Abstract:
:Based on the scaffold of astemizole, three novel turn-on fluorescent probes (N1-N3) for human ether-a-go-go-related gene (hERG) potassium channel were developed herein. These probes have reasonable fluorescence properties, acceptable cell toxicity, and potent inhibitory activity, all of which contribute to cell imaging at the nanomolar level. Overall, these probes have the potential for setting up a screening system for hERG channels.
journal_name
Medchemcommjournal_title
MedChemCommauthors
Zhang X,Liu T,Wang B,Gao Y,Liu P,Li M,Du Ldoi
10.1039/c8md00562asubject
Has Abstractpub_date
2019-02-26 00:00:00pages
513-516issue
4eissn
2040-2503issn
2040-2511pii
c8md00562ajournal_volume
10pub_type
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