Transcriptome Analysis of Two Rice Varieties Contrasting for Nitrogen Use Efficiency under Chronic N Starvation Reveals Differences in Chloroplast and Starch Metabolism-Related Genes.

abstract：:Telomeric repeats, coated by the shelterin complex, prevent inappropriate activation of the DNA damage response at the ends of linear chromosomes. Shelterin has evolved distinct solutions to protect telomeres from different aspects of the DNA damage response. These solutions include formation of t-loops, which can seq...

journal_title：Genes

authors： Doksani Y

更新日期：2019-04-24 00:00:00

abstract：:RPE65 isomerase, expressed in the retinal pigmented epithelium (RPE), is an enzymatic component of the retinoid cycle, converting all-trans retinyl ester into 11-cis retinol, and it is essential for vision, because it replenishes the photon capturing 11-cis retinal. To date, almost 200 loss-of-function mutations have ...

journal_title：Genes

authors： Kiang AS,Kenna PF,Humphries MM,Ozaki E,Koenekoop RK,Campbell M,Farrar GJ,Humphries P

更新日期：2020-11-27 00:00:00

abstract：:The development of the udder and the milk yield are closely related to the number and vitality of mammary epithelial cells. Many previous studies have proved that non-coding RNAs (ncRNAs) are widely involved in mammary gland development and the physiological activities of lactation. Our laboratory previous sequencing ...

journal_title：Genes

authors： Zhang M,Ma L,Liu Y,He Y,Li G,An X,Cao B

更新日期：2020-06-28 00:00:00

abstract：:Pseudomonas savastanoi pv. savastanoi is the causal agent of Olive knot disease, relying on the Type Three Secretion System (TTSS) for its pathogenicity. In this regard, nothing was known about the two other pathovars belonging to this species, pv. nerii and pv. fraxini, characterized by a different host range. Here w...

journal_title：Genes

authors： Tegli S,Gori A,Cerboneschi M,Cipriani MG,Sisto A

更新日期：2011-11-25 00:00:00

abstract：:Fusarium head blight (FHB), caused primarily by the fungus Fusarium graminearum, is one of the most damaging diseases of wheat, causing significant loss of yield and quality worldwide. Warm and wet conditions during flowering, a lack of resistant wheat varieties, and high inoculum pressure from corn stubble contribute...

journal_title：Genes

authors： Castro Aviles A,Alan Harrison S,Joseph Arceneaux K,Brown-Guidera G,Esten Mason R,Baisakh N

更新日期：2020-06-25 00:00:00

abstract：:Synthesis of chromosomal DNA is initiated from multiple origins of replication in higher eukaryotes; however, little is known about these origins' structures. We isolated the origin-derived nascent DNAs from a human repair-deficient cell line by blocking the replication forks near the origins using two different origi...

journal_title：Genes

authors： Eki T,Murakami Y,Hanaoka F

更新日期：2013-04-17 00:00:00

abstract：:The histone-like nucleoid structuring protein (H-NS) has played a key role in shaping the evolution of Shigella spp., and provides the backdrop to the regulatory cascade that controls virulence by silencing many genes found on the large virulence plasmid. H-NS and its paralogue StpA are present in all four Shigella sp...

journal_title：Genes

authors： Picker MA,Wing HJ

更新日期：2016-12-01 00:00:00

abstract：:Metabolic resistance to insecticides threatens malaria control. However, little is known about its fitness cost in field populations of malaria vectors, thus limiting the design of suitable resistance management strategies. Here, we assessed the association between the glutathione S-transferase GSTe2-mediated metaboli...

journal_title：Genes

authors： Tchouakui M,Riveron JM,Djonabaye D,Tchapga W,Irving H,Soh Takam P,Njiokou F,Wondji CS

更新日期：2018-12-19 00:00:00

abstract：:Mitochondrial dynamics are known to have an important role in so-called age-related diseases, including cancer. Mitochondria is an organelle involved in many key cellular functions and responds to physiologic or stress stimuli by adapting its structure and function. Perhaps the most important structural changes involv...

journal_title：Genes

authors： Lima AR,Santos L,Correia M,Soares P,Sobrinho-Simões M,Melo M,Máximo V

更新日期：2018-02-21 00:00:00

abstract：:Interleukin 8 (IL-8) participates in the immune response and has the function of inducing neutrophils to release lysosomal enzymes and eliminate pathogens. This study was to investigate the effect of single nucleotide mutations in the IL-8 gene promoter region on the coccidiosis resistance index. In this study, 180 in...

journal_title：Genes

authors： Wang XH,Yu HL,Zou WB,Mi CH,Dai GJ,Zhang T,Zhang GX,Xie KZ,Wang JY

更新日期：2020-04-27 00:00:00

abstract：:The microRNA (miR)-17 family is widely expressed in mammalian tissues and play important roles in various physiological and pathological processes. Here, the functions of miR-106a-5p, a member of miR-17 family, were explored during myogenic differentiation in C2C12 cell line. First, miR-106a-5p was found to be relativ...

journal_title：Genes

authors： Li X,Zhu Y,Zhang H,Ma G,Wu G,Xiang A,Shi X,Yang GS,Sun S

更新日期：2018-07-02 00:00:00

abstract：:Copy Number Variations (CNVs) and Single Nucleotide Polymorphisms (SNPs) have been the major focus of most large-scale comparative genomics studies to date. Here, we discuss a third, largely ignored, type of genetic variation, namely changes in tandem repeat number. Historically, tandem repeats have been designated as...

journal_title：Genes

authors： Gemayel R,Cho J,Boeynaems S,Verstrepen KJ

更新日期：2012-07-26 00:00:00

abstract：:Cultivation of faba bean (Vicia faba L.) in Tunisia is largely based on improved varieties of the crop. However, a few farmers continue to produce local cultivars or landraces. The National Gene Bank of Tunisia (NGBT) recently launched a collection project for faba bean landraces, with special focus on the regions of ...

journal_title：Genes

authors： Babay E,Khamassi K,Sabetta W,Miazzi MM,Montemurro C,Pignone D,Danzi D,Finetti-Sialer MM,Mangini G

更新日期：2020-02-24 00:00:00

abstract：:Lysosomal storage disorders (LSDs) represent a group of more than 50 severe metabolic diseases caused by the deficiency of specific lysosomal hydrolases, activators, carriers, or lysosomal integral membrane proteins, leading to the abnormal accumulation of substrates within the lysosomes. Numerous mutations have been ...

journal_title：Genes

authors： Dardis A,Buratti E

更新日期：2018-02-06 00:00:00

abstract：:Most of the prescribing and dispensing of medicines happens in primary care. Pharmacogenomics (PGx) is the study and clinical application of the role of genetic variation on drug response. Mounting evidence suggests PGx can improve the safety and/or efficacy of several medications commonly prescribed in primary care. ...

journal_title：Genes

authors： Rollinson V,Turner R,Pirmohamed M

更新日期：2020-11-12 00:00:00

abstract：:This article explores the mechanism of miR-194 on the proliferation and apoptosis of Aβ1-42-transduced hippocampal neurons. Aβ1-42-transduced hippocampal neuron model was established by inducing hippocampal neurons with Aβ1-42. MTT assay and flow cytometry were used to detect the viability and apoptosis of hippocampal...

journal_title：Genes

authors： Wang T,Cheng Y,Han H,Liu J,Tian B,Liu X

更新日期：2019-04-21 00:00:00

abstract：:It is increasingly recognised that lncRNAs play essential regulatory roles in fundamental biological processes and, consequently, that their dysregulation may contribute to major human diseases, including cancer. Better understanding of lncRNA biology may therefore offer new insights into pathogenetic mechanisms and t...

journal_title：Genes

authors： Pickard MR,Williams GT

更新日期：2015-07-07 00:00:00

abstract：:RNA plays complex roles in normal health and disease and is becoming an important target for therapeutic intervention; accordingly, therapeutic strategies that modulate RNA function have gained great interest over the past decade. Antisense oligonucleotides (AOs) are perhaps the most promising strategy to modulate RNA...

journal_title：Genes

authors： Imbert M,Dias-Florencio G,Goyenvalle A

更新日期：2017-01-26 00:00:00

abstract：:Amyloid beta-peptide is produced by the cleavage of amyloid precursor protein by two secretases, a β-secretase, beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) and a γ-secretase. It has been hypothesised that partial inhibition of BACE1 in individuals with a high risk of developing Alzheimer's disease ma...

journal_title：Genes

authors： Chakravarthy M,Veedu RN

更新日期：2019-09-12 00:00:00

abstract：:Transfer RNAs (tRNAs) are essential adaptors that mediate translation of the genetic code. These molecules undergo a variety of post-transcriptional modifications, which expand their chemical reactivity while influencing their structure, stability, and functionality. Chemical modifications to tRNA ensure translational...

journal_title：Genes

authors： Edwards AM,Addo MA,Dos Santos PC

更新日期：2020-08-07 00:00:00

abstract：:The transition from a dormant to a germinating seed represents a crucial developmental switch in the life cycle of a plant. Subsequent transition from a germinating seed to an autotrophic organism also requires a robust and multi-layered control. Seed germination and seedling growth are multistep processes, involving ...

journal_title：Genes

authors： Longo C,Holness S,De Angelis V,Lepri A,Occhigrossi S,Ruta V,Vittorioso P

更新日期：2020-12-31 00:00:00

abstract：:B chromosomes (Bs) are enigmatic additional elements in the genomes of thousands of species of plants, animals, and fungi. How do these non-essential, harmful, and parasitic chromosomes maintain their presence in their hosts, making demands on all the essential functions of their host genomes? The answer seems to be t...

journal_title：Genes

authors： Jones RN

更新日期：2018-07-31 00:00:00

abstract：:Marek's Disease is a lymphoproliferative disease of chickens caused by Marek's Disease Virus. Similar to other herpesviruses, Marek's Disease Virus (MDV) encodes its own small non-coding regulatory RNAs termed microRNAs (miRNAs). We previously found that the expression profile of these viral miRNAs is affected by vacc...

journal_title：Genes

authors： Hicks JA,Liu HC

更新日期：2019-02-05 00:00:00

abstract：:It is well established that embryonic chromosomal abnormalities (both in the number of chromosomes and the structure) account for 50% of early pregnancy losses. However, little is known regarding the potential differences in the incidence and distribution of chromosomal abnormalities between patients with sporadic abo...

journal_title：Genes

authors： Sheng YR,Hou SY,Hu WT,Wei CY,Liu YK,Liu YY,Jiang L,Xiang JJ,Sun XX,Lei CX,Wang HL,Zhu XY

更新日期：2021-01-22 00:00:00

abstract：:Prader⁻Willi syndrome (PWS) is a complex genetic disorder that, besides cognitive impairments, is characterized by hyperphagia, obesity, hypogonadism, and growth impairment. Proprotein convertase subtilisin/kexin type 1 (PCSK1) deficiency, a rare recessive congenital disorder, partially overlaps phenotypically with PW...

journal_title：Genes

authors： Ramos-Molina B,Molina-Vega M,Fernández-García JC,Creemers JW

更新日期：2018-06-07 00:00:00

abstract：:The MinION sequencer has made in situ sequencing feasible in remote locations. Following our initial demonstration of its high performance off planet with Earth-prepared samples, we developed and tested an end-to-end, sample-to-sequencer process that could be conducted entirely aboard the International Space Station (...

journal_title：Genes

authors： Burton AS,Stahl SE,John KK,Jain M,Juul S,Turner DJ,Harrington ED,Stoddart D,Paten B,Akeson M,Castro-Wallace SL

更新日期：2020-01-09 00:00:00

abstract：BACKGROUND:Radiation induces DNA double-strand breaks (DSBs), and chromosome aberrations (CA) form during the DSBs repair process. Several methods have been used to model the repair kinetics of DSBs including the bi-exponential model, i.e., N(t) = N1exp(-t/τ1) + N2exp(-t/τ2), where N(t) is the number of breaks at time ...

journal_title：Genes

authors： Plante I,Slaba T,Shavers Z,Hada M

更新日期：2019-11-16 00:00:00

abstract：:Elite athlete status is a partially heritable trait, as are many of the underpinning physiological, anthropometrical, and psychological traits that contribute to elite performance. In recent years, our understanding of the specific genetic variants that contribute to these traits has grown, such that there is consider...

journal_title：Genes

authors： Pickering C,Kiely J,Grgic J,Lucia A,Del Coso J

更新日期：2019-11-26 00:00:00

abstract：:Shiga toxin-producing Escherichia coli (STEC) are foodborne pathogens associated with outbreaks and hemolytic-uremic syndrome. Cattle and meat foods are the main reservoir and infection source, respectively. Pathogenicity islands (PAIs) play an important role in STEC pathogenicity, and non-locus of the enterocyte effa...

journal_title：Genes

authors： Soledad-Cadona J,Bustamante AV,González J,Mariel-Sanso A

更新日期：2018-02-10 00:00:00

abstract：:During speciation-with-gene-flow, a transition from single-locus to multi-locus processes can occur, as strong coupling of multiple loci creates a barrier to gene flow. Testing predictions about such transitions with empirical data requires building upon past theoretical work and the continued development of quantitat...

journal_title：Genes

authors： Schilling MP,Mullen SP,Kronforst M,Safran RJ,Nosil P,Feder JL,Gompert Z,Flaxman SM

更新日期：2018-05-24 00:00:00