Abstract:
:The cancer stem cell (CSC) model encompasses an advantageous paradigm that in recent decades provides a better elucidation for many important biological aspects of cancer initiation, progression, metastasis, and, more important, development of multidrug resistance (MDR). Such several other hematological malignancies and solid tumors and the identification and isolation of ovarian cancer stem cells (OV-CSCs) show that ovarian cancer also follows this hierarchical model. Gaining a better insight into CSC-mediated resistance holds promise for improving current ovarian cancer therapies and prolonging the survival of recurrent ovarian cancer patients in the future. Therefore, in this review, we will discuss some important mechanisms by which CSCs can escape chemotherapy, and then review the recent and growing body of evidence that supports the contribution of CSCs to MDR in ovarian cancer.
journal_name
J Cell Physioljournal_title
Journal of cellular physiologyauthors
Mihanfar A,Aghazadeh Attari J,Mohebbi I,Majidinia M,Kaviani M,Yousefi M,Yousefi Bdoi
10.1002/jcp.26768subject
Has Abstractpub_date
2019-04-01 00:00:00pages
3238-3253issue
4eissn
0021-9541issn
1097-4652journal_volume
234pub_type
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