Size-dependent hyaluronate degradation by cultured cells.

abstract：:Our previous studies have demonstrated that platelet-targeted factor IX (FIX) gene therapy can introduce sustained platelet-FIX expression in hemophilia B (FIXnull ) mice. In this study, we aimed to enhance platelet-FIX expression in FIXnull mice with O6 -methylguanine-DNA-methyltransferase (MGMT)-mediated in vivo dru...

journal_title：Journal of cellular physiology

authors： Chen Y,Schroeder JA,Gao C,Li J,Hu J,Shi Q

更新日期：2021-01-01 00:00:00

abstract：:The vascular isoform of ATP-sensitive K(+) (KATP ) channels regulates blood flow to all organs. The KATP channel is strongly inhibited by reactive oxygen and carbonyl species produced in diabetic tissue inflammation. To address how such channel inhibition impacts vascular regulation as well as tissue viability, we per...

journal_title：Journal of cellular physiology

authors： Li SS,Cui N,Yang Y,Trower TC,Wei YM,Wu Y,Zhang S,Jin X,Jiang C

更新日期：2015-12-01 00:00:00

abstract：:A mouse mammary epithelial cell line, NMuMG, exhibits a low capacity to grow in semisolid medium as colonies and it is not tumorigenic in nude mice. In contrast, NMuMG cells which have been transformed by an activated c-Harvey ras proto-oncogene, NMuMG/rasH, or by the polyoma middle T-transforming gene, NMuMG/pyt, are...

journal_title：Journal of cellular physiology

authors： Salomon DS,Perroteau I,Kidwell WR,Tam J,Derynck R

更新日期：1987-03-01 00:00:00

abstract：:Suppressor of cytokine signaling (SOCS)-2 regulates normal postnatal growth and its deficiency in mice causes gigantism with increased bone length and proportional enlargement in skeletal muscles. Using C2C12 mesenchymal precursor cell line as a model, we investigated a possible role of SOCS-2 in the differentiation p...

journal_title：Journal of cellular physiology

authors： Ouyang X,Fujimoto M,Nakagawa R,Serada S,Tanaka T,Nomura S,Kawase I,Kishimoto T,Naka T

更新日期：2006-05-01 00:00:00

abstract：:The SV40 transformed murine macrophage cell line, BAC1, proliferates in response to the colony stimulating factor, CSF-1 (Schwarzbaum et al., J. Immunol., 132:1158, 1984). In order to obtain a cell line suitable for biochemical and genetic studies of CSF-1 signal transduction, clones of BAC1 were established. Clones r...

journal_title：Journal of cellular physiology

authors： Morgan C,Pollard JW,Stanley ER

更新日期：1987-03-01 00:00:00

abstract：:Heparan sulfate from the surface of a variety of mouse cells at different cell densities was examined by ion-exchange chromatography. The results of this analysis show that: (1) The heparan sulfate from new isolates of Swiss 3T3 cells transformed by SV40 virus (a DNA tumor virus) elutes from DEAE-cellulose at a lower ...

journal_title：Journal of cellular physiology

authors： Underhill CB,Keller JM

更新日期：1977-01-01 00:00:00

abstract：:New perspectives have been opened by advances in stem cell research for reproductive and regenerative medicine. Several different cell types can be differentiated from stem cells (SCs) under suitable in vitro and in vivo conditions. The differentiation of SCs into male germ cells has been reported by many groups. Due ...

journal_title：Journal of cellular physiology

authors： Mahabadi JA,Sabzalipoor H,Nikzad H,Seyedhosseini E,Enderami SE,Gheibi Hayat SM,Sahebkar A

更新日期：2019-08-01 00:00:00

abstract：:Calcium-activated nucleotidase 1 (CANT1, belongs to the apyrase family, is widely expressed in various organs. However, the biological function of CANT1 remains poorly explored. In this study, we aimed to investigate the expression profile and functions of CANT1 in clear cell renal cell carcinoma (ccRCC). Our data sho...

journal_title：Journal of cellular physiology

authors： Liu X,Yang Z,Luo X,Luo J,Fu W,Fang Z,Xia D,Li L,Xu J

更新日期：2019-12-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is mainly associated with hepatitis B virus (HBV) infection and characterized by metastasizing and infiltrating adjacent and distant tissues. Notably, microRNA-1271 (miR-1271) is a tumor suppressor in various cancers. Therefore, we evaluate the ability of miR-1271 to influence cell proli...

journal_title：Journal of cellular physiology

authors： Chen Y,Zhao ZX,Huang F,Yuan XW,Deng L,Tang D

更新日期：2019-04-01 00:00:00

abstract：:The protein tyrosine kinase pp125FAK (focal adhesion kinase, or FAK) is expressed by a variety of cell types and has been implicated in integrin-mediated signaling events. We explored the potential functions of FAK by expressing it de novo in a cell type lacking FAK. We showed previously that cultured human macrophage...

journal_title：Journal of cellular physiology

authors： De Nichilo MO,Katz BZ,O'Connell B,Yamada KM

更新日期：1999-02-01 00:00:00

abstract：:A temperature-sensitive mutant with a defect in glycoprotein synthesis and a cell cycle (G1)-specific arrest at the nonpermissive temperature (Tenner et al., J. Cell. Physiol., 90:145-160, 1977; Tenner and Scheffler, J. Cell. Physiol., 98:251-266, 1979) was investigated further after a human epidermal growth factor (E...

journal_title：Journal of cellular physiology

authors： Feige JJ,Scheffler IE

更新日期：1987-12-01 00:00:00

abstract：:Control of the terminal event in cellular differentiation is an important normal regulatory process, and the expression of defects in the control of this process has been implicated in the pathogenesis of cancer. To determine if tumor necrosis factor (TNF), which is an important biological response modifier, can inhib...

journal_title：Journal of cellular physiology

authors： Filipak M,Sparks RL,Tzen CY,Scott RE

更新日期：1988-11-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer death worldwide. Although diagnostic methods and targeted drugs have been rapidly developed in recent years, the underlying molecular mechanisms in the pathogenesis of lung cancer remain enigmatic. The N6-methyladenosine (m6 A) modification is the most common modification of ...

journal_title：Journal of cellular physiology

authors： Xu R,Pang G,Zhao Q,Yang L,Chen S,Jiang L,Shen Y,Shao W

更新日期：2020-11-01 00:00:00

abstract：:Human lymphocytes were equilibrated for 48 hours at 5-6 mM K+ ex over a range of temperatures between 0 and 37 degrees C, and at 5 degrees C over a range of external K+ levels between 0 and 32 mM. Cell K+ and Na+ contents are normal between 37 and 10 decrees. Below 10 degrees there is a critical thermal transition in ...

journal_title：Journal of cellular physiology

authors： Negendank W,Shaller C

更新日期：1980-04-01 00:00:00

abstract：:Studies on the receptor specificity and dynamics involved in fibroblast phagocytosis of latex beads revealed the following: 1) Ligands other than fibronectin such as concanavalin A (ConA) and serum spreading factor, when coated on latex beads, were found to promote phagocytosis of the beads. This indicates that fibrob...

journal_title：Journal of cellular physiology

authors： McAbee DD,Grinnell F

更新日期：1985-08-01 00:00:00

abstract：:We have previously reported that interferon-alpha (IFNalpha) induces apoptosis and EGF can antagonize this effect in human epidermoid cancer KB cells. Since apoptosis occurs together with cytoskeleton reorganization we have evaluated if IFNalpha and EGF could modulate cell remodeling in our experimental conditions. We...

journal_title：Journal of cellular physiology

authors： Boccellino M,Giuberti G,Quagliuolo L,Marra M,D'Alessandro AM,Fujita H,Giovane A,Abbruzzese A,Caraglia M

更新日期：2004-10-01 00:00:00

abstract：:The components of unidirectional K influx and efflux have been investigated in the 3T3 cell and the SV40 transformed 3T3 cell in expontntial and stationary growth phase. Over the cell densities used for transport experiments the 3T3 cell goes from exponential growth to density dependent inhibition of growth (4 X 10(4)...

journal_title：Journal of cellular physiology

authors： Spaggiare S,Wallach MJ,Tupper JT

更新日期：1976-11-01 00:00:00

abstract：:We examined the expression of the estrogen and epidermal growth factor (EGF) receptors in a drug-resistant subline of MCF-7 cells in order to study potential alterations in hormone dependence or in the growth factor pathway that could be related to the development of drug resistance in human breast cancer. The drug-re...

journal_title：Journal of cellular physiology

authors： Dickstein B,Valverius EM,Wosikowski K,Saceda M,Pearson JW,Martin MB,Bates SE

更新日期：1993-10-01 00:00:00

abstract：:Cell therapy is one of the important therapeutic approaches in the treatment of many diseases such as cancer, degenerative diseases, and cardiovascular diseases. Among various cell types, which could be used as cell therapies, stem cell therapy has emerged as powerful tools in the treatment of several diseases. Multip...

journal_title：Journal of cellular physiology

authors： Baniebrahimi G,Khanmohammadi R,Mir F

更新日期：2019-03-01 00:00:00

abstract：:The role of calmodulin (CaM) in modulating calcium (Ca) uptake by sarcoplasmic reticulum (SR) of vascular smooth muscle was studied in saponin skinned strips of rat caudal artery. Exogenous CaM concentrations ranging from 0.3-1.8 microM did not statistically change the steady state MgATP-dependent Ca content, the MgAT...

journal_title：Journal of cellular physiology

authors： Stout MA,Silver PJ

更新日期：1992-10-01 00:00:00

abstract：:Bioinformatics is an interdisciplinary field that blends computer science and biostatistics with biological and biomedical sciences such as biochemistry, cell biology, developmental biology, genetics, genomics, and physiology. An important goal of bioinformatics is to facilitate the management, analysis, and interpret...

journal_title：Journal of cellular physiology

authors： Moore JH

更新日期：2007-11-01 00:00:00

abstract：:Acute lung injury (ALI) is a severe acute inflammatory reaction of the lungs caused by a variety of factors, which can lead to a high mortality rate. MicroRNAs are a novel therapeutic molecule that play a vital role in many diseases. However, its mechanism of action in lipopolysaccharide (LPS)-induced mouse ALI is not...

journal_title：Journal of cellular physiology

authors： Guo S,Chen Y,Liu J,Yang J,Yang C,Zhang T,Jiang K,Wu Z,Shaukat A,Deng G

更新日期：2019-12-01 00:00:00

abstract：:Optical tweezers were used to scan individual Chronic Myelogenous Leukemia cells to determine if the cell death depends on the scanning conditions. Although increasing the scanning frequency or amplitude means greater force applied to the cells, their effects on cell death are not a simple increasing trend, as observe...

journal_title：Journal of cellular physiology

authors： Ng KS,Zhou ZL,Ngan AH

更新日期：2013-10-01 00:00:00

abstract：:Properties of the change from asparagine dependence (asn-) to independence (asn+) were investigated in the androgenetic haploid frog cell line ICR 2A. Two types of asn+ variants arose spontaneously during culture. Glutamine-dependent asparagine synthetase (AS) activity, found to be deficient in asn- cells, was repress...

journal_title：Journal of cellular physiology

authors： Hepfer CE,Little WA,Hengst JA,Freed JJ

更新日期：1989-04-01 00:00:00

abstract：:The transient nuclear localization of metallothionein during cell growth and differentiation may be related to the increased requirement of zinc for DNA synthesis, activation of metalloenzymes, and transcription factors. Treatment of 3T3-L1 fibroblasts with aphidicolin, an inhibitor of nuclear DNA synthesis, caused a ...

journal_title：Journal of cellular physiology

authors： Apostolova MD,Cherian MG

更新日期：2000-05-01 00:00:00

abstract：:We examined the interaction between OSU-03012 (also called AR-12) with phosphodiesterase 5 (PDE5) inhibitors to determine the role of the chaperone glucose-regulated protein (GRP78)/BiP/HSPA5 in the cellular response. Sildenafil (Viagra) interacted in a greater than additive fashion with OSU-03012 to kill stem-like GB...

journal_title：Journal of cellular physiology

authors： Booth L,Roberts JL,Tavallai M,Nourbakhsh A,Chuckalovcak J,Carter J,Poklepovic A,Dent P

更新日期：2015-08-01 00:00:00

abstract：:Numerous studies have reported that long noncoding RNA (lncRNA) dysregulation is involved in the progression of many malignant tumors, including glioma. The lncRNA ZNFX1 antisense RNA 1 (ZFAS1) plays an oncogenic role in various malignant tumors, such as gastric cancer and hepatocellular carcinoma. However, the underl...

journal_title：Journal of cellular physiology

authors： Li X,Luo Y,Liu L,Cui S,Chen W,Zeng A,Shi Y,Luo L

更新日期：2020-03-01 00:00:00

abstract：:This review addresses peptide regions of human tumor liberated protein (TLP) complexes with antigenic activity. The review also deals with antibodies reacting with such proteins, to be used for diagnostic and clinical purposes. We identified peptide sequences of the TLP 100 kDa protein. Lung cancer cells were found po...

journal_title：Journal of cellular physiology

authors： Tarro G

更新日期：2009-10-01 00:00:00

abstract：:Cancer cells in poorly vascularized solid tumors are constantly or intermittently exposed to stressful microenvironments, including glucose deprivation, hypoxia, and other forms of nutrient starvation. These tumor-specific conditions, especially glucose deprivation, activate a signaling pathway called the unfolded pro...

journal_title：Journal of cellular physiology

authors： Kim JY,Hwang JH,Cha MR,Yoon MY,Son ES,Tomida A,Ko B,Song SW,Shin-ya K,Hwang YI,Park HR

更新日期：2010-07-01 00:00:00

abstract：:Recent studies have suggested that interferons (IFNs) have an antifibrotic effect in the liver independent of their antiviral effect although its detailed mechanism remains largely unknown. Some microRNAs have been reported to regulate pathophysiological activities of hepatic stellate cells (HSCs). We performed analys...

journal_title：Journal of cellular physiology

authors： Sekiya Y,Ogawa T,Iizuka M,Yoshizato K,Ikeda K,Kawada N

更新日期：2011-10-01 00:00:00