Transcriptional responses of human epidermal keratinocytes to cytokine interleukin-1.

abstract：:Generation of reactive oxygen species (ROS) is a common event in the pathogenesis of acute lung injury. Endothelial cells may be both a target and a source of the ROS. Exposure of bovine pulmonary endothelial cells (BPAEC) to lipopolysaccharide (LPS) has been shown to result in intracellular generation of both ROS and...

journal_title：Journal of cellular physiology

authors： Mitchell J,Jiang H,Berry L,Meyrick B

更新日期：1996-11-01 00:00:00

abstract：:We have described recently that expression of CD44 exon v10 (CD44v10) is down-regulated upon metastasis of squamous cell carcinoma, whereas it is up-regulated in skin metastases of malignant melanoma. The striking regulation of CD44v10 prompted us to generate a murine CD44v10-specific monoclonal antibody to define exp...

journal_title：Journal of cellular physiology

authors： Rösel M,Seiter S,Zöller M

更新日期：1997-06-01 00:00:00

abstract：:A factor, termed neutrophil alkaline phosphatase-inducing factor (NAP-IF), that has the capacity to increase the NAP activity of granulocytes was characterized by using two samples: cystic fluid (CF) and conditioned medium of a tumor cell line (T3M5). The molecular weight of NAP-IF was shown to be between 13,000 and 4...

journal_title：Journal of cellular physiology

authors： Sato N,Asano S,Mori M,Ueyama Y,Sugano K,Ohsawa N,Takaku F

更新日期：1985-08-01 00:00:00

abstract：:Suppression of PKC activity can selectively induce apoptosis in cells expressing a constitutively activated p21Ras protein. We demonstrate that continued expression of p21Ras activity is required in PKC-mediated apoptosis because farnesyltransferase inhibitors abrogated the loss of viability in p21Ras-transformed cell...

journal_title：Journal of cellular physiology

authors： Liou JS,Chen JS,Faller DV

更新日期：2004-02-01 00:00:00

abstract：:Genomic imprinting in gametogenesis marks a subset of mammalian genes for parent-of-origin-dependent monoallelic expression in the offspring. Embryological and classical genetic experiments in mice that uncovered the existence of genomic imprinting nearly two decades ago produced abnormalities of growth or behavior, w...

journal_title：Journal of cellular physiology

authors： Tycko B,Morison IM

更新日期：2002-09-01 00:00:00

abstract：:Transient Receptor Potential Vanilloid type 1 channel (TRPV1) is an important endogenous transducer of noxious heat and chemical stimuli and is required during development of inflammatory hypersensitivity. The transcription factor Runx1 is known to play a relevant role in sensory neuron differentiation as it controls ...

journal_title：Journal of cellular physiology

authors： Ugarte GD,Diaz E,Biscaia M,Stehberg J,Montecino M,van Zundert B

更新日期：2013-04-01 00:00:00

abstract：:Several hydrolase activities characteristic of the apical brush border membrane of renal proximal tubule, leucine aminopeptidase, gamma-glutamyl transpeptidase, alkaline phosphatase, maltase, and trehalase, were identified in cultures of the LLC-PK1 kidney epithelial cell line. A coordinate increase in activities of t...

journal_title：Journal of cellular physiology

authors： Yoneyama Y,Lever JE

更新日期：1984-10-01 00:00:00

abstract：:Interleukin (IL)-8 is released both in visceral adipose tissue and in contracting skeletal muscles. In this study, we examined cellular pathways associated with muscle hypertrophy, chosen on the basis of microRNA profiling, in differentiating rat primary skeletal muscle cells (RSkMC) treated with IL-8 (1 ng/ml) for 11...

journal_title：Journal of cellular physiology

authors： Milewska M,Domoradzki T,Majewska A,Błaszczyk M,Gajewska M,Hulanicka M,Ciecierska A,Grzelkowska-Kowalczyk K

更新日期：2019-11-01 00:00:00

abstract：:Diabetic nephropathy (DN) is one of the most serious and dangerous chronic complications caused by diabetes mellitus, and the identification and development of novel biomarkers could be beneficial for the diagnosis and prognosis of DN patients. This study focused on researching the differently expressed pattern of the...

journal_title：Journal of cellular physiology

authors： Song X,Gong M,Chen Y,Liu H,Zhang J

更新日期：2019-02-01 00:00:00

abstract：:Nicotinamide adenine dinucleotide phosphate [NAD(P)H] oxidase complex has been shown to be involved in the process of glucose-stimulated insulin secretion (GSIS). In this study, we examined the effect of palmitic acid on superoxide production and insulin secretion by rat pancreatic islets and the mechanism involved. R...

journal_title：Journal of cellular physiology

authors： Graciano MF,Santos LR,Curi R,Carpinelli AR

更新日期：2011-04-01 00:00:00

abstract：:High temperature requirement A1 (HTRA1) is a serine protease playing a modulatory role in various cell processes, particularly in the regulation of transforming growth factor-β (TGF-β) signaling. A deleterious role in late-onset cerebral small vessel diseases (CSVDs) of heterozygous HTRA1 mutations, otherwise causativ...

journal_title：Journal of cellular physiology

authors： Fasano A,Formichi P,Taglia I,Bianchi S,Di Donato I,Battisti C,Federico A,Dotti MT

更新日期：2020-10-01 00:00:00

abstract：:A rat pheochromocytoma cell line (PC12 cells) was used as a model to investigate the role of calmodulin and its multiple mRNAs in NGF-induced neuronal differentiation. The effect of NGF on the degree of differentiation was assayed using a simple differentiation scoring system. Significant increases in the differentiat...

journal_title：Journal of cellular physiology

authors： Bai G,Weiss B

更新日期：1991-12-01 00:00:00

abstract：:Tumor suppressor pRb2/p130 gene belongs to the retinoblastoma (Rb) gene family, which also includes pRb/p105 and pRb/p107. The members of the Rb gene family have attracted a great deal of interest because of their essential role in regulating cell cycle and, consequently, cell proliferation. This mini review discusses...

journal_title：Journal of cellular physiology

authors： Giordano A,Rossi A,Romano G,Bagella L

更新日期：2007-11-01 00:00:00

abstract：:Radiotherapy remains a prime approach to adjuvant therapies in patients with early and advanced breast cancer. In spite of therapeutic success, metastatic progression in patients undergoing therapy, limits its application. However, effective therapeutic strategies to understand the cellular and molecular machinery in ...

journal_title：Journal of cellular physiology

authors： Rajput S,Kumar BN,Banik P,Parida S,Mandal M

更新日期：2015-03-01 00:00:00

abstract：:Endothelin (ET)-1 was originally characterized as a potent vasoconstrictor peptide secreted by vascular endothelial cells. It possesses a wide range of biological activities within the cardiovascular system and in other organs, including the brain. Also secreted by endothelial cells, nitric oxide (NO), has recently be...

journal_title：Journal of cellular physiology

authors： Durieu-Trautmann O,Fédérici C,Créminon C,Foignant-Chaverot N,Roux F,Claire M,Strosberg AD,Couraud PO

更新日期：1993-04-01 00:00:00

abstract：:Previous studies have indicated that intracellular Ca2+ is involved in fetal bovine serum (FBS)- or growth factor (GF)-stimulated Na+ influx in human foreskin fibroblasts (HSWP). In the present study, 45Ca2+ efflux from serum-deprived HSWP cells was measured in response to 10% FBS or GF [lys-bradykinin, vasopressin, e...

journal_title：Journal of cellular physiology

authors： Owen NE,Villereal ML

更新日期：1983-10-01 00:00:00

abstract：:The amino acid pools in Chinese hamster lung V79 cells were measured as a function of time during hyperthermic exposure at 40.5 degrees and 45.0 degrees C. Sixteen of the 20 protein amino acids were present in sufficient quantity to measure accurately. The total amino acid pool and all individual amino acids, except g...

journal_title：Journal of cellular physiology

authors： Goh CJ,Dumbroff EB,Lepock JR

更新日期：1988-04-01 00:00:00

abstract：:We have investigated the effects of aging on parathyroid hormone (PTH) modulation of intracellular calcium homeostasis and their relationship to signal transduction pathways in isolated rat duodenal cells (enterocytes). PTH (10(-8)-10(-9) M) increased enterocyte (45)Ca(2+) influx and intracellular Ca(2+) concentration...

journal_title：Journal of cellular physiology

authors： Massheimer V,Picotto G,Boland R,De Boland AR

更新日期：2000-03-01 00:00:00

abstract：:Calcium-activated nucleotidase 1 (CANT1, belongs to the apyrase family, is widely expressed in various organs. However, the biological function of CANT1 remains poorly explored. In this study, we aimed to investigate the expression profile and functions of CANT1 in clear cell renal cell carcinoma (ccRCC). Our data sho...

journal_title：Journal of cellular physiology

authors： Liu X,Yang Z,Luo X,Luo J,Fu W,Fang Z,Xia D,Li L,Xu J

更新日期：2019-12-01 00:00:00

abstract：:Factors inhibiting cell growth have been isolated from different cell types. However, little information is available concerning their mode of action. A novel growth inhibitory factor of 45 kDa (IDF45) was recently purified to homogeneity from medium conditioned by 3T3 cells. This molecule was able to inhibit DNA synt...

journal_title：Journal of cellular physiology

authors： Delbe J,Villaudy J,Blat C,Desauty G,Golde A,Harel L

更新日期：1990-02-01 00:00:00

abstract：:Cardiac hypertrophy (CH) has become a huge threat to human health. Recent years, long noncoding RNAs (lncRNAs) have been studied in human diseases, including CH. According to bioinformatics analysis, 10 lncRNAs possibly involved in the progression of CH were screened out. Among which, lncRNA SYNE1 antisense RNA 1 (SYN...

journal_title：Journal of cellular physiology

authors： Wang Y,Cao R,Yang W,Qi B

更新日期：2019-08-01 00:00:00

abstract：:During human pregnancy, the trophoblast develops from differentiation of cytotrophoblast cells into an endocrine active syncytiotrophoblast. In culture, isolated mononuclear cytotrophoblasts aggregate and then fuse to form a syncytium, reproducing the in vivo process. In this study, we examined the effect of low oxyge...

journal_title：Journal of cellular physiology

authors： Alsat E,Wyplosz P,Malassiné A,Guibourdenche J,Porquet D,Nessmann C,Evain-Brion D

更新日期：1996-08-01 00:00:00

abstract：:The Pur proteins are an ancient family of sequence-specific single-stranded nucleic acid-binding proteins. They bind a G-rich element in either single- or double-stranded nucleic acids and are capable of displacing the complementary C-rich strand. Recently several reports have described Pur family member knockouts, mu...

journal_title：Journal of cellular physiology

authors： Johnson EM,Daniel DC,Gordon J

更新日期：2013-05-01 00:00:00

abstract：:The effect of retinoic acid on human fibroblasts was studied in a cell culture model of chronologic aging and photoaging. During early exponential phase, all trans-retinoic acid significantly stimulated growth rate of adult arm-derived dermal fibroblasts but not of newborn or adult foreskin-derived fibroblasts. Retino...

journal_title：Journal of cellular physiology

authors： Stanulis-Praeger BM,Gilchrest BA

更新日期：1989-04-01 00:00:00

abstract：:Adenosine is an ubiquitous nucleoside present in all body cells. It is released from metabolically active or stressed cells and subsequently acts as a regulatory molecule through binding to specific A1, A2A, A2B and A3 cell surface receptors. The synthesis of agonists and antagonists to the adenosine receptors and the...

journal_title：Journal of cellular physiology

authors： Ohana G,Bar-Yehuda S,Barer F,Fishman P

更新日期：2001-01-01 00:00:00

abstract：:We examined the interaction between OSU-03012 (also called AR-12) with phosphodiesterase 5 (PDE5) inhibitors to determine the role of the chaperone glucose-regulated protein (GRP78)/BiP/HSPA5 in the cellular response. Sildenafil (Viagra) interacted in a greater than additive fashion with OSU-03012 to kill stem-like GB...

journal_title：Journal of cellular physiology

authors： Booth L,Roberts JL,Tavallai M,Nourbakhsh A,Chuckalovcak J,Carter J,Poklepovic A,Dent P

更新日期：2015-08-01 00:00:00

abstract：:High potassium concentrations altered the morphology and the ability to grow in soft agar in 6m2 cells, a clone of rat kidney cells infected with a temperature-sensitive mutant of Moloney sarcoma virus. Approximately 60% of cells exhibited normal morphology in the presence of 94.8 mM potassium in isotonic medium at th...

journal_title：Journal of cellular physiology

authors： Lai CN,Becker FF

更新日期：1985-11-01 00:00:00

abstract：:Calreticulin is an ER calcium-storage protein, which influences gene expression and cell adhesion. In this study, we analysed the differences in adhesive properties of calreticulin under- and overexpressing fibroblasts in relation to the calmodulin- and calcium/calmodulin-dependent kinase II (CaMK II)-dependent signal...

journal_title：Journal of cellular physiology

authors： Szabo E,Papp S,Opas M

更新日期：2007-10-01 00:00:00

abstract：:Immunotherapy has caused a paradigm shift in the treatment of several malignancies, particularly the blockade of programmed death-1 (PD-1) and its specific receptor/ligand PD-L1 that have revolutionized the treatment of a variety of malignancies, but significant durable responses only occur in a small percentage of pa...

journal_title：Journal of cellular physiology

authors： Rahimi Kalateh Shah Mohammad G,Ghahremanloo A,Soltani A,Fathi E,Hashemy SI

更新日期：2020-07-01 00:00:00

abstract：:Tight junctions govern the paracellular permeability of endothelial and epithelial cells. Aberrations of tight junction function are an early and key event during the vascular spread of cancer and inflammation. This study sought to determine the role of estrogen in the regulation of tight junctions and expression of m...

journal_title：Journal of cellular physiology

authors： Ye L,Martin TA,Parr C,Harrison GM,Mansel RE,Jiang WG

更新日期：2003-08-01 00:00:00