Abstract:
:Potent, selective, and cell active small molecule kinase inhibitors are useful tools to help unravel the complexities of kinase signaling. As the biological functions of individual kinases become better understood, they can become targets of drug discovery efforts. The small molecules used to shed light on function can also then serve as chemical starting points in these drug discovery efforts. The Nek family of kinases has received very little attention, as judged by number of citations in PubMed, yet they appear to play many key roles and have been implicated in disease. Here we present our work to identify high quality chemical starting points that have emerged due to the increased incidence of broad kinome screening. We anticipate that this analysis will allow the community to progress towards the generation of chemical probes and eventually drugs that target members of the Nek family.
journal_name
Medchemcommjournal_title
MedChemCommauthors
Wells CI,Kapadia NR,Couñago RM,Drewry DHdoi
10.1039/c7md00510esubject
Has Abstractpub_date
2017-12-08 00:00:00pages
44-66issue
1eissn
2040-2503issn
2040-2511pii
c7md00510ejournal_volume
9pub_type
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