Abstract:
:A series of cyclic peptides were designed and prepared to investigate the physicochemical properties that affect oral bioavailabilty of this chemotype in rats. In particular, the ionization state of the peptide was examined by the incorporation of naturally occurring amino acid residues that are charged in differing regions of the gut. In addition, data was generated in a variety of in vitro assays and the usefulness of this data in predicting the subsequent oral bioavailability observed in the rat is discussed.
journal_name
Medchemcommjournal_title
MedChemCommauthors
Rand AC,Leung SS,Eng H,Rotter CJ,Sharma R,Kalgutkar AS,Zhang Y,Varma MV,Farley KA,Khunte B,Limberakis C,Price DA,Liras S,Mathiowetz AM,Jacobson MP,Lokey RSdoi
10.1039/C2MD20203Dsubject
Has Abstractpub_date
2012-10-01 00:00:00pages
1282-1289issue
10eissn
2040-2503issn
2040-2511journal_volume
3pub_type
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