Abstract：
OBJECTIVES:Although an association between uric acid (UA) levels and obstructive sleep apnea (OSA) has been reported, the effect of continuous positive airway pressure (CPAP) on this measure is yet unclear. We aimed to investigate the effect of CPAP therapy on serum UA levels in patients with OSA. METHODS:We conducted a multicenter, open-label, randomized controlled trial in 307 women diagnosed with moderate-to-severe OSA (apnea-hypopnea index [AHI]≥15) in 19 Spanish Sleep Units. Women were randomized to CPAP (n=151) or conservative treatment (n=156) for 12 weeks. Changes in serum UA measures were assessed on an intention-to-treat basis. Additional analyses were conducted in the subgroup of women with CPAP adherence ≥4h/night and those with UA levels ≥6mg/dl. RESULTS:Women had a mean (SD) age of 57.1 (10.1) years, median (first-third quartile) body mass index of 33.7 (29.0-38.5) mg/kg2 and AHI of 32.0 (22.6-48.5). The average serum UA measure was 5.11 (1.26) mg/dl, and 80 (26.1%) participants had UA≥6mg/dl. Compared with the control group, the CPAP group did not achieve any reduction in UA levels (non-adjusted intergroup difference -0.03mg/dl, 95%CI -0.20 to 0.13; p=0.702) after 12 weeks of follow-up. These results did not change when the analysis was restricted to women with CPAP adherence ≥4h/night, or the subgroup of women with hyperuricemia. CONCLUSIONS:Twelve weeks of CPAP therapy does not reduce UA levels compared to conservative treatment in women with moderate-to-severe OSA.
journal_name
Arch Bronconeumoljournal_title
Archivos de bronconeumologiaauthors
Campos-Rodriguez F,Reyes-Nuñez N,Queipo-Corona C,Sanchez-Armengol A,Jurado-Gamez B,Cordero-Guevara J,Troncoso MF,Abad-Fernandez A,Caballero-Rodriguez J,Martin-Romero M,Encabo-Motiño A,Sacristan-Bou L,Navarro-Esteva J,Somoza-Gondoi
10.1016/j.arbres.2018.09.012subject
Has Abstractpub_date
2019-04-01 00:00:00pages
201-207issue
4eissn
0300-2896issn
1579-2129pii
S0300-2896(18)30346-6journal_volume
55pub_type
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journal_title：Archivos de bronconeumologia
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