Abstract:
:The high storage capacities and excellent biocompatibilities of zinc(ii) metal-organic frameworks (Zn-MOFs) have made them outstanding candidates as drug delivery carriers. Recent studies on the pH-responsive processes based on carrier-drug interactions have proven them to be the most efficient and effective way to control the release profiles of drugs. To satisfy the ever-growing demand in cancer therapy, great efforts are being devoted to the development of methods to precisely control drug release and achieve targeted use of an active substance at the right time and place. In this review article, we discuss the diverse stimuli based on Zn-MOFs carriers that have been achieved upon external activation from single pH-stimulus-responsive or/and multiple pH-stimuli-responsive viewpoints. Also, the perspectives and future challenges in this type of carrier system are discussed.
journal_name
Medchemcommjournal_title
MedChemCommauthors
Liu W,Pan Y,Xiao W,Xu H,Liu D,Ren F,Peng X,Liu Jdoi
10.1039/c9md00400asubject
Has Abstractpub_date
2019-10-17 00:00:00pages
2038-2051issue
12eissn
2040-2503issn
2040-2511pii
c9md00400ajournal_volume
10pub_type
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