Abstract:
:The benzisoxazole analogs represent one of the privileged structures in medicinal chemistry and there has been an increasing number of studies on benzisoxazole-containing compounds. The unique benzisoxazole scaffold also exhibits an impressive potential as antimicrobial, anticancer, anti-inflammatory, anti-glycation agents and so on. This review examines the state of the art in medicinal chemistry as it relates to the comprehensive and general summary of the different benzisoxazole analogs, their use as starting building blocks of multifarious architectures on scales sufficient to drive human drug trials. The number of reports describing benzisoxazole-containing highly active compounds leads to the expectation that this scaffold will further emerge as a potential candidate in the field of drug discovery.
journal_name
Medchemcommjournal_title
MedChemCommauthors
Rakesh KP,Shantharam CS,Sridhara MB,Manukumar HM,Qin HLdoi
10.1039/c7md00449dsubject
Has Abstractpub_date
2017-10-31 00:00:00pages
2023-2039issue
11eissn
2040-2503issn
2040-2511pii
c7md00449djournal_volume
8pub_type
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