当前位置： SCI文献检索 > Journal of Global Antimicrobial Resistance期刊下所有文献 > Coexistence of three blaKPC-2 genes on an IncF/IncR plasmid in ST11 Klebsiella pneumoniae.

Coexistence of three blaKPC-2 genes on an IncF/IncR plasmid in ST11 Klebsiella pneumoniae.

Abstract：

OBJECTIVES:Here we report the finding of three copies of the blaKPC-2 gene on a plasmid in ST11 Klebsiella pneumoniae. METHODS:Carbapenem-resistant K. pneumoniae clinical strain WCHKP2 was subjected to whole-genome sequencing (WGS) using both a short-read Illumina HiSeq X10 platform and long-read MinION sequencer. Hybrid assembly was performed using Unicycler, and contigs were corrected using Pilon. Based on WGS, the sequence type (ST), capsular type, plasmid replicon type and plasmid multilocus sequence type were determined and virulence and antimicrobial resistance genes were identified. Mating was performed to identify a self-transmissible plasmid mediating carbapenem resistance. RESULTS:Strain WCHKP2 was resistant to imipenem [minimum inhibitory concentration (MIC)=64μg/mL] and meropenem (MIC=128μg/mL). Strain WCHKP2 had a 5477148-bp circular chromosome, two small ColRNAI-like plasmids (5596bp and 10060bp), and one large plasmid (177516bp, designated pKPC2_020002) containing an IncR and an IncFII replicon. Surprisingly, there were three copies of the blaKPC-2 carbapenemase gene on pKPC2_020002, which was not self-transmissible. Each of the blaKPC-2 genes was located in the same genetic context with insertion sequence ISKpn27 upstream and ISKpn6 downstream and bracketed by IS26. The three copies of the IS26-ISKpn27-blaKPC-2-ISKpn6-IS26 unit were present in tandem. CONCLUSION:Here we report the surprising co-existence of three copies of blaKPC-2 on an IncR/IncF plasmid due to the action of IS26. Multiple copies of IS26 are a key factor generating genetic plasticity and could mediate the multiplication of resistance genes.

journal_name

J Glob Antimicrob Resist

journal_title

Journal of global antimicrobial resistance

authors

Feng Y,Liu L,McNally A,Zong Z

doi

10.1016/j.jgar.2018.11.017

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

90-93

eissn

2213-7165

issn

2213-7173

pii

S2213-7165(18)30233-9

journal_volume

17

pub_type

杂志文章

相关文献

Journal of Global Antimicrobial Resistance文献大全
  • Resistance mechanisms and clinical characteristics of linezolid-resistant Enterococcus faecium isolates: A single-centre study in South Korea.

    abstract：OBJECTIVES:This study aimed to determine the prevalence of linezolid-resistant (LR) vancomycin-resistant enterococci and to investigate the mechanisms of linezolid resistance with clinical and microbiological characterisation. METHODS:All vancomycin-resistant Enterococcus faecium (VREF) isolated from blood and rectal ...

    journal_title：Journal of global antimicrobial resistance

    pub_type： 杂志文章

    doi：10.1016/j.jgar.2017.09.009

    authors： Cho SY,Kim HM,Chung DR,Kim SH,Huh HJ,Kang CI,Peck KR,Lee NY,Song JH

    更新日期：2018-03-01 00:00:00

  • IncC blaKPC-2-positive plasmid characterised from ST648 Escherichia coli.

    abstract：OBJECTIVES:This study describes the characterisation of type 2 IncC plasmids pC-Ec20-KPC and pC-Ec2-KPC, carrying theblaKPC-2 gene, from two multiresistant Escherichia coli recovered in University Hospital of Larissa (Greece) in 2018. METHODS:E. coli strains Ec-2Lar and Ec-20Lar were recovered from rectal swabs of two...

    journal_title：Journal of global antimicrobial resistance

    pub_type： 杂志文章

    doi：10.1016/j.jgar.2019.05.001

    authors： Papagiannitsis CC,Bitar I,Malli E,Tsilipounidaki K,Hrabak J,Petinaki E

    更新日期：2019-12-01 00:00:00

  • Infections by OXA-48-like-producing Klebsiella pneumoniae non-co-producing extended-spectrum beta-lactamase: Can they be successfully treated with cephalosporins?

    abstract：BACKGROUND:OXA-48 is an Ambler class D β-lactamase that hydrolyses penicillin and imipenem but has poor hydrolytic activity against cephalosporins. However, very few clinical experiences of treating extended-spectrum β-lactamase (ESBL)-negative OXA-48 producers with cephalosporins have been published. OBJECTIVES:The a...

    journal_title：Journal of global antimicrobial resistance

    pub_type： 杂志文章

    doi：10.1016/j.jgar.2019.02.016

    authors： Escolà-Vergé L,Larrosa N,Los-Arcos I,Viñado B,González-López JJ,Pigrau C,Almirante B,Len O

    更新日期：2019-12-01 00:00:00

  • Genetic diversity and in vitro activity of ceftazidime/avibactam and aztreonam/avibactam against imipenem-resistant Enterobacteriaceae isolates in Southwest China: A single-centre study.

    abstract：OBJECTIVES:The aim of this study was to investigate the molecular mechanisms of imipenem resistance in Enterobacteriaceae and to assess the antimicrobial activities of ceftazidime/avibactam (CAZ/AVI) and aztreonam/avibactam (ATM/AVI) against imipenem-resistant clinical isolates in a tertiary hospital in China. METHODS...

    journal_title：Journal of global antimicrobial resistance

    pub_type： 杂志文章

    doi：10.1016/j.jgar.2020.04.023

    authors： Wei J,Zou C,Wang D,Huang A,Niu S

    更新日期：2020-09-01 00:00:00

  • High prevalence of blaCMY AmpC beta-lactamase in ESBL co-producing Escherichia coli and Klebsiella spp. clinical isolates in the northeast of Iran.

    abstract：OBJECTIVE:The production of β-lactamase enzymes such as AmpC β-lactamases and extended-spectrum β-lactamases (ESBLs) is among the main mechanisms for resistance to expanded-spectrum cephalosporins. The present study was conducted to investigate the prevalence and molecular epidemiology of plasmid-mediated AmpC beta (β)...

    journal_title：Journal of global antimicrobial resistance

    pub_type： 杂志文章

    doi：10.1016/j.jgar.2020.03.011

    authors： Rizi KS,Mosavat A,Youssefi M,Jamehdar SA,Ghazvini K,Safdari H,Amini Y,Farsiani H

    更新日期：2020-09-01 00:00:00

  • Insertion sequences disrupting mgrB in carbapenem-resistant Klebsiella pneumoniae strains in Brazil.

    abstract：OBJECTIVES:This study aimed to characterise insertional mutations disturbing themgrB gene in carbapenem-resistant Klebsiella pneumoniae (CRKp). METHODS:A total of 118 clinical CRKp isolates were surveyed for polymyxin resistance and insertion sequence (IS) elements disruptingmgrB. RESULTS:Of the 118 isolates, 78 (66....

    journal_title：Journal of global antimicrobial resistance

    pub_type： 杂志文章

    doi：10.1016/j.jgar.2020.11.003

    authors： Silva DMD,Faria-Junior C,Nery DR,Oliveira PM,Silva LOR,Alves EG,Lima GRCEC,Pereira AL

    更新日期：2020-11-24 00:00:00

  • Genomic analysis of two bacterial strains co-isolated from a urinary tract infection: NDM-1-producing Enterobacter cloacae accompanied by extended-spectrum β-lactamase-producing Escherichia coli.

    abstract：OBJECTIVES:Escherichia coli and Enterobacter cloacae are two major pathogens causing urinary tract infection (UTI). Here we characterised the genome of an NDM-1-producing E. cloacae strain and an extended-spectrum β-lactamase (ESBL)-producing E. coli strain that were co-isolated from a UTI. METHODS:The genomes of E. c...

    journal_title：Journal of global antimicrobial resistance

    pub_type： 杂志文章

    doi：10.1016/j.jgar.2019.04.007

    authors： Xu J,He F

    更新日期：2019-06-01 00:00:00

  • Antimicrobial susceptibility in hospitals in Hong Kong: The current status 2009-2011.

    abstract：:Hospitals in Hong Kong, like many hospitals in the world, are constantly challenged by the increasing rate of non-susceptible and multidrug-resistant organisms (MDROs). Accurate and timely surveillance is essential for effective control. The Hospital Authority of Hong Kong has developed a comprehensive antimicrobial s...

    journal_title：Journal of global antimicrobial resistance

    pub_type： 杂志文章,评审

    doi：10.1016/j.jgar.2014.05.008

    authors： Lai CK,Chuang WM,Kong MY,Siu HK,Tsang DN

    更新日期：2014-12-01 00:00:00

  • Urinary tract infection in Uruguayan children: Aetiology, antimicrobial resistance and uropathogenic Escherichia coli virulotyping.

    abstract：:Uropathogenic Escherichia coli (UPEC) is the most frequent cause of urinary tract infection (UTI). Virulence factors (VFs) of UPEC in children are not well known. Circulating antibiotic resistance mechanisms in the community are increasing. In this study, the aetiological agents of UTI and antibiotic resistance mechan...

    journal_title：Journal of global antimicrobial resistance

    pub_type： 杂志文章

    doi：10.1016/j.jgar.2014.08.003

    authors： Robino L,García-Fulgueiras V,Araujo L,Algorta G,Pírez MC,Vignoli R

    更新日期：2014-12-01 00:00:00

  • Interaction of carbapenems and β-lactamase inhibitors towards CTX-M-15 and CTX-M-15G238C mutant.

    abstract：OBJECTIVES:The aim of this study was to evaluate the role of residue 238 in CTX-M-15 and CTX-M-15G238C mutant with respect to carbapenems and various β-lactamase inhibitors. METHODS:A CTX-M-15G238C laboratory mutant was generated by site-directed mutagenesis from CTX-M-15 enzyme by replacing glycine 238 with cysteine....

    journal_title：Journal of global antimicrobial resistance

    pub_type： 杂志文章

    doi：10.1016/j.jgar.2017.04.004

    authors： Sabatini A,Brisdelli F,Celenza G,Marcoccia F,Colapietro M,Tavío MM,Piccirilli A,Amicosante G,Perilli M

    更新日期：2017-09-01 00:00:00

  • Genetic analysis of a PER-2-producing Shewanella sp. strain harbouring a variety of mobile genetic elements and antibiotic resistance determinants.

    abstract：:The objective of this study was to investigate the molecular mechanisms explaining the multidrug-resistant (MDR) phenotype found in a novel clinical Shewanella sp. strain (Shew256) recovered from a diabetic patient. Whole-genome shotgun sequencing was performed using Illumina MiSeq-I and Nextera XT DNA library. De nov...

    journal_title：Journal of global antimicrobial resistance

    pub_type： 杂志文章

    doi：10.1016/j.jgar.2017.06.005

    authors： Almuzara M,Montaña S,Lazzaro T,Uong S,Parmeciano Di Noto G,Traglia G,Bakai R,Centrón D,Iriarte A,Quiroga C,Ramirez MS

    更新日期：2017-12-01 00:00:00

  • Does the use of antifungal agents in agriculture and food foster polyene resistance development? A reason for concern.

    abstract：:Environmental fungicides are used in agriculture to reduce fungal spoilage of crops to a minimum, and the polyene macrolide natamycin is used as a food preservative. The use of natamycin in yoghurt has recently been authorised in the USA and some other countries. However, resistance development is a serious risk assoc...

    journal_title：Journal of global antimicrobial resistance

    pub_type： 杂志文章,评审

    doi：10.1016/j.jgar.2017.10.024

    authors： Dalhoff A

    更新日期：2018-06-01 00:00:00

  • First report of the mcr-1 colistin resistance gene identified in two Escherichia coli isolates from clinical samples, Philippines, 2018.

    abstract：OBJECTIVES:The first report of a plasmid-borne colistin resistance gene (mcr-1) detected in an Escherichia coli isolate from China heralded the emergence of pandrug-resistant bacteria. Since then, the mcr-1 gene has been detected worldwide, but to date it has not been reported in the Philippines. METHODS:In this study...

    journal_title：Journal of global antimicrobial resistance

    pub_type： 杂志文章

    doi：10.1016/j.jgar.2019.12.018

    authors： Velasco JMS,Valderama MTG,Margulieux KR,Diones PCS,Reyes AMB,Leonardia SG,Liao CP,Chua DA Jr,Navarro FCS,Ruekit S,Fernandez S,Macareo LR,Crawford JM,Swierczewski BE

    更新日期：2020-06-01 00:00:00

  • Characterisation of clinical canine meticillin-resistant and meticillin-susceptible Staphylococcus pseudintermedius in France.

    abstract：:Staphylococcus pseudintermedius is a frequent pathogen in dogs. The emergence of meticillin-resistant S. pseudintermedius (MRSP), which is concomitantly resistant to nearly all veterinary licensed antibiotics used for systemic treatment in dogs, is a major problem for veterinarians. In France, 16.9% (41/243) of the S....

    journal_title：Journal of global antimicrobial resistance

    pub_type： 杂志文章

    doi：10.1016/j.jgar.2014.02.002

    authors： Haenni M,de Moraes NA,Châtre P,Médaille C,Moodley A,Madec JY

    更新日期：2014-06-01 00:00:00

  • Pharmacokinetics of meropenem in burn patients with infections caused by Gram-negative bacteria: Are we getting close to the right treatment?

    abstract：OBJECTIVES:Infections caused by multidrug-resistant Gram-negative bacteria are associated with high mortality. A relevant concern is the efficacy of antibiotic therapy in burn patients in whom pathophysiological changes strongly influence pharmacokinetic (PK) parameters. This study aimed to describe the PK parameters o...

    journal_title：Journal of global antimicrobial resistance

    pub_type： 杂志文章

    doi：10.1016/j.jgar.2019.06.011

    authors： Corcione S,D'Avolio A,Loia RC,Pensa A,Segala FV,De Nicolò A,Fatiguso G,Romeo M,Di Perri G,Stella M,De Rosa FG

    更新日期：2020-03-01 00:00:00

  • Could Bordetella pertussis vaccine protect against coronavirus COVID-19?

    abstract：:According to the World Health Organization (WHO), as of today, there are 2.165.500 confirmed cases of the novel coronavirus disease (COVID-19) and 145.705 deaths in over 185 countries. Unfortunately, despite the tremendous efforts to develop a vaccine initiated by various leading health institutions all over the world...

    journal_title：Journal of global antimicrobial resistance

    pub_type： 杂志文章

    doi：10.1016/j.jgar.2020.07.005

    authors： Alkholy UM,Salama ME,Mahmoud H,Taher A 832-863-6551,Elsayes KM

    更新日期：2020-09-01 00:00:00

  • Antibiotic susceptibility and molecular epidemiology of Acinetobacter calcoaceticus-baumannii complex strains isolated from a referral hospital in northern Vietnam.

    abstract：:Acinetobacter calcoaceticus-baumannii complex is a common cause of hospital-acquired infections (HAIs) globally, remarkable for its high rate of antibiotic resistance, including to carbapenems. There are few data on the resistance of A. baumannii in Vietnam, which are essential for developing evidence-based treatment ...

    journal_title：Journal of global antimicrobial resistance

    pub_type： 杂志文章

    doi：10.1016/j.jgar.2014.05.003

    authors： Van TD,Dinh QD,Vu PD,Nguyen TV,Pham CV,Dao TT,Phung CD,Hoang HT,Tang NT,Do NT,Nguyen KV,Wertheim H

    更新日期：2014-12-01 00:00:00

  • Infectious diseases and antimicrobial prescribing: Online spaced education for junior doctors.

    abstract：BACKGROUND:Inappropriate antimicrobial prescribing may harm patients and drive antimicrobial resistance. Junior doctors' knowledge of infectious diseases and antimicrobial prescribing is inadequate. Online spaced case-based learning can improve knowledge. OBJECTIVE:To develop infectious diseases and antimicrobial pres...

    journal_title：Journal of global antimicrobial resistance

    pub_type： 杂志文章

    doi：10.1016/j.jgar.2020.02.008

    authors： Menon V,Chubaty A,Clezy K,Su Y,Post JJ,Janssen A,Shaw T,Konecny P

    更新日期：2020-09-01 00:00:00

  • Meropenem pharmacokinetics during extracorporeal membrane oxygenation and continuous haemodialysis: a case report.

    abstract：OBJECTIVES:Pharmacokinetic (PK) parameters can change significantly during extracorporeal membrane oxygenation (ECMO) and continuous haemodialysis. This case report describes the pharmacokinetics of a 3-h meropenem infusion in an infantile anuric patient on ECMO with continuous haemodialysis. CASE:A 19-month-old femal...

    journal_title：Journal of global antimicrobial resistance

    pub_type： 杂志文章

    doi：10.1016/j.jgar.2020.04.029

    authors： Saito J,Shoji K,Oho Y,Aoki S,Matsumoto S,Yoshida M,Nakamura H,Kaneko Y,Hayashi T,Yamatani A,Capparelli E,Miyairi I

    更新日期：2020-09-01 00:00:00

  • Global genotype distribution of human clinical isolates of New Delhi metallo-β-lactamase-producing Klebsiella pneumoniae; A systematic review.

    abstract：BACKGROUND AND AIM:The global rise of antimicrobial resistance among bacterial strains is a rapidly growing challenge and is becoming a major public health concern. This study documents the worldwide spread and genotype distribution of human clinical isolates of New Delhi metallo-β-lactamase-producing Klebsiella pneumo...

    journal_title：Journal of global antimicrobial resistance

    pub_type： 杂志文章,评审

    doi：10.1016/j.jgar.2020.10.016

    authors： Safavi M,Bostanshirin N,Hajikhani B,Yaslianifard S,van Belkum A,Goudarzi M,Hashemi A,Darban-Sarokhalil D,Dadashi M

    更新日期：2020-12-01 00:00:00

  • Methicillin-resistant Staphylococcus aureus nasal colonisation amongst healthcare workers in Kurdistan Region, Iraq.

    abstract：OBJECTIVES:The aim of this study was to determine the prevalence of nasal carriage of methicillin-resistant Staphylococcus aureus (MRSA) among healthcare workers (HCWs) compared with non-HCWs at Duhok city, Kurdistan Region, northern Iraq. METHODS:A total of 182 HCWs with different occupations and working in different...

    journal_title：Journal of global antimicrobial resistance

    pub_type： 杂志文章

    doi：10.1016/j.jgar.2017.01.010

    authors： Hussein NR,Assafi MS,Ijaz T

    更新日期：2017-06-01 00:00:00

  • Carbapenem-resistant Acinetobacter baumannii isolates carrying blaOXA genes with upstream ISAba1: First report of a novel OXA subclass from Iran.

    abstract：OBJECTIVES:Carbapenem-resistant Acinetobacter baumannii (CRAB) have emerged as a serious threat to public-health worldwide. This study aimed to determine the antimicrobial susceptibility of A. baumannii isolates in Iran and to investigate oxacillinase-encoding determinants and their association with insertion sequence ...

    journal_title：Journal of global antimicrobial resistance

    pub_type： 杂志文章

    doi：10.1016/j.jgar.2018.12.011

    authors： Yazdansetad S,Najari E,Ghaemi EA,Javid N,Hashemi A,Ardebili A

    更新日期：2019-09-01 00:00:00

  • Evaluation of vancomycin MIC creep in Staphylococcus aureus.

    abstract：OBJECTIVES:Vancomycin is the primary treatment for methicillin-resistant Staphylococcus aureus (MRSA). However, an increasing proportion of MRSA isolates with high minimum inhibitory concentrations (MICs) within the susceptible range (vancomycin 'MIC creep') is being observed. The aim of this study was to assess the va...

    journal_title：Journal of global antimicrobial resistance

    pub_type： 杂志文章

    doi：10.1016/j.jgar.2017.04.007

    authors： Diaz R,Ramalheira E,Afreixo V,Gago B

    更新日期：2017-09-01 00:00:00

  • Serotype distribution, antibiotic resistance patterns and molecular characteristics of serogroup 6 Streptococcus pneumoniae isolates collected from Chinese children before the introduction of PCV13.

    abstract：OBJECTIVES:Streptococcus pneumoniae is an important pathogen in infectious diseases worldwide, and serogroup 6 S. pneumoniae strains are very common in China. This study investigated the serotype distribution, antibiotic resistance patterns and molecular characteristics of 215 serogroup 6 S. pneumoniae isolates collect...

    journal_title：Journal of global antimicrobial resistance

    pub_type： 杂志文章

    doi：10.1016/j.jgar.2017.12.007

    authors： Shi W,Zhou K,Yuan L,Meng Q,Dong F,Gao W,Chen C,Wen D,Yao K

    更新日期：2018-09-01 00:00:00

  • Molecular mechanisms of clarithromycin resistance in Mycobacterium abscessus complex clinical isolates from Venezuela.

    abstract：:In this study, 26 clinical isolates of Mycobacterium abscessus complex strains were characterised using available identification algorithms for the three species (M. abscessus, M. massiliense and M. bolletii) and the genotypic characteristics of clarithromycin (CLR) resistance were determined. Strains were identified ...

    journal_title：Journal of global antimicrobial resistance

    pub_type： 杂志文章

    doi：10.1016/j.jgar.2015.05.007

    authors： Ramírez A,de Waard JH,Araque M

    更新日期：2015-09-01 00:00:00

  • In vitro bactericidal activity of 3-cinnamoyl-4-hydroxy-6-methyl-2-pyrone (CHP) against drug-susceptible, drug-resistant and drug-tolerant isolates of Mycobacterium tuberculosis.

    abstract：OBJECTIVES:Tuberculosis (TB) poses a serious global threat to humans. New bactericidal agents that can shorten treatment duration and target drug resistance still remain a top priority in the discovery of anti-TB drugs. The objective of this study was to investigate the bactericidal potential of 3-cinnamoyl-4-hydroxy-6...

    journal_title：Journal of global antimicrobial resistance

    pub_type： 杂志文章

    doi：10.1016/j.jgar.2019.11.018

    authors： Bhat ZS,Rather MA,Ul Lah H,Hussain A,Maqbool M,Yousuf SK,Jabeen Z,Wani MA,Ahmad Z

    更新日期：2020-09-01 00:00:00

  • Whole-genome sequencing reveals misidentification of a multidrug-resistant urine clinical isolate as Corynebacterium urealyticum.

    abstract：OBJECTIVES:Corynebacterium urealyticum is a non-diphtherial urease-producing clinically relevant corynebacterium associated with urinary tract infections. Most clinical C. urealyticum isolates are multidrug-resistant. Whole-genome sequencing (WGS) of C. urealyticum VH4248 isolated from a clinical urine sample at Hospit...

    journal_title：Journal of global antimicrobial resistance

    pub_type： 杂志文章

    doi：10.1016/j.jgar.2020.07.020

    authors： Rocha DJP,Azevedo V,Brenig B,Silva A,Blom J,Ramos RT,Aguiar ERG,Chapartegui-González I,Fernández-Martínez M,Martínez-Martínez L,Pacheco LGC,Navas J

    更新日期：2020-12-01 00:00:00

  • Clinical epidemiology of vancomycin-resistant Enterococcus gallinarum and Enterococcus casseliflavus bloodstream infections.

    abstract：:This study aimed to evaluate the clinical outcomes of vancomycin-resistant enterococcal bloodstream infections (VRE BSI) caused by Enterococcus gallinarum or Enterococcus casseliflavus. Variables associated with treatment failure were determined and treatment options were compared. This was a national retrospective st...

    journal_title：Journal of global antimicrobial resistance

    pub_type： 杂志文章

    doi：10.1016/j.jgar.2015.12.002

    authors： Britt NS,Potter EM

    更新日期：2016-06-01 00:00:00

  • Genomic features of a multidrug-resistant Enterobacter cloacae ST279 producing CTX-M-15 and AAC(6')-Ib-cr isolated from fatal infectious stomatitis in a crossed pit viper (Bothrops alternatus).

    abstract：OBJECTIVES:The widespread dissemination of extended-spectrum β-lactamase-producing Enterobacteriaceae has become a major issue in veterinary medicine. However, until now, there has been no report of bacteria with such a phenotype in infected snakes. The aim of this study was to report the first draft genome sequence of...

    journal_title：Journal of global antimicrobial resistance

    pub_type： 杂志文章

    doi：10.1016/j.jgar.2018.11.009

    authors： de Carvalho MPN,Moura Q,Fernandes MR,Sellera FP,Pagotto AH,Stuginski DR,Castro RA,Sant'Anna SS,Grego KF,Lincopan N

    更新日期：2018-12-01 00:00:00

  • Polymyxin monotherapy versus polymyxin-based combination therapy against carbapenem-resistant Klebsiella pneumoniae: A systematic review and meta-analysis.

    abstract：OBJECTIVES:This meta-analysis was performed to compare polymyxin monotherapy and polymyxin-based combination therapy for carbapenem-resistant Klebsiella pneumoniae (CR-KP) infections. METHODS:We conducted searches on MEDLINE, Embase and Cochrane Collaborative database for both observational studies and randomised cont...

    journal_title：Journal of global antimicrobial resistance

    pub_type： 杂志文章

    doi：10.1016/j.jgar.2020.08.024

    authors： Hou SY,Wu D,Feng XH

    更新日期：2020-12-01 00:00:00