Abstract:
:The phenol of 1-(3-(1H-imidazol-1-yl)propyl)-3-(4-hydroxy-3-methoxyphenyl)thiourea was selectively carbon-11 labelled to generate [11C]PBD150 in 7.3% yield from [11C]methyl triflate (non-decay corrected; radiochemical purity ≥95%, specific activity = 5.7 Ci/µmol, n=5). Evaluation of [11C]PBD150 by small animal PET imaging (mouse and rat) determined it does not permeate the blood brain barrier, indicating previously described therapeutic effect in transgenic mice was likely not the result of inhibiting central nervous system glutaminyl cyclase.
journal_name
Medchemcommjournal_title
MedChemCommauthors
Brooks AF,Jackson IM,Shao X,Kropog GW,Sherman P,Quesada CA,Scott PJdoi
10.1039/C5MD00148Jsubject
Has Abstractpub_date
2015-06-01 00:00:00pages
1065-1068issue
6eissn
2040-2503issn
2040-2511journal_volume
6pub_type
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