Abstract:
:The potential for carbon monoxide-releasing molecules (CO-RMs) as antimicrobials represents an exciting prospective in the fight against antibiotic resistance. Trypto-CORM, a tryptophan-containing manganese(i) carbonyl, is toxic against E. coli following photo-activation. Here, we demonstrate that Trypto-CORM is toxic against Neisseria gonorrhoeae in the absence of photoactivation. Trypto-CORM toxicity was reversed by the high CO affinity globin leg-haemoglobin (Leg-Hb), indicating that the toxicity is due to CO release. Release of CO from Trypto-CORM in the dark was also detected with Leg-Hb (but not myoglobin) in vitro. N. gonorrhoeae is more sensitive to CO-based toxicity than other model bacterial pathogens, and may serve as a viable candidate for antimicrobial therapy using CO-RMs.
journal_name
Medchemcommjournal_title
MedChemCommauthors
Ward JS,Morgan R,Lynam JM,Fairlamb IJS,Moir JWBdoi
10.1039/c6md00603esubject
Has Abstractpub_date
2016-12-06 00:00:00pages
346-352issue
2eissn
2040-2503issn
2040-2511pii
c6md00603ejournal_volume
8pub_type
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