Abstract：
INTRODUCTION:The impact of pulmonary hypertension (PH) on exercise tolerance in chronic obstructive pulmonary disease (COPD) has not been fully elucidated. It is necessary to characterize pulmonary hemodynamics in patients with moderate to severe COPD in order to improve their management. The aim of the study was to determine whether in COPD the presence of PH is associated with reduced exercise tolerance in a cohort of stable COPD patients. METHODS:Cross-sectional analysis of 174 COPD patients clinically stable: 109 without PH and 65 with PH (COPD-PH). We assessed socio-demographic data, lung function, quality of life, dyspnea, cardiopulmonary exercise testing (CPET), constant workload endurance time (CWET), and six-minute walk test (6MWT). We elaborated a logistic regression model to explore the impact of PH on exercise capacity in COPD patients. RESULTS:COPD-PH patients showed lower exercise capacity both at maximal (CPET) (43(20) versus 68(27) Watts and 50(19)% versus 71(18)% predicted peak oxygen consumption (VO2peak), COPD-PH and COPD, respectively), and at submaximal tests (6MWT) (382(94) versus 486(95) m). In addition, the COPD-PH group had lower endurance time than the non-PH COPD group (265(113) s and 295(164) s, respectively). CONCLUSIONS:The presence of PH is an independent factor that impairs exercise capacity in COPD.
journal_name
Arch Bronconeumoljournal_title
Archivos de bronconeumologiaauthors
Blanco I,Valeiro B,Torres-Castro R,Barberán-García A,Torralba Y,Moisés J,Sebastián L,Osorio J,Rios J,Gimeno-Santos E,Roca J,Barberà JAdoi
10.1016/j.arbres.2019.10.015subject
Has Abstractpub_date
2020-08-01 00:00:00pages
499-505issue
8eissn
0300-2896issn
1579-2129pii
S0300-2896(19)30407-7journal_volume
56pub_type
杂志文章abstract：:Changes in cell immunity made manifest by decreases in blood levels of CD4 T cells is the main indicator of progressing HIV infection. The decrease in these lymphocytes, as well as in the CD4/CD8 index and increases in suppressant or cytotoxic CD8 cells can be detected in bronchoalveolar (BAL) lung samples. It is not ...
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