Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity.

Abstract:

:Tetrahydroisoquinoline (THIQ) is a key structural component in many biologically active molecules including natural products and synthetic pharmaceuticals. Here, we report on the use of transition-metal mediated [2 + 2 + 2] cyclotrimerisation of alkynes to generate tricyclic THIQs with potential to selectively inhibit AKR1C3.

journal_name

Medchemcomm

journal_title

MedChemComm

authors

Santos ARN,Sheldrake HM,Ibrahim AIM,Danta CC,Bonanni D,Daga M,Oliaro-Bosso S,Boschi D,Lolli ML,Pors K

doi

10.1039/c9md00201d

subject

Has Abstract

pub_date

2019-06-27 00:00:00

pages

1476-1480

issue

8

eissn

2040-2503

issn

2040-2511

pii

c9md00201d

journal_volume

10

pub_type

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