyl-2-phenyl- (2-propene)-4-penten-1-oate or 3-amino,1,2,4 triazole were not able...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(80)90117-1
更新日期：1980-01-01 00:00:00
abstract：:Insulin and dexamethasone are potent inhibitors of apoptosis induced by transforming growth factor-beta1 (TGF-beta) in hepatoma cells. Using FTO-2B rat hepatoma cells, we determined whether the anti-apoptotic effects of these agents result from interference within or upstream of the TGF-beta-induced caspase cascade. A...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2004.06.020
更新日期：2004-11-15 00:00:00
abstract：:4-Bromo-2,5-dimethoxyphenethylamine (2C-B) is a psychoactive designer drug of abuse that is sold under the street names "Venus", "Bromo", "Erox", "XTC" or "Nexus". Concern has been raised because only little is known about its toxicity and metabolism in humans. In the present study we incubated 2C-B with human, monkey...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2004.07.004
更新日期：2005-01-05 00:00:00
abstract：:Toxicology and carcinogenesis studies of 2 structurally-related p-phenylenediamines, HC Blue No. 1, and HC Blue No. 2 were conducted by administering each chemical in feed for 103 weeks to both sexes of Fischer 344/N rats and B6C3F1 (C57BL/6N x C3H/HEN) mice. Diets containing 0, 1500, or 3000 ppm HC Blue 1 were fed to...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(89)90130-3
更新日期：1989-06-01 00:00:00
abstract：:Daily oral administration of either 20, 40 or 60 mg/kg chlorphentermine for 7 days significantly increased liver and kidney DNA levels, which were not elevated further even after a 3 week treatment period. Although cessation of drug administration for 3 weeks resulted in a return of hepatic DNA levels to control value...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/0300-483x(78)90057-4
更新日期：1978-05-01 00:00:00
abstract：:We have reported that excessive nitric oxide (NO), like other reactive oxygen species (ROS), causes a decrease in cytochrome c oxidase (CCO) activity and ATP levels (mitochondrial damage) resulting in lens opacity. In addition, previous reports have shown that oxidative stress caused by ROS enhances amyloid β (Aβ) pro...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/j.tox.2017.02.014
更新日期：2017-04-15 00:00:00
abstract：:Conditions for the optimal expression of the human CYP1B1 hemoprotein in Escherichia coli have been investigated. CYP1B1 cDNA was prepared from a retinal cDNA template and used to generate cDNA fragments with modified 5'-sequences reported to allow enhanced expression in E. coli DH5alpha. Plasmids were constructed, us...
journal_title：Toxicology
pub_type： 杂志文章
doi：10.1016/s0300-483x(99)00209-7
更新日期：2000-04-03 00:00:00
