当前位置： SCI文献检索 > FORENSIC SCIENCE INTERNATIONAL期刊下所有文献 > Association between cytochrome P450 2D6 polymorphisms and body fluid methamphetamine concentrations in Japanese forensic autopsy cases.

Association between cytochrome P450 2D6 polymorphisms and body fluid methamphetamine concentrations in Japanese forensic autopsy cases.

Abstract：

:Methamphetamine (MA) is an illicit stimulant that affects the central nervous system. Cytochrome P450 2D6 (CYP2D6) plays an important role in MA metabolism. Numerous allelic variants confer substantial variation in CYP2D6 activity among individuals. In the present study, we examined the frequencies of CYP2D6 alleles, including CYP2D6*1, *2, *4, *5, *10, *14A, *14B, *18, and *36, and multiplication, in 82 forensic autopsy cases of MA abusers and 567 autopsy cases in which MA was not detected (controls). Ultrarapid metabolizer (UM), extensive metabolizer (EM), intermediate metabolizer (IM), and poor metabolizer (PM) phenotypes were predicted from CYP2D6 genotypes. Of MA abusers, 64 subjects were predicted to be EM, 17 were IM, and 1 was UM. No MA abuser had the predicted PM phenotype. No significant differences in CYP2D6 phenotype frequencies were found between MA abusers and controls. MA and amphetamine (AMP) concentrations were measured in the right heart blood, left heart blood, peripheral external iliac blood, urine, pericardial fluid, and bone marrow of MA abusers. MA concentrations in urine and bone marrow were significantly higher in IM than in EM. AMP concentration was not associated with CYP2D6 phenotype in any body fluid. These results suggest that the MA concentration in body fluids is influenced by CYP2D6 phenotypes in the Japanese population.

journal_name

Forensic Sci Int

journal_title

Forensic science international

authors

Matsusue A,Ikeda T,Tani N,Waters B,Hara K,Kashiwagi M,Takayama M,Ikematsu N,Kubo SI,Ishikawa T

doi

10.1016/j.forsciint.2018.05.018

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

33-39

eissn

0379-0738

issn

1872-6283

pii

S0379-0738(18)30263-9

journal_volume

289

pub_type

杂志文章

相关文献

FORENSIC SCIENCE INTERNATIONAL文献大全
  • An autopsy case of an infant with Joubert syndrome who died unexpectedly and a review of the literature.

    abstract：:The present report describes the unexpected death of a 6-month-old female infant who had been clinically diagnosed with Joubert syndrome. This is a relatively rare congenital neurological disorder characterized by hypoplasia/aplasia of cerebellar vermis, which transmits information from the body to the cerebellum, and...

    journal_title：Forensic science international

    pub_type： 杂志文章,评审

    doi：10.1016/j.forsciint.2008.06.003

    authors： Ishikawa T,Zhu BL,Li DR,Zhao D,Michiue T,Maeda H

    更新日期：2008-08-06 00:00:00

  • Determination of cocaine and its metabolites in brain tissue using high-flow solid-phase extraction columns and high-performance liquid chromatography.

    abstract：:A new solid-phase extraction procedure for the determination of cocaine and some of its metabolites in brain tissue, using high-flow co-polymeric sorbents is reported as a substantial improvement on our recently reported procedure. The recovery of cocaine, norcocaine and cocaethylene was excellent as was the reproduci...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/0379-0738(92)90197-5

    authors： Moore C,Browne S,Tebbett I,Negrusz A

    更新日期：1992-03-01 00:00:00

  • The forensic analysis of office paper using carbon isotope ratio mass spectrometry--part 2: method development, validation and sample handling.

    abstract：:This paper describes the development and validation of a method for the analysis of office papers by measuring carbon isotopes using isotope ratio mass spectrometry (IRMS). The method development phase included testing protocols for storage, sample materials, set-up of the analytical run; and examining the effects of ...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2013.05.009

    authors： Jones K,Benson S,Roux C

    更新日期：2013-09-10 00:00:00

  • Visualization of the air ejected from the temporary cavity in brain and tissue simulants during gunshot wounding.

    abstract：:One hypothesis for the physical mechanism responsible for backspatter during cranial gunshot wounding is that air is ejected by the collapse of the temporary cavity formed around the bullet path. Using bovine and ovine heads and simulant materials, evidence of this ejection was sought by measuring the velocity of the ...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2014.11.005

    authors： Lazarjan MS,Geoghegan PH,Taylor MC,Jermy MC

    更新日期：2015-01-01 00:00:00

  • Rapid GC-MS confirmation of amphetamines in urine by extractive acylation.

    abstract：:Amphetamine and related derivatives are widely abused central- and psychostimulants. Detection of certain derivatives, such as methcathinone, by commonly available immunoassay screening techniques is insufficient. Multi-analyte confirmations for amphetamine type stimulants are therefore required, but traditional gas c...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2008.10.021

    authors： Marais AA,Laurens JB

    更新日期：2009-01-10 00:00:00

  • Search for fungi-specific metabolites of four model drugs in postmortem blood as potential indicators of postmortem fungal metabolism.

    abstract：:Fungi colonizing cadavers are capable of drug metabolism and may thus change the metabolite pattern or concentration of drugs in forensic postmortem samples. The purpose of this study was to check for the presence of such changes by searching fungi-specific metabolites of four model drugs (amitriptyline, metoprolol, m...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2016.03.006

    authors： Martínez-Ramírez JA,Strien J,Walther G,Peters FT

    更新日期：2016-05-01 00:00:00

  • A case of fatal coin battery ingestion in a 2-year-old child.

    abstract：:Foreign body aspiration is frequently encountered in young children, in the majority of cases it will not lead to an adverse outcome. However, in case of coin battery ingestion more serious adverse outcomes, including death, have been reported. We present a case with fatal outcome due to exsanguination, of a 2-year-ol...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2010.02.001

    authors： Soerdjbalie-Maikoe V,van Rijn RR

    更新日期：2010-05-20 00:00:00

  • Determination of glycyrrhetic acid after consumption of liquorice and application to a fatality.

    abstract：:Besides alcohol and drugs of abuse, several popular foods contain potentially toxic substances and cases of intoxication after consumption of these foods attract notice of forensic toxicology. This is also true for the case of a 34-year-old woman who was suspected to have suffered lethal acute intoxication from eating...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2009.12.018

    authors： Albermann ME,Musshoff F,Hagemeier L,Madea B

    更新日期：2010-04-15 00:00:00

  • Using whole exome sequencing and bioformatics in the molecular autopsy of a sudden unexplained death syndrome (SUDS) case.

    abstract：:Whole exome sequencing (WES) and bioinformatics analysis were used to investigate potential disease-causing gene mutations in a sudden unexplained death syndrome (SUDS) case after autopsy and pathology tests failed to suggest an obvious disease mechanism. Following whole exome sequencing, a 3-step bioinformatics filte...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2015.08.022

    authors： Wang C,Duan S,Lv G,Lai X,Chen R,Lin H,Qiu S,Tang J,Kuang W,Xu C

    更新日期：2015-12-01 00:00:00

  • Determination of synthesis route of 1-(3,4-methylenedioxyphenyl)-2-propanone (MDP-2-P) based on impurity profiles of MDMA.

    abstract：:In our study 1-(3,4-methylenedioxyphenyl)-2-propanone (MDP-2-P or PMK) was prepared by two different routes, i.e. by oxidizing isosafrole in an acid medium and by 1-(3,4-methylenedioxyphenyl)-2-nitropropene reduction. The final product-MDP-2-P was subjected to GC/MS analysis. The intermediates and reaction by-products...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2004.06.016

    authors： Swist M,Wilamowski J,Zuba D,Kochana J,Parczewski A

    更新日期：2005-05-10 00:00:00

  • Post mortem vitreous magnesium in adult population.

    abstract：BACKGROUND:The study of post mortem vitreous magnesium (Mg) is less common than sodium (Na), chloride (Cl) and potassium (K) in the forensic literature. There is no accepted normal range for post mortem vitreous Mg and the relationship between post mortem vitreous Mg levels and post mortem interval (PMI), other electro...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2017.12.038

    authors： Tse R,Garland J,Kesha K,Morrow P,Lam L,Elstub H,Cala AD,Palmiere C,Stables S

    更新日期：2018-03-01 00:00:00

  • Prediction of stature from hand measurements.

    abstract：:A sample of 166 normal adult males and females was taken from different colleges of Assiut representing those living in upper Egypt. Each subject has been studied for measurements of stature (S), hand length (HL) and hand breadth (HB). The data were statistically analysed in order to assess the relationship between st...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/0379-0738(90)90304-h

    authors： Abdel-Malek AK,Ahmed AM,el-Sharkawi SA,el-Hamid NA

    更新日期：1990-07-01 00:00:00

  • Scanning electron microscope observations of heat-treated human bone.

    abstract：:This report describes the heat-induced alterations in human bone tissue observed using scanning electron microscopy and microradiography. Femoral bone samples were taken from persons varying in age from 1 year to 97 years at the time of their death. The bone was heated at selected temperatures in the range 200-1600 de...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/0379-0738(95)01735-2

    authors： Holden JL,Phakey PP,Clement JG

    更新日期：1995-06-30 00:00:00

  • STR-genotyping from human medieval tooth and bone samples.

    abstract：:We extracted the DNA contained in samples of bones and teeth from 10 skeletons excavated from the Gravette site (400-1000 AD, south of France). Ancient DNA was analysed by autosomal short tandem repeats (STRs). The DNA present in these ancient remains appeared very degraded, but nevertheless, better conserved in tooth...

    journal_title：Forensic science international

    pub_type： 历史文章,杂志文章

    doi：10.1016/j.forsciint.2004.07.001

    authors： Ricaut FX,Keyser-Tracqui C,Crubézy E,Ludes B

    更新日期：2005-06-30 00:00:00

  • Identification of children and adults through federal and state dental identification systems: recognition of human bite marks.

    abstract：:Forensic pathologists are often involved in the identification of unknown bodies. It is imperative, therefore, that they become aware of a national computerized identification system (NCIC) administered by the FBI. There is also a state system in California which has resulted in the identification of 59 individuals. T...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/0379-0738(86)90013-7

    authors： Sperber N

    更新日期：1986-02-01 00:00:00

  • Shrunken head (tsantsa): a complete forensic analysis procedure.

    abstract：:Based on the analysis of shrunken heads referred to our forensic laboratory for anthropological expertise, and data from both anthropological and medical literature, we propose a complete forensic procedure for the analysis of such pieces. A list of 14 original morphological criteria has been developed, based on the g...

    journal_title：Forensic science international

    pub_type： 历史文章,杂志文章

    doi：10.1016/j.forsciint.2012.06.009

    authors： Charlier P,Huynh-Charlier I,Brun L,Hervé C,de la Grandmaison GL

    更新日期：2012-10-10 00:00:00

  • Musculoskeletal stress marker (MSM) differences in the modern American upper limb and pectoral girdle in relation to activity level and body mass index (BMI).

    abstract：:Obesity is a widespread condition affecting modern Americans. The prevalence of obesity has led to questions of how it can affect the skeleton, and if so can it be identified in unknown skeletal material. This study attempts to decipher the effects of activity level and body mass in modern Americans by employing muscu...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2011.03.014

    authors： Godde K,Taylor RW

    更新日期：2011-07-15 00:00:00

  • Positive identification by X-rays bone trabeculae comparison.

    abstract：:Positive (certain, absolute) identification of human remains needs a scientific comparison between ante mortem and post-mortem biologic features, as fingerprint, odontological, radiological or DNA comparisons. X-rays comparison has been extensively used, usually comparing some peculiarities such as outlines of the bon...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2014.09.019

    authors： Quatrehomme G,Biglia E,Padovani B,du Jardin P,Alunni V

    更新日期：2014-12-01 00:00:00

  • Utilizing AFIS searching tools to reduce errors in fingerprint casework.

    abstract：:Fifty-six (56) adjudicated, property crime cases involving fingerprint evidence were reviewed using a case-specific AFIS database tool. This tool allowed fingerprint experts to search latent prints in the cases against a database of friction ridge exemplars limited to only the individuals specific to that particular c...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2015.07.054

    authors： Langenburg G,Hall C,Rosemarie Q

    更新日期：2015-12-01 00:00:00

  • Injuries due to deliberate violence in areas of Denmark. I. The extent of violence.

    abstract：:As part of a transcultural investigation of violent behavior in Denmark and South America an analysis was made during a one year period of the incidents involving deliberate violence as registered at 3 Danish emergency wards, and at the Institute of Forensic Medicine in Copenhagen. In the three emergency wards a total...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/0379-0738(89)90146-1

    authors： Breiting VB,Aalund O,Albrektsen SB,Danielsen L,Helweg-Larsen K,Jacobsen J,Kjaerulff H,Staugaard H,Thomsen JL

    更新日期：1989-02-01 00:00:00

  • The effectiveness of strong afterglow phosphor powder in the detection of fingermarks.

    abstract：:There are numerous types of fluorescent fingermark powders or reagents used with the visualization of latent fingermarks deposited on multicolored substrate surfaces that can present a contrast problem if developed with regular fingermark powders. The developed fingermarks can show bright fluorescence upon exposure to...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2008.10.008

    authors： Liu L,Zhang Z,Zhang L,Zhai Y

    更新日期：2009-01-10 00:00:00

  • Levels of cocaine and its metabolites in washed hair of demonstrated cocaine users and workplace subjects.

    abstract：:In a study of subjects in drug rehabilitation programs, cocaine and cocaine metabolite levels were determined in the hair of 75 subjects who had produced cocaine-positive urine results. The hair was analyzed after being washed with the 3.75 h wash procedure developed by this laboratory. In addition, results of testing...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2004.04.033

    authors： Cairns T,Hill V,Schaffer M,Thistle W

    更新日期：2004-10-29 00:00:00

  • Worldwide population variation in pelvic sexual dimorphism: A validation and recalibration of the Klales et al. method.

    abstract：:Sex estimation is an integral aspect of biological anthropology. Correctly estimating sex is the first step to many subsequent analyses, such as estimating living stature or age-at-death. Klales et al. (2012) [6] provided a revised version of the Phenice (1969) [3] method that expanded the original three traits (ventr...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2017.05.001

    authors： Kenyhercz MW,Klales AR,Stull KE,McCormick KA,Cole SJ

    更新日期：2017-08-01 00:00:00

  • Comparative analysis of differences by gender in sudden infant death syndrome in Hungary and Japan.

    abstract：:We examined the sex ratio in sudden infant death syndrome (SIDS) cases in Hungary, in Tokyo and Japan between 1985 and 1996. From all the infant death cases in Hungary 395 (240 male, 155 female) were SIDS (odds ratio (OR)=1.179, with 95% confidence interval (CI)=0.961, 1.446), in Japan 4348 (2550 male, 1798 female) we...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/s0379-0738(00)00354-6

    authors： Töro K,Sawaguchi T,Sawaguchi A,Rózsa S,Sótonyi P

    更新日期：2001-04-15 00:00:00

  • Mortality statistics and autopsy: reliability of estimation of the mode of death in Copenhagen and a rural district of Sealand, Denmark.

    abstract：:During a one-year-period 1243 medicolegal deaths in the City of Copenhagen were autopsied after the mode of death was provisionally determined by an external medicolegal examination. In 35% of the cases an atuopsy was requested by the police. Without autopsy the mode of death would have been defined erroneously in 10....

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/0379-0738(79)90137-3

    authors： Asnaes S

    更新日期：1979-11-01 00:00:00

  • Transmesenteric hernia due to double-loop formation in the small intestine: a fatal case involving a toddler.

    abstract：:We report a unique case of transmesenteric hernia resulting in death, which went undiagnosed during a recent hospital visit. The victim was a 2.5-year-old girl who - with the exception of chronic constipation - had no medical history. One night she complained of abdominal pains and was taken to a pediatric hospital wh...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2011.07.048

    authors： Kakimoto Y,Abiru H,Kotani H,Ozeki M,Tsuruyama T,Tamaki K

    更新日期：2012-01-10 00:00:00

  • Results of a collaborative study of the EDNAP group regarding mitochondrial DNA heteroplasmy and segregation in hair shafts.

    abstract：:A collaborative exercise was carried out by the European DNA Profiling Group (EDNAP) in order to evaluate the distribution of mitochondrial DNA (mtDNA) heteroplasmy amongst the hairs of an individual who displays point heteroplasmy in blood and buccal cells. A second aim of the exercise was to study reproducibility of...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/S0379-0738(03)00181-6

    authors： Tully G,Barritt SM,Bender K,Brignon E,Capelli C,Dimo-Simonin N,Eichmann C,Ernst CM,Lambert C,Lareu MV,Ludes B,Mevag B,Parson W,Pfeiffer H,Salas A,Schneider PM,Staalstrom E

    更新日期：2004-02-10 00:00:00

  • Microscopical characterization of known postmortem root bands using light and scanning electron microscopy.

    abstract：:A postmortem root band (PMRB) is a distinct microscopic feature that is postulated to occur in hair remaining in the follicle during the postmortem interval [1] (Petraco et al., 1998). The scientific validity of this premise has been highlighted in two recent high-profile criminal cases involving PMRBs [2,3] (State of...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2016.07.009

    authors： Hietpas J,Buscaglia J,Richard AH,Shaw S,Castillo HS,Donfack J

    更新日期：2016-10-01 00:00:00

  • Sexual dimorphism of ossified costal cartilage. Radiograph scan study on Caucasian men and women (Czech population).

    abstract：:The aim of our study was to evaluate differences between males and females based on patterns of costal cartilage ossification and also with respect to ageing. We provided diagnosis of ossifications from two files of radiograms. The first group consisted of 1044 chest and abdominal radiograms of patients (537 men and 5...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/j.forsciint.2009.06.009

    authors： Rejtarová O,Hejna P,Rejtar P,Bukac J,Slízová D,Krs O

    更新日期：2009-10-30 00:00:00

  • The changing phenomenology of drug death over the years.

    abstract：:When inspecting the scene the circumstances under which a body is found and the findings on the body surface may give first clues to premortal drug abuse. Besides fresh and/or old injection marks tattoos, underweight and signs of physical neglect, especially after long-term abuse, are mentioned in literature. The inci...

    journal_title：Forensic science international

    pub_type： 杂志文章

    doi：10.1016/s0379-0738(01)00587-4

    authors： Bohnert M,Hafezi M,Pollak S

    更新日期：2001-12-27 00:00:00