Abstract:
:A novel and simplified synthetic scaffold based on pladienolide was designed using a consensus pharmacophore hypothesis. An initial target was synthesized and evaluated to examine the role of the 3-hydroxy group and the methyl groups present at positions 10, 16, 20, 22 in 1, on biological activity. We report the first totally synthetic analog of this macrolide that shows biological activity. Our novel synthetic strategy enables the rapid synthesis of other new analogs of pladienolide in order to develop selective anticancer lead compounds.
journal_name
Medchemcommjournal_title
MedChemCommauthors
Gundluru MK,Pourpak A,Cui X,Morris SW,Webb TRdoi
10.1039/C1MD00040Csubject
Has Abstractpub_date
2011-01-01 00:00:00pages
904-908issue
9eissn
2040-2503issn
2040-2511journal_volume
2pub_type
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