Abstract:
:Superficial laminae of the spinal cord possess a considerable number of neurons with spontaneous activity as reported in vivo and in vitro preparations of several species. Such neurons may play a role in the development of the nociceptive system and/or in the spinal coding of somatosensory signals. We have used electrophysiological techniques in a horizontal spinal cord slice preparation from adult mice to investigate how this activity is generated and what are the main patterns of activity that can be found. The results show the existence of neurons that fire regularly and irregularly. Within each of these main types, it was possible to distinguish patterns of spontaneous activity formed by single action potentials and different types of bursts according to intra-burst firing frequency. Activity in neurons with irregular patterns was blocked by a mixture of antagonists of the main neurotransmitter receptors present in the cord. Approximately 82% of neurons with a regular firing pattern were insensitive to synaptic antagonists but their activity was inhibited by specific ion channel blockers. It is suggested that these neurons generate endogenous activity due to the functional expression of hyperpolarisation-activated and persistent sodium currents driving the activity of irregular neurons.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Lucas-Romero J,Rivera-Arconada I,Roza C,Lopez-Garcia JAdoi
10.1038/s41598-018-27993-ysubject
Has Abstractpub_date
2018-06-27 00:00:00pages
9735issue
1issn
2045-2322pii
10.1038/s41598-018-27993-yjournal_volume
8pub_type
杂志文章abstract::A fracture is the most dangerous complication of osteoporosis in patients because the associated disability and mortality rates are high. Osteoporosis impairs fracture healing and prognosis, but how intramembranous ossification (IO) or endochondral ossification (EO) during fracture healing are affected and whether the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22095-1
更新日期:2018-03-01 00:00:00
abstract::Here we present the first report of a carbon-γ-Fe₂O₃ nanoparticle composite of mesoporous carbon, bearing COOH- and phenolic OH- functional groups on its surface, a remarkable and magnetically separable adsorbent, for the radioactive material emitted by the Fukushima Daiichi nuclear power plant accident. Contaminated ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06053
更新日期:2014-08-13 00:00:00
abstract::Low hydrophilicity of graphene is one of the major obstacles for biomaterials application. To create some hydrophilic groups on graphene is addressed this issue. Herein, COOH+ ion implantation modified graphene (COOH+/graphene) and COOH functionalized graphene were designed by physical ion implantation and chemical me...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37112
更新日期:2016-11-15 00:00:00
abstract::The high theoretical capacity and low discharge potential of silicon have attracted much attention on Si-based anodes. Herein, hollow porous SiO2 nanocubes have been prepared via a two-step hard-template process and evaluated as electrode materials for lithium-ion batteries. The hollow porous SiO2 nanocubes exhibited ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01568
更新日期:2013-01-01 00:00:00
abstract::Hepatitis C virus (HCV) has long been observed to take advantage of the host mitochondria to support viral replication and assembly. The HCV core protein has been implicated to fragment host mitochondria. In this report, we have discovered that the non-structural protein 5A (NS5A) plays an instructive role in attachin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23464
更新日期:2016-03-24 00:00:00
abstract::Plants are key determinants of soil microbial community (SMC). Legumes and grasses are distinct groups in various ecosystems; however, how they differentially shape SMC structure and functioning has yet to be explored. Here, we investigate SMC in soils grown with stylo (legume) or bahiagrass (grass). Soil metagenomic ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10613-6
更新日期:2017-08-31 00:00:00
abstract::Potential distributions of endemic relic shrubs in western Ordos were poorly mapped, which hindered our implementation of proper conservation. Here we investigated the applicability of ecological niche modeling for endangered relic shrubs to detect areas of priority for biodiversity conservation and analyze difference...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26268
更新日期:2016-05-20 00:00:00
abstract::Hallmarks of Retinitis Pigmentosa (RP), a family of genetic diseases, are a typical rod-cone-degeneration with initial night blindness and loss of peripheral vision, followed by decreased daylight sight and progressive visual acuity loss up to legal blindness. Great heterogeneity in nature and function of mutated gene...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06045-x
更新日期:2017-07-18 00:00:00
abstract::microRNAs regulate the expression of over 60% of protein coding genes by targeting their mRNAs to AGO2-containing complexes in the cytoplasm and promoting their translational inhibition and/or degradation. There is little evidence so far for microRNA-mediated regulation of other classes of non-coding RNAs. Here we rep...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02535
更新日期:2013-01-01 00:00:00
abstract::Phaseonium is a three-level Λ quantum system, in which a coherent microwave and an optical control (pump) beams can be used to actively modulate the dielectric response. Here we propose a new metamaterial structure comprising of a periodic array of triangular phaseonium metamolecules arranged as a trefoil. We present ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21083
更新日期:2016-02-16 00:00:00
abstract::We analyze the quantum phase effects for point-like charges and electric (magnetic) dipoles under a natural assumption that the observed phase for a dipole represents the sum of corresponding phases for charges composing this dipole. This way we disclose two novel quantum phases for charged particles, which we named a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30423-8
更新日期:2018-08-09 00:00:00
abstract::Synchrotron radiation microtomography (SRμCT) is a nominally non-destructive 3D imaging technique which can visualise the internal structures of whole soft tissues. As a multi-stage technique, the cumulative benefits of optimising sample preparation, scanning parameters and signal processing can improve SRμCT imaging ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30520-8
更新日期:2018-08-13 00:00:00
abstract::Flavonoids, theanine and caffeine are the main secondary metabolites of the tea plant (Camellia sinensis), which account for the tea's unique flavor quality and health benefits. The biosynthesis pathways of these metabolites have been extensively studied at the transcriptional level, but the regulatory mechanisms are ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39286-z
更新日期:2019-02-25 00:00:00
abstract::We present two transmission-mode dielectric Fresnel-Zone Plate Lens (FZPL) antennas for use within the V-band spectrum. The proposed FZPs are realized via pure plastic material using two different additive manufacturing processes. The proposed FZP lenses are designed with half (λ/2) and quarter (λ/4) phase correction ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23179-8
更新日期:2018-03-28 00:00:00
abstract::People with ataxia-telangiectasia (A-T) display phenotypic variability with regard to progression of immunodeficiency, sino-pulmonary disease, and neurologic decline. To determine the association between differential gene expression, epigenetic state, and phenotypic variation among people with A-T, we performed transc...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-020-64514-2
更新日期:2020-05-04 00:00:00
abstract::Oligomers populated during the early amyloid aggregation process are more toxic than mature fibrils, but pinpointing the exact toxic species among highly dynamic and heterogeneous aggregation intermediates remains a major challenge. β-barrel oligomers, structurally-determined recently for a slow-aggregating peptide de...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28649-7
更新日期:2018-07-09 00:00:00
abstract::The considerable range of genetic variation in human populations may partly reflect distinctive processes of adaptation to variable environmental conditions. However, the adaptive genomic signatures remain to be completely elucidated. This research explores candidate loci under selection at the population level by cha...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22468
更新日期:2016-03-02 00:00:00
abstract::Antibiotic administration, while facilitating clearance of targeted infections, also perturbs commensal microbial communities. Previous studies have all focused on the effects of short term use of antibiotics. Here, we focus on the effects of long term use of antibiotic on gut microbiota and immunity. BALB/c mice rece...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43035
更新日期:2017-02-21 00:00:00
abstract::The removal of macroalgal biomass is critical to the health of coral reef ecosystems. Previous studies on relatively intact reefs with diverse and abundant fish communities have quantified rapid removal of macroalgae by herbivorous fishes, yet how these findings relate to degraded reef systems where fish diversity and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08873-3
更新日期:2017-08-21 00:00:00
abstract::Three-dimensionally (3D) porous morphology of nanostructures can effectively improve their electrocatalytic activity and durability for various electrochemical reactions owing to big surface area and interconnected structure. Cyanogel, a jelly-like inorganic polymer, can be used to synthesize various three-dimensional...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07619
更新日期:2015-01-05 00:00:00
abstract::Staphylococcus epidermidis is the predominant cause of recalcitrant biofilm-associated infections, which are often highly resistant to antibiotics. Thus, the use of physico-chemical agents for disinfection offers a more effective approach to the control of S. epidermidis biofilm infections. However, the underlying tol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41797-8
更新日期:2019-03-29 00:00:00
abstract::Inter-specific emotion recognition is especially adaptive when species spend a long time in close association, like dogs and humans. Here, we comprehensively studied the human ability to recognize facial expressions associated with dog emotions (hereafter, emotions). Participants were presented with pictures of dogs, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52938-4
更新日期:2019-11-11 00:00:00
abstract::Accurate characterization of the mechanical properties of brain tissue is essential for understanding the mechanisms of traumatic brain injuries and developing protective gears or facilities. However, how storage conditions might affect the mechanical properties of brain tissue remains unclear. The objective of this s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19687-2
更新日期:2018-01-19 00:00:00
abstract::Insecticides and other agrochemicals have become indispensable components of the agricultural system to ensure a notable increase in crop yield and food production. As a natural consequence, chemical residues result in significantly increased contamination of both terrestrial and aquatic ecosystems. The present study ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76638-6
更新日期:2020-11-11 00:00:00
abstract::Lentiviral vectors (LVs) are excellent tools to promote gene transfer and stable gene expression. Their potential has been already demonstrated in gene therapy clinical trials for the treatment of diverse disorders. For large scale LV production, a stable producer system is desirable since it allows scalable and cost-...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23593-y
更新日期:2018-03-27 00:00:00
abstract::The Casimir force exerted on a gold dipolar nanoparticle by a finite-thickness slab of the natural hyperbolic material namely, the ortorhombic crystalline modification of boron nitride, is investigated. The main contribution to the force originates from the TM-polarized waves, for frequencies at which the parallel and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73995-0
更新日期:2020-10-08 00:00:00
abstract::It has been an old unsolved puzzle to evolutionary theorists on which mechanisms would increase large-scale cooperation in human societies. Thus, how such mechanisms operate in a biological network is still not well understood. This study addresses these questions with empirical evidence from agent-based models design...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17481-0
更新日期:2017-12-11 00:00:00
abstract::Theory predicts that social interactions can induce an alignment of behavioral asymmetries between individuals (i.e., population-level lateralization), but evidence for this effect is mixed. To understand how interaction with other individuals affects behavioral asymmetries, we systematically manipulated the social en...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61410-7
更新日期:2020-03-11 00:00:00
abstract::The field of genome editing was founded on the establishment of methods, such as the clustered regularly interspaced short palindromic repeat (CRISPR) and CRISPR-associated protein (CRISPR/Cas) system, used to target DNA double-strand breaks (DSBs). However, the efficiency of genome editing also largely depends on the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58893-9
更新日期:2020-02-13 00:00:00
abstract::The innate and adaptive immune systems fail to control HCV infection in the majority of infected individuals. HCV is an ssRNA virus, which suggests a role for Toll-like receptors (TLRs) 7 and 8 in initiating the anti-viral response. Here we demonstrate that HCV genomic RNA harbours specific sequences that initiate an ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29447
更新日期:2016-07-07 00:00:00