Abstract:
:Intrinsic and acquired resistance to conventional and targeted therapeutics is a fundamental reason for treatment failure in many cancer patients. Targeted approaches to overcome chemoresistance as well as resistance to targeted approaches require in depth understanding of the underlying molecular mechanisms. The anti-cancer activity of a drug can be limited by a broad variety of molecular events at different levels of drug action in a cell-autonomous and non-cell-autonomous manner. This review summarizes recent insights into the adaptive mechanisms used by tumours to resist therapy including cellular phenotypic plasticity, dynamic alterations of the tumour microenvironment, activation of redundant signal transduction pathways, modulation of drug target expression levels, and exploitation of pro-survival responses.
journal_name
Medchemcommjournal_title
MedChemCommauthors
Ferreira BI,Lie MK,Engelsen AST,Machado S,Link W,Lorens JBdoi
10.1039/c6md00394jsubject
Has Abstractpub_date
2016-10-21 00:00:00pages
53-66issue
1eissn
2040-2503issn
2040-2511pii
c6md00394jjournal_volume
8pub_type
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