miR-497a-5p attenuates lipopolysaccharide-induced inflammatory injury by targeting IRAK2.

Abstract:

:Acute lung injury (ALI) is a severe acute inflammatory reaction of the lungs caused by a variety of factors, which can lead to a high mortality rate. MicroRNAs are a novel therapeutic molecule that play a vital role in many diseases. However, its mechanism of action in lipopolysaccharide (LPS)-induced mouse ALI is not clear. The study aimed to investigate the mechanism of action of miR-497 in LPS-induced ALI. As a result, it was found that the expression of miR-497 in the inflammatory reaction showed a decrease in time and dose trends. Importantly, miR-497 reduced LPS-induced expression levels of related inflammatory factors. In addition, we also demonstrated that IRAK2 is a direct target molecule of miR-497. Interestingly, we further found that miR-497 inhibits the expression of IRAK2 by targeting IRAK2-3'UTR. Therefore, miR-497 can partially negatively regulate the activation of IRAK2-NF-κB pathway in LPS-induced inflammatory responses.

journal_name

J Cell Physiol

authors

Guo S,Chen Y,Liu J,Yang J,Yang C,Zhang T,Jiang K,Wu Z,Shaukat A,Deng G

doi

10.1002/jcp.28850

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

22874-22883

issue

12

eissn

0021-9541

issn

1097-4652

journal_volume

234

pub_type

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