A novel tumor-based epithelial-to-mesenchymal transition score that associates with prognosis and metastasis in patients with Stage II/III colorectal cancer.

abstract：:Three human ovarian cancer xenografts of different origin and grown s.c. in nude mice as well-established tumors were studied for their sensitivity to cisplatin (CDDP), cyclophosphamide (CTX), 131I-labelled anti-episialin monoclonal antibody (MAb) 139H2, or external-beam radiotherapy. The maximum tolerated dose of CDD...

journal_title：International journal of cancer

authors： Molthoff CF,Pinedo HM,Schlüper HM,Rutgers DH,Boven E

更新日期：1992-04-22 00:00:00

abstract：:To elucidate the mechanisms responsible for the development of anti-estrogen resistance, we have cloned and established 3 stable ICI-182,780-resistant sub-lines, MCF-7/182R-1, MCF-7/182R-6 and MCF-7/182R-7 from the estrogen-receptor(ER)-positive and estrogen-responsive human breast-cancer MCF-7 cell line by long-term ...

journal_title：International journal of cancer

authors： Larsen SS,Madsen MW,Jensen BL,Lykkesfeldt AE

更新日期：1997-09-17 00:00:00

abstract：:Abnormal expression of homeobox genes may lead to the development of leukemias, lymphomas, and solid tumors. Expression of homeobox genes in mammary glands, however, has not been studied actively until recently. We have examined the expression of POU homeobox genes in human breast cancer cell lines and human breast ti...

journal_title：International journal of cancer

authors： Jin T,Branch DR,Zhang X,Qi S,Youngson B,Goss PE

更新日期：1999-03-31 00:00:00

abstract：:Rabbits were immunized with extracts of primary or grafted intestinal adeno-carcinomas induced by carcinogenic drugs in inbred rats. After absorption with normal tissue extracts, the antisera were able to recognize three tumor-associated antigens. Two of them were glycoproteins, present in cancer cells but also, in tr...

journal_title：International journal of cancer

authors： Martin F,Martin MS,Bordes M,Knobel S

更新日期：1975-01-15 00:00:00

abstract：:T cell responses against malignant cells play a major role in maintaining remission and prolonging overall survival in patients after allogeneic stem cell transplantation and donor lymphocyte infusion (DLI) due to graft-versus-leukemia effect. For better characterization of the T cell responses, we assessed frequency ...

journal_title：International journal of cancer

authors： Hofmann S,Schmitt M,Götz M,Döhner H,Wiesneth M,Bunjes D,Greiner J

更新日期：2019-03-01 00:00:00

abstract：:Markers of exposure to polycyclic aromatic hydrocarbons (urinary 1-hydroxypyrene-glucuronide) and aromatic amines (4-aminobiphenyl-hemoglobin adducts), as well as urinary mutagenicity, were measured in 47 healthy smokers and 50 nonsmokers. DNA adducts were determined by P32-postlabeling in the exfoliated bladder cells...

journal_title：International journal of cancer

authors： Vineis P,Talaska G,Malaveille C,Bartsch H,Martone T,Sithisarankul P,Strickland P

更新日期：1996-01-26 00:00:00

abstract：:Tumorigenic clonal lines derived from soft agar colonies induced by DMBA-transformed feline embryo cells were isolated and characterized. The morphologically altered clonal cells formed large aggregates, growing in this aggregate form when suspended in liquid growth medium above an agar base and forming colonies in so...

journal_title：International journal of cancer

authors： Rhim JS,Koh KS,Chen A,Essex M

更新日期：1981-07-15 00:00:00

abstract：:The deleted in liver cancer 1 (DLC1) tumor suppressor is an important RhoGTP activating protein (RhoGAP) that plays a crucial role in many types of human cancers. Small GTPases regulate normal cellular processes but aberrant expression and activation of GTPases contribute to tumorigenesis. RhoGAP suppresses Rho activi...

journal_title：International journal of cancer

authors： Ko FC,Ping Yam JW

更新日期：2014-07-15 00:00:00

abstract：:The insulin-like growth factor I (IGF-I) signaling pathway has been shown to play an important role in several aspects of cancer biology, including metastasis. The aim of this study was to define the contribution of serum (endocrine) and local (tumour microenvironment) IGF-I on osteosarcoma tumour growth and metastasi...

journal_title：International journal of cancer

authors： Hong SH,Briggs J,Newman R,Hoffman K,Mendoza A,LeRoith D,Helman L,Yakar S,Khanna C

更新日期：2009-05-01 00:00:00

abstract：:Subtype-specific incidence patterns in populations at high risk of lymphoma offer insight into lymphomagenesis. The incidence profiles for the 2 most common non-Hodgkin lymphoma subtypes were compared for 2 immunodeficient populations, adults receiving a kidney transplant 1982-2003 (n = 7,730) or diagnosed with human ...

journal_title：International journal of cancer

authors： Vajdic CM,van Leeuwen MT,Turner JJ,McDonald AM,Webster AC,McDonald SP,Chapman JR,Kaldor JM,Grulich AE

更新日期：2010-12-01 00:00:00

abstract：:Melanoma is a highly malignant and increasingly common neoplasm. Because metastatic melanoma remains incurable, new treatment approaches are needed. Immunoliposomes have been previously shown to enhance the selective localization of immunoliposome-entrapped drugs to solid tumors with improvements in the therapeutic in...

journal_title：International journal of cancer

authors： Pagnan G,Montaldo PG,Pastorino F,Raffaghello L,Kirchmeier M,Allen TM,Ponzoni M

更新日期：1999-04-12 00:00:00

abstract：:Gab2, a docking-type signaling protein with demonstrated oncogenic potential, is overexpressed in breast cancer, but its prognostic significance and role in disease evolution remain unclear. Immunohistochemical detection of Gab2 in a large cohort of primary human breast cancers of known outcome revealed that while Gab...

journal_title：International journal of cancer

authors： Fleuren ED,O'Toole S,Millar EK,McNeil C,Lopez-Knowles E,Boulghourjian A,Croucher DR,Schramek D,Brummer T,Penninger JM,Sutherland RL,Daly RJ

更新日期：2010-09-01 00:00:00

abstract：:We evaluated cell survival, DNA double strand breaks (dsbs), and DNA synthesis following camptothecin (CPT) alone or concurrent CPT and X-radiation treatments in exponential-phase cultures of a radioresistant human melanoma cell line. Cell survival was measured by a clonogenic assay. DNA dsbs were measured by pulsed-f...

journal_title：International journal of cancer

authors： Ng CE,Mazaheri K,Payant C,Raaphorst GP

更新日期：2001-10-20 00:00:00

abstract：:Because of the absence of data on smoking history for patients in cancer registries, large population-based studies have been unable to directly assess the role of smoking in the risk of multiple primary cancers. In a random sample of 618 adults diagnosed with invasive cancer in 2002 and reported to the population-bas...

journal_title：International journal of cancer

authors： Polednak AP

更新日期：2006-07-01 00:00:00

abstract：:A wide variety of primary and metastatic human neoplasms express somatostatin receptors (SS-Rs). We evaluated the SS-R status of malignant lymphomas that had been surgically removed from 31 patients by use of in vitro SS-R autoradiography with the SS analog 125I-[Tyr3]-octreotide as radioligand. Of 11 low-grade-malign...

journal_title：International journal of cancer

authors： Reubi JC,Waser B,van Hagen M,Lamberts SW,Krenning EP,Gebbers JO,Laissue JA

更新日期：1992-04-01 00:00:00

abstract：:The relationship between breast cancer-associated fatty acid synthase (FAS; oncogenic antigen-519) and chemotherapy-induced cell damage has not been studied. We examined the ability of C75, a synthetic slow-binding inhibitor of FAS activity, to modulate the cytotoxic activity of the microtubule-interfering agent Taxol...

journal_title：International journal of cancer

authors： Menendez JA,Vellon L,Colomer R,Lupu R

更新日期：2005-05-20 00:00:00

abstract：:IL-21 is a member of the IL-2 cytokine family, produced by CD4+ T cells. We previously showed that immunotherapy (IT) with IL-21-transduced neuroblastoma cells (Neuro2a/IL-21) cured 33% of syngeneic mice bearing systemic NB. Here, we studied whether the removal of Treg cells could potentiate the therapeutic efficacy o...

journal_title：International journal of cancer

authors： Croce M,Corrias MV,Orengo AM,Brizzolara A,Carlini B,Borghi M,Rigo V,Pistoia V,Ferrini S

更新日期：2010-09-01 00:00:00

abstract：:Current literature on cancer epidemiology typically discusses etiology of cancer by cancer type. Risks of different cancer types are, however, correlated at population level and may provide etiological clues. We showed previously an unexpected very high positive correlation between breast cancer (BC) and young-adult H...

journal_title：International journal of cancer

authors： Savu A,Potter J,Li S,Yasui Y

更新日期：2008-09-01 00:00:00

abstract：:Studies in Shanghai and in north-east China indicate that cigarette smoking is a major contributor to the high rates of lung cancer in those areas, but doubts persist regarding the influence of cigarette use on lung cancer rates in other areas of China. In addition, the risk of lung cancer associated with other method...

journal_title：International journal of cancer

authors： Lubin JH,Li JY,Xuan XZ,Cai SK,Luo QS,Yang LF,Wang JZ,Yang L,Blot WJ

更新日期：1992-05-28 00:00:00

abstract：:It is generally assumed that inflammation influences carcinogenesis. We previously reported that dextran sodium sulfate (DSS) strongly enhances colon carcinogenesis in the Apc(Min/+) mice and the over-expression of inducible nitric oxide synthase (iNOS) contributes to this enhancement. In the current study, we investi...

journal_title：International journal of cancer

authors： Kohno H,Takahashi M,Yasui Y,Suzuki R,Miyamoto S,Kamanaka Y,Naka M,Maruyama T,Wakabayashi K,Tanaka T

更新日期：2007-08-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) receptors constitute a family of transmembrane proteins that bind TGF-beta ligands. In this study we assessed the growth responsiveness to TGF-beta 1 in pancreatic cancer cell lines and characterized the levels of expression of TGF-beta receptors in these cell lines and in hu...

journal_title：International journal of cancer

authors： Baldwin RL,Friess H,Yokoyama M,Lopez ME,Kobrin MS,Büchler MW,Korc M

更新日期：1996-07-17 00:00:00

abstract：:APC10.1 is a new intestinal cell line derived from ApcMin/+ mice that retains both the heterozygous Apc genotype and a nonactivated Wnt signaling pathway and displays an early neoplastic phenotype. Although tumorigenic both in immunodepressed and in immunocompetent syngeneic mice, it requires a high cell dose and a lo...

journal_title：International journal of cancer

authors： De Giovanni C,Landuzzi L,Nicoletti G,Astolfi A,Croci S,Micaroni M,Nanni P,Lollini PL

更新日期：2004-03-20 00:00:00

abstract：:Monoclonal antibody (MAb) B72.3 has been previously shown, by in vitro assays, to have a high degree of specificity for carcinomas of the colon, ovary and breast versus normal adult tissues. B72.3 IgG was labelled with 131I and injected i.v. into 20 patients with known or suspected colorectal cancer. All patients subs...

journal_title：International journal of cancer

authors： Esteban JM,Colcher D,Sugarbaker P,Carrasquillo JA,Bryant G,Thor A,Reynolds JC,Larson SM,Schlom J

更新日期：1987-01-15 00:00:00

abstract：:Homeobox-containing genes are a network of genes encoding DNA-binding proteins highly conserved throughout evolution. They are involved in the control of normal development as well as in the regulation of gene expression in adult differentiating systems, including hematopoiesis. Aberrant expression of homeobox-contain...

journal_title：International journal of cancer

authors： Celetti A,Barba P,Cillo C,Rotoli B,Boncinelli E,Magli MC

更新日期：1993-01-21 00:00:00

abstract：:The aim of this study was to identify pathways that have a significant impact during renal carcinogenesis. Sixty-seven paired samples of both noncancerous renal cortex tissue and cancerous tissue from patients with clear cell renal cell carcinomas (RCCs) were subjected to whole-exome, methylome and transcriptome analy...

journal_title：International journal of cancer

authors： Arai E,Sakamoto H,Ichikawa H,Totsuka H,Chiku S,Gotoh M,Mori T,Nakatani T,Ohnami S,Nakagawa T,Fujimoto H,Wang L,Aburatani H,Yoshida T,Kanai Y

更新日期：2014-09-15 00:00:00

abstract：:We examined pp60c-src protein kinase activity in human gastric carcinoma cell lines and gastric carcinoma tissues as well as normal mucosa. pp60c-src kinase activity was detected in all 5 carcinoma cell lines at various levels. Of 16 gastric carcinoma tissues, 8 showed higher pp60c-src kinase activity in tumor tissues...

journal_title：International journal of cancer

authors： Takekura N,Yasui W,Yoshida K,Tsujino T,Nakayama H,Kameda T,Yokozaki H,Nishimura Y,Ito H,Tahara E

更新日期：1990-05-15 00:00:00

abstract：:Aristolochic acid (AA), a naturally occurring nephrotoxin and carcinogen, has been associated with the development of urothelial cancer in humans. Understanding which human enzymes are involved in AA activation and/or detoxication is important in the assessment of an individual's susceptibility to this plant carcinoge...

journal_title：International journal of cancer

authors： Stiborová M,Frei E,Hodek P,Wiessler M,Schmeiser HH

更新日期：2005-01-10 00:00:00

abstract：:HER2 is an erbB/HER type 1 tyrosine kinase receptor that is frequently over-expressed in malignant epithelial tumours. Herceptin, a humanised mouse monoclonal antibody to HER2, is proven therapeutically in the management of metastatic breast cancer, significantly prolonging survival when combined with cytotoxic chemot...

journal_title：International journal of cancer

authors： Cox G,Vyberg M,Melgaard B,Askaa J,Oster A,O'Byrne KJ

更新日期：2001-05-15 00:00:00

abstract：:Regulatory T cells (Treg) mediate amelioration of disease and immune homeostasis by inhibiting immune activation and maintaining peripheral immune tolerance. The suppressive mechanisms and clinical significance of Treg have not been completely elucidated in patients with acute myeloid leukemia (AML). Here, we demonstr...

journal_title：International journal of cancer

authors： Shenghui Z,Yixiang H,Jianbo W,Kang Y,Laixi B,Yan Z,Xi X

更新日期：2011-09-15 00:00:00

abstract：:Natural cell-mediated immunity against autologous tumor cells, autologous endometrial epithelium, and allogeneic epidermoid carcinoma cell line HeLa was tested in 8 patients with endometrial carcinoma and one patient with endometrial stromal sarcoma. The average cytotoxicity of unstimulated peripheral blood lymphocyte...

journal_title：International journal of cancer

authors： Timonen T,Lehtovirta P,Saksela E

更新日期：1987-10-15 00:00:00