Abstract:
:Tetrahydroisoquinoline (THIQ) is a key structural component in many biologically active molecules including natural products and synthetic pharmaceuticals. Here, we report on the use of transition-metal mediated [2 + 2 + 2] cyclotrimerisation of alkynes to generate tricyclic THIQs with potential to selectively inhibit AKR1C3.
journal_name
Medchemcommjournal_title
MedChemCommauthors
Santos ARN,Sheldrake HM,Ibrahim AIM,Danta CC,Bonanni D,Daga M,Oliaro-Bosso S,Boschi D,Lolli ML,Pors Kdoi
10.1039/c9md00201dsubject
Has Abstractpub_date
2019-06-27 00:00:00pages
1476-1480issue
8eissn
2040-2503issn
2040-2511pii
c9md00201djournal_volume
10pub_type
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