Abstract:
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journal_name
Sci Repjournal_title
Scientific reportsauthors
Bebber DP,Butt Ndoi
10.1038/s41598-018-32998-8subject
Has Abstractpub_date
2018-10-01 00:00:00pages
14845issue
1issn
2045-2322pii
10.1038/s41598-018-32998-8journal_volume
8pub_type
已发布勘误abstract::Adipocyte differentiation and function relies on a network of transcription factors, which is disrupted in obesity-associated low grade, chronic inflammation leading to adipose tissue dysfunction. In this context, there is a need for a thorough understanding of the transcriptional regulatory network involved in adipos...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-017-14570-y
更新日期:2017-10-26 00:00:00
abstract::Synthetic biology enables infinite possibilities in biotechnology via employing genetic modules. However, not many researches have explored the potentials of synthetic biology in environmental bioprocesses. In this study, we introduced a genetic module harboring the codon-optimized tetracycline degrading gene, tetX.co...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21350-9
更新日期:2018-02-13 00:00:00
abstract::Leaf traces are important structures in higher plants that connect leaves and the stem vascular system. The anatomy and emission pattern of leaf traces are well studied in extant vascular plants, but remain poorly understood in fossil lineages. We quantitatively analysed the leaf traces in the late Permian conifer Nin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12405
更新日期:2015-07-22 00:00:00
abstract::Copper-based compounds are promising entities for target-specific next-generation anticancer and NSAIDS therapeutics. In lieu of this, benzimidazole scaffold plays an important role, because of their wide variety of potential functionalizations and coordination modes. Herein, we report three copper complexes 1-3 with ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41063-x
更新日期:2019-03-27 00:00:00
abstract::Inositol Requiring Enzyme-1 (IRE1) is the most conserved transducer of the Unfolded Protein Response (UPR), a surveillance mechanism that ensures homeostasis of the endoplasmic reticulum (ER) in eukaryotes. IRE1 activation orchestrates adaptive responses, including lipid anabolism, metabolic reprogramming, increases i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16662-1
更新日期:2017-11-28 00:00:00
abstract::Vitamin D may reduce mortality from prostate cancer (PC). We examined the associations of post-treatment plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D concentrations with PC mortality. Participants were PC cases from the New South Wales Prostate Cancer Care. All contactable and consenting participants, at 4.9...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62182-w
更新日期:2020-05-08 00:00:00
abstract::Epigenetic variation is implicated in a range of non-communicable diseases, including those of the eye. However, investigating the role of epigenetic variation in central tissues, such as eye or brain, remains problematic and peripheral tissues are often used as surrogates. In this study, matched human blood and eye t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46330
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abstract::The establishment of a healthy gastrointestinal milieu may not only offer an opportunity to reduce swine production costs but could also open the way for a lifetime of human health improvement. This study investigates the effects of feeding soluble fibre from flaxseed meal-containing diet (FM) and insoluble fibre from...
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pub_type: 杂志文章
doi:10.1038/s41598-018-24043-5
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abstract::Wave retarders having spatially varying optical axes orientations, called q-plates are extremely efficient devices for converting spin to orbital angular momentum of light and for the generation of optical vortices. Most often, these plates are designed for a specific wavelength and have a homogeneous constant retarda...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48163-8
更新日期:2019-08-15 00:00:00
abstract::The ability of radial glial progenitors (RGPs) to generate cortical neurons is determined by local extracellular factors and signaling pathways intrinsic to RGPs. Here we find that GPR157, an orphan G protein-coupled receptor, localizes to RGPs' primary cilia exposed to the cerebrospinal fluid (CSF). GPR157 couples wi...
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pub_type: 杂志文章
doi:10.1038/srep25180
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abstract::Turner syndrome (TS) is associated with decreased bone mineral density and increased fracture rate. However, the developmental trajectory of bone density or body composition in patients with TS is still unclear. The present study tested the hypothesis that different karyotypes and/or age contributes to abnormal body c...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/srep38026
更新日期:2016-11-30 00:00:00
abstract::The majority of colorectal cancer (CRC) arises from precursor lesions known as polyps. The molecular determinants that distinguish benign from malignant polyps remain unclear. To molecularly characterize polyps, we utilized Cancer Adjacent Polyp (CAP) and Cancer Free Polyp (CFP) patients. CAPs had tissues from the res...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21525-4
更新日期:2018-02-16 00:00:00
abstract::The global increase in Diabetes Mellitus (DM) has led to an increase in DM-Chronic Kidney Disease (DM-CKD). In this cross-sectional observational study we aimed to define phenotypes for patients with DM-CKD that in future may be used to individualise treatment We report 4 DM-CKD phenotypes in 220 patients recruited fr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18595-1
更新日期:2018-01-08 00:00:00
abstract::In the current study, we aimed to investigate whether NADPH oxidase, a major ROS-producing enzyme, was involved in the antioxidant effect of acupuncture on cognitive impairment after cerebral ischaemia. The cognitive function, infract size, neuron cell loss, level of superoxide anion and expression of NADPH oxidase su...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17981
更新日期:2015-12-10 00:00:00
abstract::New Delhi metallo-β-lactamase (NDM) had been reported to be the predominant carbapenemase among Escherichia coli in Taiwan. However, studies focusing on the clonal background and epidemiology of plasmids carrying NDM genes were limited. Between 2016 and 2018, all clinical E. coli and Klebsiella pneumoniae isolates tha...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-82166-8
更新日期:2021-01-28 00:00:00
abstract::The association of fasting glucose with the risk of death according to sex and age remains unclear, and insufficient information is available on sex- and age-specific glucose concentrations within ethnic groups. This study analyzed a sample of 12,455,361 Korean adults who participated in health examinations during 200...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08498-6
更新日期:2017-08-15 00:00:00
abstract::Plasmonically enhanced metal-insulator-metal (MIM) type structures are popular among perfect absorbers and photodetectors in which the field enhancement (for increased absorption) mechanism is directly coupled with collection (photocurrent) processes. In this work we propose a device structure that decouples absorptio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42349
更新日期:2017-02-09 00:00:00
abstract::Many amorphous materials show spatially heterogenous dynamics, as different regions of the same system relax at different rates. Such a signature, known as Dynamic Heterogeneity, has been crucial to understand the nature of the jamming transition in simple model systems and is currently considered very promising to ch...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43496
更新日期:2017-03-14 00:00:00
abstract::A novel flexible electret membrane, exhibiting persistent electrostatic effect, distinctive temperature stability and outstanding capability of resistance to harsh environment and fatigue, is demonstrated by experiment. Its excellent electret performance is correlated to the synergy of three factors, which are space c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07747-y
更新日期:2017-08-16 00:00:00
abstract::Spinal Muscular Atrophy (SMA) is caused by mutation or deletion of the survival motor neuron 1 (SMN1) gene. Decreased levels of, cell-ubiquitous, SMN protein is associated with a range of systemic pathologies reported in severe patients. Despite high levels of SMN protein in normal liver, there is no comprehensive stu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34635
更新日期:2016-10-04 00:00:00
abstract::We aim to evaluate the association of systolic and diastolic blood pressure (SBP and DBP) with estimated urinary sodium (Na) and potassium(K) excretions, and their gram-to-gram Na/K ratio across various salt-diet regions during 2005-2009 in China. A prospective cohort study was conducted to recruit 46,285 participants...
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pub_type: 杂志文章
doi:10.1038/s41598-018-25097-1
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abstract::Osteosarcoma pulmonary metastases are typically treated with resection and/or chemotherapy. We hypothesize that stereotactic radiosurgery (SRS) can be an alternative to surgery that can achieve high rates of local control with limited toxicity. From January 2005 to December 2013, 73 patients who developed pulmonary me...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14521-7
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abstract::Filamentous fungi naturally grow on solid surfaces, yet most genetic and biochemical analyses are still performed in liquid cultures. Here, we report a multiplexing platform using high-throughput photometric continuous reading that allows parallel quantification of hyphal growth and reporter gene expression directly o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03598-9
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abstract::Greenhouse gas (GHG) emissions from livestock grazing systems are contributing to global warming. To examine the influence of yak grazing systems on GHG fluxes and relationships between GHG fluxes and environmental factors, we measured carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O) fluxes over three key s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40857
更新日期:2017-01-20 00:00:00
abstract::Small-molecule inhibitors of non-canonical IκB kinases TANK-binding kinase 1 (TBK1) and IκB kinase ε (IKKε) have shown to stimulate β-cell regeneration in multiple species. Here we demonstrate that TBK1 is predominantly expressed in β-cells in mammalian islets. Proteomic and transcriptome analyses revealed that geneti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76600-6
更新日期:2020-11-09 00:00:00
abstract::Maonan nationality is a relatively conservative and isolated minority in China. Little is known about the association of the Slit-Robo Rho GTPase activating protein 2 gene (SRGAP2) single nucleotide polymorphisms (SNPs) and serum lipid levels in the Chinese populations. This study was performed to clarify the associat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10950-6
更新日期:2017-09-14 00:00:00
abstract::Hydrogels are being extensively used for three-dimensional immobilization and culture of cells in fundamental biological studies, biochemical processes, and clinical treatments. However, it is still a challenge to support viability and regulate phenotypic activities of cells in a structurally stable gel, because the g...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08948
更新日期:2015-03-10 00:00:00
abstract::The dependency property and self-recovery of failure nodes both have great effects on the robustness of networks during the cascading process. Existing investigations focused mainly on the failure mechanism of static dependency groups without considering the time-dependency of interdependent nodes and the recovery mec...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37749
更新日期:2016-11-28 00:00:00
abstract::To investigate the changes and clinical significance of brain structural abnormalities in patients with Meige syndrome and related depressive symptoms. We retrospectively analysed clinical data, imaging examinations, and Hamilton Depression Rating scale scores in 46 patients with Meige syndrome from January 2017 to Ja...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71479-9
更新日期:2020-09-03 00:00:00
abstract::Plant evolutionary history influences the taxonomic composition of the root-associated bacterial community, but whether it can also modulate its functioning is unknown. Here, we tested the hypothesis that crop diversification is a significant factor determining the ecology of the functional group of nitrogen-fixing ba...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21690
更新日期:2016-02-23 00:00:00