Abstract:
OBJECTIVES:Numerous previous publications on the detection of bacterial isolates harbouring the mcr-1 gene from animals and humans strongly suggest an underlying route of transmission of colistin resistance via the food chain. The aim of this study was to investigate the presence of colistin-resistant (Col-R) bacteria in Indian food samples and to identify the underlying mechanisms conferring colistin resistance. METHODS:Raw food material, including poultry meat, mutton meat, fish, fruit and vegetables, collected from food outlets in Chennai, India, were processed to identify Col-R bacteria using eosin methylene blue agar supplemented with colistin. Colistin minimum inhibitory concentrations (MICs) were determined by the broth microdilution method. PCR for the mcr-1 and mcr-3 genes was performed on Col-R Escherichia coli and Klebsiella pneumoniae isolates. Mutations in the mgrB gene were analysed in K. pneumoniae isolates. One representative mcr-1-positive E. coli was subjected to whole-genome sequencing. RESULTS:Of 110 food samples tested, 51 (46.4%) were positive for non-intrinsic Col-R Gram-negative bacteria. Three E. coli isolates were found to harbour mcr-1, whereas none were positive for mcr-3. Ten K. pneumoniae isolates had alterations in mgrB, with mutations in four and insertional inactivation in six. CONCLUSION:The presence of Col-R bacteria and the mcr-1 gene in raw food samples further complicates the antimicrobial resistance scenario in India. To the best of our knowledge, this is the first report in the global literature on mgrB mutation and its insertional inactivation conferring Col-R in K. pneumoniae from food samples.
journal_name
J Glob Antimicrob Resistjournal_title
Journal of global antimicrobial resistanceauthors
Ghafur A,Shankar C,GnanaSoundari P,Venkatesan M,Mani D,Thirunarayanan MA,Veeraraghavan Bdoi
10.1016/j.jgar.2018.09.005subject
Has Abstractpub_date
2019-03-01 00:00:00pages
48-52eissn
2213-7165issn
2213-7173pii
S2213-7165(18)30178-4journal_volume
16pub_type
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journal_title:Journal of global antimicrobial resistance
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journal_title:Journal of global antimicrobial resistance
pub_type: 杂志文章,评审
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journal_title:Journal of global antimicrobial resistance
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doi:10.1016/j.jgar.2017.07.016
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journal_title:Journal of global antimicrobial resistance
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journal_title:Journal of global antimicrobial resistance
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journal_title:Journal of global antimicrobial resistance
pub_type: 杂志文章
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journal_title:Journal of global antimicrobial resistance
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doi:10.1016/j.jgar.2019.01.006
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journal_title:Journal of global antimicrobial resistance
pub_type: 杂志文章
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journal_title:Journal of global antimicrobial resistance
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journal_title:Journal of global antimicrobial resistance
pub_type: 杂志文章
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journal_title:Journal of global antimicrobial resistance
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更新日期:2020-12-07 00:00:00
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journal_title:Journal of global antimicrobial resistance
pub_type: 杂志文章
doi:10.1016/j.jgar.2017.03.008
更新日期:2017-09-01 00:00:00
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journal_title:Journal of global antimicrobial resistance
pub_type: 杂志文章
doi:10.1016/j.jgar.2019.03.002
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journal_title:Journal of global antimicrobial resistance
pub_type: 杂志文章
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journal_title:Journal of global antimicrobial resistance
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journal_title:Journal of global antimicrobial resistance
pub_type: 杂志文章
doi:10.1016/j.jgar.2019.05.022
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journal_title:Journal of global antimicrobial resistance
pub_type: 杂志文章,评审
doi:10.1016/j.jgar.2017.03.013
更新日期:2017-09-01 00:00:00
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journal_title:Journal of global antimicrobial resistance
pub_type: 杂志文章
doi:10.1016/j.jgar.2020.07.005
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journal_title:Journal of global antimicrobial resistance
pub_type: 杂志文章
doi:10.1016/j.jgar.2017.01.010
更新日期:2017-06-01 00:00:00
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journal_title:Journal of global antimicrobial resistance
pub_type: 杂志文章
doi:10.1016/j.jgar.2019.01.022
更新日期:2019-09-01 00:00:00
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journal_title:Journal of global antimicrobial resistance
pub_type: 杂志文章
doi:10.1016/j.jgar.2020.07.027
更新日期:2020-12-01 00:00:00
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journal_title:Journal of global antimicrobial resistance
pub_type: 杂志文章
doi:10.1016/j.jgar.2019.08.002
更新日期:2020-03-01 00:00:00
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journal_title:Journal of global antimicrobial resistance
pub_type: 杂志文章
doi:10.1016/j.jgar.2017.05.018
更新日期:2017-09-01 00:00:00
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journal_title:Journal of global antimicrobial resistance
pub_type: 杂志文章,评审
doi:10.1016/j.jgar.2013.03.010
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVES:Infections caused by multidrug-resistant Gram-negative bacteria are associated with high mortality. A relevant concern is the efficacy of antibiotic therapy in burn patients in whom pathophysiological changes strongly influence pharmacokinetic (PK) parameters. This study aimed to describe the PK parameters o...
journal_title:Journal of global antimicrobial resistance
pub_type: 杂志文章
doi:10.1016/j.jgar.2019.06.011
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVES:This study examined the antimicrobial susceptibility and resistance mechanisms of Clostridium difficile recovered in Greek hospitals during 2012-2015. METHODS:C. difficile isolates (n=88) were collected from clinically-confirmed C. difficile infection from symptomatic patients in 10 Greek hospitals. Minimum...
journal_title:Journal of global antimicrobial resistance
pub_type: 杂志文章
doi:10.1016/j.jgar.2018.09.009
更新日期:2019-03-01 00:00:00