Abstract：
:Elite athlete status is a partially heritable trait, as are many of the underpinning physiological, anthropometrical, and psychological traits that contribute to elite performance. In recent years, our understanding of the specific genetic variants that contribute to these traits has grown, such that there is considerable interest in attempting to utilise genetic information as a tool to predict future elite athlete status. In this review, we explore the extent of the genetic influence on the making of a sporting champion and we describe issues which, at present, hamper the utility of genetic testing in identifying future elite performers. We build on this by exploring what further knowledge is required to enhance this process, including a reflection on the potential learnings from the use of genetics as a disease prediction tool. Finally, we discuss ways in which genetic information may hold utility within elite sport in the future, including guiding nutritional and training recommendations, and assisting in the prevention of injury. Whilst genetic testing has the potential to assist in the identification of future talented performers, genetic tests should be combined with other tools to obtain an accurate identification of those athletes predisposed to succeed in sport. The use of total genotype scores, composed of a high number of performance-enhancing polymorphisms, will likely be one of the best strategies in the utilisation of genetic information to identify talent in sport.
journal_name
Genes (Basel)journal_title
Genesauthors
Pickering C,Kiely J,Grgic J,Lucia A,Del Coso Jdoi
10.3390/genes10120972subject
Has Abstractpub_date
2019-11-26 00:00:00issue
12issn
2073-4425pii
genes10120972journal_volume
10pub_type
杂志文章,评审相关文献
Genes文献大全abstract：:While methods for detecting SNVs and indels in circulating tumor DNA (ctDNA) with hybridization capture-based next-generation sequencing (NGS) have been available, copy number variations (CNVs) detection is more challenging. Here, we present a method enabling CNV detection from a 150-gene panel using a very low amount...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10110926
更新日期：2019-11-14 00:00:00
abstract：:Helicobacter pylori (H. pylori) is one of the main causes of gastric gancer. TNF-related apoptosis-inducing ligand (TRAIL) is a protein able to promote apoptosis in cancer cells, however not in gastric cancer, which presents resistance to apoptosis via TRAIL. It is believed that MicroRNA-106b-5p might be involved in t...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11040393
更新日期：2020-04-05 00:00:00
abstract：:Approximately 150 fungal species are considered as primary pathogens of humans and animals[...]. ...
journal_title：Genes
pub_type： 社论
doi：10.3390/genes10020136
更新日期：2019-02-12 00:00:00
abstract：:Both type 1 and type 2 diabetes are conditions that are associated with the loss of insulin-producing β-cells within the pancreas. An active research therefore aims at regenerating these β-cells with the hope that they could restore euglycemia. The approaches classically used consist in mimicking embryonic development...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes9090448
更新日期：2018-09-07 00:00:00
abstract：:In addition to its wide geographical distribution, osteoglossiform fishes represent one of the most ancient freshwater teleost lineages; making it an important group for systematic and evolutionary studies. These fishes had a Gondwanan origin and their past distribution may have contributed to the diversity present in...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes9060306
更新日期：2018-06-19 00:00:00
abstract：:B chromosomes are enigmatic heritable elements found in the genomes of numerous plant and animal species. Contrary to their broad distribution, most B chromosomes are non-essential. For this reason, they are regarded as genome parasites. In order to be stably transmitted through generations, many B chromosomes exhibit...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes10020123
更新日期：2019-02-08 00:00:00
abstract：:The relationship between variation of the repetitive component of the genome and domestication in plant species is not fully understood. In previous work, variations in the abundance and proximity to genes of long terminal repeats (LTR)-retrotransposons of sunflower (Helianthus annuus L.) were investigated by Illumina...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes9090433
更新日期：2018-08-29 00:00:00
abstract：:In this paper, we present a two-phase microfluidic system capable of incubating and quantifying microbead-based agglutination assays. The microfluidic system is based on a simple fabrication solution, which requires only laboratory tubing filled with carrier oil, driven by negative pressure using a syringe pump. We pr...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes9060281
更新日期：2018-06-04 00:00:00
abstract：:Interleukin 8 (IL-8) participates in the immune response and has the function of inducing neutrophils to release lysosomal enzymes and eliminate pathogens. This study was to investigate the effect of single nucleotide mutations in the IL-8 gene promoter region on the coccidiosis resistance index. In this study, 180 in...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11050476
更新日期：2020-04-27 00:00:00
abstract：:Recently, microfluidic technologies have attracted an enormous amount of interest as potential new tools for a large range of applications including materials synthesis, chemical and biological detection, drug delivery and screening, point-of-care diagnostics, and in-the-field analysis. Their ability to handle extreme...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes9060283
更新日期：2018-06-05 00:00:00
abstract：:Testis cords are the embryonic precursors of the seminiferous tubules. Development of testis cords is a key event during embryonic testicular morphogenesis and is regulated by multiple signaling molecules produced by Sertoli cells. However, the exact nature and the cascade of molecular events underlying testis cord de...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10120974
更新日期：2019-11-26 00:00:00
abstract：:Several transcription factors (TFs) coordinate to regulate expression of specific genes at the transcriptional level. In Arabidopsis thaliana it is estimated that approximately 10% of all genes encode TFs or TF-like proteins. It is important to identify target genes that are directly regulated by TFs in order to under...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes5041115
更新日期：2014-12-19 00:00:00
abstract：:Death investigations often include an effort to establish the postmortem interval (PMI) in cases in which the time of death is uncertain. The postmortem interval can lead to the identification of the deceased and the validation of witness statements and suspect alibis. Recent research has demonstrated that microbes pr...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes9020104
更新日期：2018-02-16 00:00:00
abstract：:At each round of cell division, the DNA must be correctly duplicated and distributed between the two daughter cells to maintain genome identity. In order to achieve proper chromosome replication and segregation, sister chromatids must be recognized as such and kept together until their separation. This process of cohe...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes11080902
更新日期：2020-08-07 00:00:00
abstract：:Modulated electromagnetic fields (wEMFs), as generated by modern communication technologies, have raised concerns about adverse health effects. The International Agency for Research on Cancer (IARC) classifies them as "possibly carcinogenic to humans" (Group 2B), yet, the underlying molecular mechanisms initiating and...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11040347
更新日期：2020-03-25 00:00:00
abstract：:We report the development of a multigene gene expression assay on the BioMark HD platform for the evaluation of immune competence (ImCom) in farmed Atlantic salmon. The first version of the assay included 92 genes selected on the basis of transcriptome analyses in 54 trials that challenged the immune system; annotatio...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11111236
更新日期：2020-10-22 00:00:00
abstract：:Transcriptional reprograming after the exposure of plants to elevated temperatures is a hallmark of stress response which is required for the manifestation of thermotolerance. Central transcription factors regulate the stress survival and recovery mechanisms and many of the core responses controlled by these factors a...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11060655
更新日期：2020-06-16 00:00:00
abstract：:In the frog genus Pseudis, previous works found a sex-linked heteromorphism of the PcP190 satellite DNA in the nucleolus organizer region (NOR)-bearing chromosome pairs of Pseudis bolbodactyla and Pseudis tocantins, which possess a ZZ/ZW sex determination system. A pericentromeric inversion was inferred to have occurr...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10020160
更新日期：2019-02-19 00:00:00
abstract：:Vitellogenin receptors (VgRs) play critical roles in egg formation by transporting vitellogenin (Vg) into oocytes in insects. Although the function of VgR in insects is well studied, the transcriptional regulation of this gene is still unclear. Here, we cloned the promoter of the VgR gene from Bombyx mori (BmVgR), and...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11040394
更新日期：2020-04-06 00:00:00
abstract：:The development of the udder and the milk yield are closely related to the number and vitality of mammary epithelial cells. Many previous studies have proved that non-coding RNAs (ncRNAs) are widely involved in mammary gland development and the physiological activities of lactation. Our laboratory previous sequencing ...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11070718
更新日期：2020-06-28 00:00:00
abstract：:Single-cell RNA sequencing (scRNA-seq) has recently brought new insight into cell differentiation processes and functional variation in cell subtypes from homogeneous cell populations. A lack of prior knowledge makes unsupervised machine learning methods, such as clustering, suitable for analyzing scRNA-seq . However,...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10020098
更新日期：2019-01-29 00:00:00
abstract：:As a major infectious disease in chickens, Newcastle disease virus (NDV) causes considerable economic losses in the poultry industry, especially in developing countries where there is limited access to effective vaccination. Therefore, enhancing resistance to the virus in commercial chickens through breeding is a prom...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11091003
更新日期：2020-08-26 00:00:00
abstract：:The presence and strength of resource competition can influence how organisms adaptively respond to environmental change. Selection may thus reflect a balance between two forces, adaptation to an environmental optimum and evolution to avoid strong competition. While this phenomenon has previously been explored in the ...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11121433
更新日期：2020-11-28 00:00:00
abstract：:Silver-Russell syndrome (SRS) is a rare growth-related genetic disorder that is mainly associated with prenatal and postnatal growth retardation. Molecular causes are not clear in all cases, the most common ones being loss of methylation on chromosome 11p15 (≈50%) and maternal uniparental disomy for chromosome 7 (upd(...
journal_title：Genes
pub_type：
doi：10.3390/genes11121461
更新日期：2020-12-05 00:00:00
abstract：:The heavy impact of obesity on both the population general health and the economy makes clarifying the underlying mechanisms, identifying pharmacological targets, and developing efficient therapies for obesity of high importance. The main struggle facing obesity research is that the underlying mechanistic pathways are...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes11080875
更新日期：2020-07-31 00:00:00
abstract：:Plant genomes generated by Sanger and Next Generation Sequencing (NGS) have provided insight into species diversity and evolution. However, Sanger sequencing is limited in its applications due to high cost, labor intensity, and low throughput, while NGS reads are too short to resolve abundant repeats and polyploidy, l...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes9010006
更新日期：2017-12-28 00:00:00
abstract：:RabGTPase activating proteins (RabGAP) are responsible for directing the deactivation of vesicular trafficking master regulators associated to plant development, the RabGTPase proteins. Recently, RabGAPs were identified in Arabidopsis and rice, but studies were not yet reported in tomato. Herein, we identified 24 RabG...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10090638
更新日期：2019-08-23 00:00:00
abstract：:Magnaportheoryzae is a devastating plant pathogen, which has a detrimental impact on rice production worldwide. Despite its agronomical importance, some newly-emerging pathotypes often overcome race-specific disease resistance rapidly. It is thus desirable to develop a novel strategy for the long-lasting resistance of...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes8100241
更新日期：2017-09-26 00:00:00
abstract：:Brycon is an important group of Neotropical fish and the principal genus of the family Bryconidae, with 44 valid species that are found in some Central American rivers and practically all the major hydrographic basins of South America. These fish are medium to large in size, migratory, omnivorous, important seed dispe...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10090639
更新日期：2019-08-23 00:00:00
abstract：:Prader⁻Willi syndrome (PWS) is a complex genetic disorder that, besides cognitive impairments, is characterized by hyperphagia, obesity, hypogonadism, and growth impairment. Proprotein convertase subtilisin/kexin type 1 (PCSK1) deficiency, a rare recessive congenital disorder, partially overlaps phenotypically with PW...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes9060288
更新日期：2018-06-07 00:00:00
