Environmental role of pathogenic traits in Vibrio cholerae.

Abstract:

:Vibrio cholerae is a natural inhabitant of aquatic ecosystems. Some strains of V. cholerae can colonize the human host and cause cholera, a profuse watery diarrhea. The major pathogenicity factors and virulence regulators of V. cholerae are either encoded in mobile genetic elements acquired in the environment (e.g. pathogenicity islands or lysogenic phages) or in the core genome. Several lines of evidence indicate that the emergence of numerous virulence traits of V. cholerae occurred in its natural environment due to biotic and abiotic pressures. Here, we discuss the connection between the human host and the potential ecological role of these virulent traits. Unraveling these connections will help us understand the emergence of this organism and other facultative bacterial pathogens.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Sakib SN,Reddi G,Almagro-Moreno S

doi

10.1128/JB.00795-17

subject

Has Abstract

pub_date

2018-03-26 00:00:00

pages

e00795-17

issue

15

eissn

0021-9193

issn

1098-5530

pii

JB.00795-17

journal_volume

200

pub_type

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