Abstract：
:Efficient hematopoietic reconstitution of wild type mice requires preconditioning. Established experimental protocols exist to transplant hematopoietic stem cells into lethally irradiated or chemically myeloablated adult mice or unirradiated immunodeficient mice. We sought to develop a protocol to reconstitute immuno-replete neonatal mice. We describe irradiation and injection procedures for two-day old mice that lead to efficient long-term reconstitution of primary and secondary lymphoid organs. We demonstrate that the frequencies of lymphoid and myeloid cells in primary and secondary lymphoid organs are indistinguishable from unirradiated uninjected sex- and age-matched control animals by 5 weeks post-reconstitution. Thus, this system will facilitate studies aimed at understanding the developmental and environmental mechanisms that contribute to conditions that have a window of susceptibility during the perinatal period.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Laky K,Dugan P,Frischmeyer-Guerrerio PAdoi
10.1038/s41598-018-30767-1subject
Has Abstractpub_date
2018-08-16 00:00:00pages
12254issue
1issn
2045-2322pii
10.1038/s41598-018-30767-1journal_volume
8pub_type
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