Abstract:
:Based on structure modification and a high-throughput Jurkat-Lat cell screening model, we found that GIBH-LRA002, ethyl-2-amino-3-cyano-9-methyl-4-(trifluoromethyl)-4,9-dihydropyrano[2,3-b]indole-4-carboxylate, effectively reactivated the latent proviruses in a Jurkat-Lat cell line and primary CD4+ T cells from both chronic SIV-infected rhesus macaques and HIV-1 patients but without inducing systemic activation, making this compound attractive for potentially treating HIV-1 infection.
journal_name
Medchemcommjournal_title
MedChemCommauthors
Yang Q,Ding Y,Feng F,Pan E,Fan X,Ma X,Chen L,Zhao J,Sun Cdoi
10.1039/c7md00327gsubject
Has Abstractpub_date
2017-07-25 00:00:00pages
1806-1809issue
9eissn
2040-2503issn
2040-2511pii
c7md00327gjournal_volume
8pub_type
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