Contractile heterogeneity in ventricular myocardium.

abstract：:Total cellular calcium levels do not change when 3T3-4a cells stop proliferating due to serum depletion, or when serum-arrested quiescent cells are incubated for up to 44 hours in calcium-deficient medium (approximately 10 micrometer Ca++). Upon stimulation with dialyzed serum cells enter S and progress through at lea...

journal_title：Journal of cellular physiology

authors： Paul D,Ristow HJ

更新日期：1979-01-01 00:00:00

abstract：:Over-production and activation of osteoclasts is a common feature of osteolytic conditions such as osteoporosis, tumor-associated osteolysis, and inflammatory bone erosion. Cyanidin Chloride, a subclass of anthocyanin, displays antioxidant and anti-carcinogenesis properties, but its role in osteoclastic bone resorptio...

journal_title：Journal of cellular physiology

authors： Cheng J,Zhou L,Liu Q,Tickner J,Tan Z,Li X,Liu M,Lin X,Wang T,Pavlos NJ,Zhao J,Xu J

更新日期：2018-03-01 00:00:00

abstract：:The application of the phenomenon of premature chromosome condensation for cell cycle analysis in HeLa and CHO cells has been examined. Random populations of HeLa and CHO cells pulse labelled with H3-TdR were separately fused with mitotic HeLa cells using U.V. inactivated Sendai virus. The resulting prematurely conden...

journal_title：Journal of cellular physiology

authors： Rao PN,Wilson B,Puck TT

更新日期：1977-04-01 00:00:00

abstract：:Dose-response curves for the inhibition of heterogeneous nuclear RNA (hnRNA) synthesis in HeLa cells by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB; 5-100 microM; 30 min) are biphasic and indicate the existence of two subpopulations of hnRNA molecules, one highly sensitive and the other completely resistant,...

journal_title：Journal of cellular physiology

authors： Tamm I

更新日期：1983-07-01 00:00:00

abstract：:A protein carboxyl methyltransferase (PCMT), which specifically modifies atypical protein L-isoaspartyl and D-aspartyl residues, is widely distributed in eucaryotic cells, but the factors that regulate its activity in vivo have not been identified. It has been proposed that the PCMT initiates the repair of structurall...

journal_title：Journal of cellular physiology

authors： Ladino CA,O'Connor CM

更新日期：1992-11-01 00:00:00

abstract：:Osteoclasts and macrophages share progenitors that must receive decisive lineage signals driving them into their respective differentiation routes. Macrophage colony stimulation factor M-CSF is a common factor; bone is likely the stimulus for osteoclast differentiation. To elucidate the effect of both, shared mouse bo...

journal_title：Journal of cellular physiology

authors： De Vries TJ,Schoenmaker T,Aerts D,Grevers LC,Souza PP,Nazmi K,van de Wiel M,Ylstra B,Lent PL,Leenen PJ,Everts V

更新日期：2015-01-01 00:00:00

abstract：:The role of cyclic adenosine monophosphate (cAMP) is poorly understood in the regulation of normal and abnormal hepatic cell growth. In this study, we examined the regulation of intracellular cAMP levels and its effect on nuclear cAMP responsive elements (CREs) in a rat model of hepatocellular carcinoma (HCC). Tumorig...

journal_title：Journal of cellular physiology

authors： Kovach SJ,Price JA,Shaw CM,Theodorakis NG,McKillop IH

更新日期：2006-02-01 00:00:00

abstract：:Acute lung injury (ALI) is a severe acute inflammatory reaction of the lungs caused by a variety of factors, which can lead to a high mortality rate. MicroRNAs are a novel therapeutic molecule that play a vital role in many diseases. However, its mechanism of action in lipopolysaccharide (LPS)-induced mouse ALI is not...

journal_title：Journal of cellular physiology

authors： Guo S,Chen Y,Liu J,Yang J,Yang C,Zhang T,Jiang K,Wu Z,Shaukat A,Deng G

更新日期：2019-12-01 00:00:00

abstract：:The genetic factors known to be involved in the final realization of beta-glucuronidase activity in mice are considered from the standpoint of structural genes determining the catalytic activity of enzyme molecules as well as the recognition features of enzyme molecules that identify them for subsequent processing by ...

journal_title：Journal of cellular physiology

authors： Paigen K,Swank RT,Tomino S,Ganschow RE

更新日期：1975-04-01 00:00:00

abstract：:microRNAs (miRNAs) and circular RNAs (circRNAs) are important for endometrial receptivity establishment and embryo implantation in mammals. miR-34a and miR-34c are highly expressed in caprine receptive endometrium (RE). Herein, the functions and mechanisms of miR-34a/c in caprine endometrial epithelial cell (CEEC) apo...

journal_title：Journal of cellular physiology

authors： Liu X,Zhang L,Yang L,Cui J,Che S,Liu Y,Han J,An X,Cao B,Song Y

更新日期：2020-12-01 00:00:00

abstract：:We have analyzed the regulation of transcription of integrated SV40 DNA and of five cellular genes during the cell cycle of two lines of SV40 transformed mouse 3T3 cells. These cells (ts SV3T3) are temperature sensitive for the expression of the transformed phenotype and at the nonpermissive temperature (39 degrees C)...

journal_title：Journal of cellular physiology

authors： La Bella F,Brown EH,Basilico C

更新日期：1983-10-01 00:00:00

abstract：:Previously, serum miR-188-5p is differentially expressed in breast cancer, but the diagnostic potential of circulating miR-188-5p as well as its regulatory mechanism in breast cancer remain uncertain. Herein, serum miR-188-5p was detected by real-time polymerase chain reaction in patients with breast cancer, breast fi...

journal_title：Journal of cellular physiology

authors： Wang M,Zhang H,Yang F,Qiu R,Zhao X,Gong Z,Yu W,Zhou B,Shen B,Zhu W

更新日期：2020-05-01 00:00:00

abstract：:In the present study, we have employed a unique breast cancer cell line (Met-1, which was derived from a high metastatic potential tumor in transgenic mice expressing polyomavirus middle T oncogene) to study the role of CD44 variant isoform(s) in the regulation of metastatic breast tumor cell behavior. The results of ...

journal_title：Journal of cellular physiology

authors： Bourguignon LY,Gunja-Smith Z,Iida N,Zhu HB,Young LJ,Muller WJ,Cardiff RD

更新日期：1998-07-01 00:00:00

abstract：:Aberrant proliferation of vascular smooth muscle cells (VSMC) is a critical contributor to the pathogenesis of atherosclerosis (AS). Our previous studies have demonstrated that apelin-13/APJ confers a proliferative response in VSMC, however, its underlying mechanism remains elusive. In this study, we aimed to investig...

journal_title：Journal of cellular physiology

authors： He L,Zhou Q,Huang Z,Xu J,Zhou H,Lv D,Lu L,Huang S,Tang M,Zhong J,Chen JX,Luo X,Li L,Chen L

更新日期：2019-06-01 00:00:00

abstract：:Protein kinase C and mitogen-activated protein (MAP) kinase are expressed in all smooth muscle cells and believed to be important in several physiologically relevant properties of this muscle. Our goal was to determine if protein kinase C and MAP kinase are activated by a simple increase in cellular Ca(2+) and to dete...

journal_title：Journal of cellular physiology

authors： Katoch SS,Su X,Moreland RS

更新日期：1999-05-01 00:00:00

abstract：:The non-POU-domain-containing octamer binding protein (NONO; also known as p54nrb) has various nuclear functions ranging from transcription, RNA splicing, DNA synthesis and repair. Although tyrosine phosphorylation has been proposed to account for the multi-functional properties of p54nrb, direct evidence on p54nrb as...

journal_title：Journal of cellular physiology

authors： Lee AR,Hung W,Xie N,Liu L,He L,Dong X

更新日期：2017-04-01 00:00:00

abstract：:We report that cultured vascular endothelial cells release into the culture medium a vasoconstrictor peptide, a substance we call an endothelium-derived constricting factor (EDCF). Conditioned medium from cultured bovine aortic and pulmonary artery endothelial cells caused sustained, dose-dependent isometric constrict...

journal_title：Journal of cellular physiology

authors： O'Brien RF,Robbins RJ,McMurtry IF

更新日期：1987-08-01 00:00:00

abstract：:Interleukin-1 is a proinflammatory and immunomodulatory cytokine that plays a crucial role in inflammatory diseases of the skin, including bacterial infections, bullous diseases, UV damage, and especially psoriasis. To characterize the molecular effects of IL-1 in epidermis, we defined the transcriptional changes in h...

journal_title：Journal of cellular physiology

authors： Yano S,Banno T,Walsh R,Blumenberg M

更新日期：2008-01-01 00:00:00

abstract：:In vitro generation of HSCs from pluripotent stem cells (PSCs) can be regarded as novel therapeutic approaches for replacing bone marrow (BM) transplantation without immune rejection or graft versus host disease(GVHD). To date, many differentiation approaches have been evaluated in terms of directing PSCs toward diffe...

journal_title：Journal of cellular physiology

authors： Shan W,Wang B,Xu Y,Li X,Li X,Wang H,Lin Y,Tie R,Zhao Q,Wang J,Zheng W,Hu Y,Shi J,Yu X,Huang H

更新日期：2018-01-31 00:00:00

abstract：:Osteoblasts are terminally differentiated cells with mesenchymal origins, known to possess pivotal roles in sustaining bone microstructure and homeostasis. These cells are implicated in the pathophysiology of various bone disorders, especially osteoporosis. Over the last few decades, strategies to impede bone resorpti...

journal_title：Journal of cellular physiology

authors： Aslani S,Abhari A,Sakhinia E,Sanajou D,Rajabi H,Rahimzadeh S

更新日期：2019-06-01 00:00:00

abstract：:Spontaneously arising, TGF beta 1-resistant colonies were isolated directly from the soft agarose plates of MOSER human colon carcinoma cells grown in the presence of TGF beta 1 but in the absence of serum. The colonies were cloned by limiting dilution and screened in a monolayer proliferation assay for sensitivity to...

journal_title：Journal of cellular physiology

authors： Zhou GH,Sechrist GL,Brattain MG,Mulder KM

更新日期：1995-12-01 00:00:00

abstract：:It has been shown that the insulin-like growth factor (IGF-I) gene is spliced in response to mechanical signals producing forms of IGF-I which have different actions. In order to study how mechanical signals influence this gene splicing in developing muscle, C2C12 cells were grown in three-dimensional (3D) culture and...

journal_title：Journal of cellular physiology

authors： Cheema U,Brown R,Mudera V,Yang SY,McGrouther G,Goldspink G

更新日期：2005-01-01 00:00:00

abstract：:We have previously shown that 24,25-(OH)2D3 plays a major role in resting zone (RC) chondrocyte differentiation and that this vitamin D metabolite regulates protein kinase C (PKC). The aim of the present study was to identify the signal transduction pathway used by 24,25-(OH)2D3 to stimulate PKC activation. Confluent,...

journal_title：Journal of cellular physiology

authors： Helm S,Sylvia VL,Harmon T,Dean DD,Boyan BD,Schwartz Z

更新日期：1996-12-01 00:00:00

abstract：:The cancer stem cell (CSC) model encompasses an advantageous paradigm that in recent decades provides a better elucidation for many important biological aspects of cancer initiation, progression, metastasis, and, more important, development of multidrug resistance (MDR). Such several other hematological malignancies a...

journal_title：Journal of cellular physiology

authors： Mihanfar A,Aghazadeh Attari J,Mohebbi I,Majidinia M,Kaviani M,Yousefi M,Yousefi B

更新日期：2019-04-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) is a hematopoietic stem cell disorder caused by the oncogenic activity of the Bcr-Abl protein, a deregulated tyrosine kinase. Calcium may act directly on cellular enzymes and in conjunction with other cellular metabolites, such as cyclic nucleotides, to regulate cell functions. Alteratio...

journal_title：Journal of cellular physiology

authors： Ciarcia R,d'Angelo D,Pacilio C,Pagnini D,Galdiero M,Fiorito F,Damiano S,Mattioli E,Lucchetti C,Florio S,Giordano A

更新日期：2010-08-01 00:00:00

abstract：:We have measured endogenous and induced rates of 70-kD, 89-kD, and 110-kD heat shock proteins in highly pure G1-, S-, or G2-M phase fractions of Chinese hamster fibroblasts (CHO) separated by fluorescence-activated cell sorting (FACS). Relative rates of synthesis of all three polypeptides as measured by two-dimensiona...

journal_title：Journal of cellular physiology

authors： Rice G,Laszlo A,Li G,Gray J,Dewey W

更新日期：1986-02-01 00:00:00

abstract：:We examined the effects of thrombin on thromboxane generation by sheep neutrophils and lymphocytes in vitro. Physiological concentration of thrombin (50 nM) resulted in thromboxane B2 generation from both neutrophils and lymphocytes, which was comparable to that obtained with zymosan activated serum challenge of the c...

journal_title：Journal of cellular physiology

authors： Bizios R,Lai L,Fenton JW 2nd,Malik AB

更新日期：1987-08-01 00:00:00

abstract：:The smooth muscle cell population in major arteries of humans and experimental animals is heterogeneous with regard to cellular DNA content. A proportion of cells has polyploid DNA content and this proportion increases with normal aging and with hypertension. We have isolated pure populations of rat aortic smooth musc...

journal_title：Journal of cellular physiology

authors： Rosen EM,Goldberg ID,Shapiro HM,Zoller LC,Myrick KV,Levenson SE,Halpin PA

更新日期：1985-12-01 00:00:00

abstract：:Epithelial cells are important components of the thymus microenvironment and are involved in thymocyte differentiation. The production and secretion of sulfated glycosaminoglycans by these cells grown in culture were investigated using labeling with radioactive 35S-Na2SO4 and 3H-glucosamine. The major glycosaminoglyca...

journal_title：Journal of cellular physiology

authors： Werneck CC,Oliveira-Dos-Santos AJ,Silva LC,Villa-Verde DM,Savino W,Mourão PA

更新日期：1999-01-01 00:00:00

abstract：:Ebp1, an ErbB-3 binding protein, inhibits the proliferation and induces the differentiation of human breast cancer cells. The mechanisms of these effects are unknown. Rb, the product of the retinoblastoma gene, is an important modulator of cell cycle progression and cellular differentiation. We report that Rb is a bin...

journal_title：Journal of cellular physiology

authors： Xia X,Cheng A,Lessor T,Zhang Y,Hamburger AW

更新日期：2001-05-01 00:00:00