Abstract:
:The synthesis, biological evaluation and molecular modeling of a series of pyrrole compounds related to 3,5-dibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid that evaluates and optimizes C-4 substituents are reported. The key factor for microtubule depolymerization activity appears to be the presence of an appropriately positioned acceptor for Cys241β in the otherwise hydrophobic subpocket A.
journal_name
Medchemcommjournal_title
MedChemCommauthors
Da C,Telang N,Hall K,Kluball E,Barelli P,Finzel K,Jia X,Gupton JT,Mooberry SL,Kellogg GEdoi
10.1039/C2MD20320Ksubject
Has Abstractpub_date
2013-01-01 00:00:00pages
417-421issue
2eissn
2040-2503issn
2040-2511journal_volume
4pub_type
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