Abstract:
:A series of 4-thiazolidinone derivatives were synthesized and evaluated as novel human dihydroorotate dehydrogenase (hDHODH) inhibitors. Compounds 26 and 31 displayed IC50 values of 1.75 and 1.12 μM, respectively. The structure-activity relationship was summarized. Further binding mode analysis revealed that compound 31 could form a hydrogen bond with Tyr38 and a water-mediated hydrogen bond with Ala55, which may be necessary for maintaining the bioactivities of the compounds in this series. Further structural optimization of the para- or meta-position of the phenyl group at R will lead to the identification of more potent hDHODH inhibitors.
journal_name
Medchemcommjournal_title
MedChemCommauthors
Zeng F,Qi T,Li C,Li T,Li H,Li S,Zhu L,Xu Xdoi
10.1039/c7md00081bsubject
Has Abstractpub_date
2017-04-26 00:00:00pages
1297-1302issue
6eissn
2040-2503issn
2040-2511pii
c7md00081bjournal_volume
8pub_type
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