M-CSF priming of osteoclast precursors can cause osteoclastogenesis-insensitivity, which can be prevented and overcome on bone.

abstract：:Skeletal muscle atrophy/wasting is associated with impaired protein metabolism in diverse physiological and pathophysiological conditions. Elevated levels of reactive oxygen species (ROS), disturbed redox status, and weakened antioxidant defense system are the major contributing factors toward atrophy. Regulation of p...

journal_title：Journal of cellular physiology

authors： Kaur N,Gupta P,Saini V,Sherawat S,Gupta S,Dua A,Kumar V,Injeti E,Mittal A

更新日期：2019-05-01 00:00:00

abstract：:Terminal deoxynucleotidyl transferase (TdT) is a template-independent DNA polymerase that is transiently expressed during the normal development of T and B lymphocytes. Phorbol 12-myristate 13-acetate (PMA) has been reported to induce maturation-like changes, including the loss of TdT, in many leukemic cell lines. We ...

journal_title：Journal of cellular physiology

authors： Beland JL,Yuille MA,Hugunin M,Zhang XM,Silverstone AE

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND:Patients with chronic kidney disease (CKD) have a severe vitamin D deficiency and increasing epidemiological data suggesting that this deficiency may play a role in overall morbidity and mortality associated with CKD. It is known that vitamin D regulates the immune system, however, in dialysis patients this ...

journal_title：Journal of cellular physiology

authors： Almeida ACSF,Siqueira MC,Bonan NB,Dambiski A,Bertuzzo G,Moreno-Amaral AN,Barreto FC

更新日期：2019-02-25 00:00:00

abstract：:CSF-1 is a hemopoietic growth factor that specifically regulates the survival, proliferation, and differentiation of mononuclear phagocytic cells. Populations of adherent bone marrow-derived macrophages (BMM) devoid of CSF-1 producing cells were used to study regulation by CSF-1 of macrophage entry into S phase. More ...

journal_title：Journal of cellular physiology

authors： Tushinski RJ,Stanley ER

更新日期：1985-02-01 00:00:00

abstract：:The presence of an appropriate number of viable cells is prerequisite for successive differentiation during chondrogenesis. Chondrogenic differentiation has been reported to be influenced by mechanical stimuli. This research aimed to study the effects of cyclic compressive stress on cell viability of rat bone marrow-d...

journal_title：Journal of cellular physiology

authors： Wang Y,Wang J,Bai D,Song J,Ye R,Zhao Z,Lei L,Hao J,Jiang C,Fang S,An S,Cheng Q,Li J

更新日期：2013-09-01 00:00:00

abstract：:The Belgrade rat has a hypochromic, microcytic anemia inherited as an autosomal recessive mutation. Although transferrin binds normally to reticulocytes and internalizes normally, iron accumulation into cells and heme is much slower than normal. We have investigated the role of the transferrin cycle in this mutant by ...

journal_title：Journal of cellular physiology

authors： Garrick LM,Gniecko K,Hoke JE,al-Nakeeb A,Ponka P,Garrick MD

更新日期：1991-03-01 00:00:00

abstract：:We recently reported that peptidoglycan (PGN), a cell wall component of the Gram-positive bacterium, induces NF-κB activation and microglia activation. However, PGN-regulated AP-1 activation and cytokine expression in microglia remains unclear. This study investigated how PGN influences the signaling pathway involved ...

journal_title：Journal of cellular physiology

authors： Lin HY,Tang CH,Chen JH,Chuang JY,Huang SM,Tan TW,Lai CH,Lu DY

更新日期：2011-06-01 00:00:00

abstract：:The Giemsa banding pattern of the chromosomes has been analyzed in a line of transformed golden hamster cells, revertant and re-revertant cells and their tumors. The transformed and re-revertant cells were malignant in vivo and had gained an additional chromosome 5(7). Revertants with a suppression of malignancy lost ...

journal_title：Journal of cellular physiology

authors： Bloch-Shtacher N,Sachs L

更新日期：1976-01-01 00:00:00

abstract：:Cholesterol is an important component for cell physiology. It regulates the fluidity of cell membranes and determines the physical and biochemical properties of proteins. In the central nervous system, cholesterol controls synapse formation and function and supports the saltatory conduction of action potential. In rec...

journal_title：Journal of cellular physiology

authors： Cartocci V,Servadio M,Trezza V,Pallottini V

更新日期：2017-02-01 00:00:00

abstract：:Mouse keratinocytes are induced to differentiate in vitro by elevating the level of extracellular calcium from 0.05 mM, where keratinocytes express a basal cell phenotype, to greater than 0.10 mM, where they express the differentiated phenotype. This process has been associated with a rapid, sustained increase in inos...

journal_title：Journal of cellular physiology

authors： Lee E,Yuspa SH

更新日期：1991-07-01 00:00:00

abstract：:Cigarettes contain various chemicals with the potential to influence metabolic health. Exposure to cigarette smoke causes a dysfunction in pancreatic β-cells and impairs insulin production. However, the mechanisms for cigarette smoke-induced reduction of insulin remain largely unclear. Data from 558 patients with diab...

journal_title：Journal of cellular physiology

authors： Sun Q,Xu H,Xue J,Yang Q,Chen C,Yang P,Han A,Tu Q,Lu J,Gao X,Xiang Q,Liu Q

更新日期：2018-11-01 00:00:00

abstract：:In order to promote cell attachment, fibronectin must first undergo activation by a suitable substrate. In this study, 52 materials have been surveyed for their ability a) to bind fibronectin, b) to activate the cell-adhesive property of fibronectin, and c) to support the growth of cells. Many plastics, polysaccharide...

journal_title：Journal of cellular physiology

authors： Klebe RJ,Bentley KL,Schoen RC

更新日期：1981-12-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) is a pleiotropic cytokine produced by activated macrophages. IL-6 is a multifunctional cytokine that plays a central role in both innate and acquired immune responses. We investigated the signaling pathway involved in IL-6 production stimulated by TNF-alpha in cultured myoblasts...

journal_title：Journal of cellular physiology

authors： Tseng WP,Su CM,Tang CH

更新日期：2010-05-01 00:00:00

abstract：:To analyze transforming growth factor-beta (TGF-beta) response during MCF-7 cell progression, early passage (MCF-7E, < 200 passage) and late passage (MCF-7L, > 500 passage) cells were compared. MCF-7E cells showed an IC50 of approximately 10 ng/ml of TGF-beta1, whereas MCF-7L cells were insensitive. MCF-7E cells conta...

journal_title：Journal of cellular physiology

authors： Ko Y,Banerji SS,Liu Y,Li W,Liang J,Soule HD,Pauley RJ,Willson JK,Zborowska E,Brattain MG

更新日期：1998-08-01 00:00:00

abstract：:Fibroblast growth factors (FGFs) are important regulators of the dynamic development and turnover of tissues. Among FGF receptors, FGFR3 expression is confined in the intestinal crypts. We examined FGFR3-deficient mice and saw increased intestinal crypt depth but no change in villae length or in the distribution of di...

journal_title：Journal of cellular physiology

authors： Arnaud-Dabernat S,Yadav D,Sarvetnick N

更新日期：2008-07-01 00:00:00

abstract：:Recently improved culture conditions for human adult arterial endothelial and smooth muscle cells from a wide variety of donors have been used to study the effects of lipoproteins on proliferation of both cell types in low serum culture medium. Optimal growth of endothelial and smooth muscle cells in an optimal nutrie...

journal_title：Journal of cellular physiology

authors： Chen JK,Hoshi H,McClure DB,McKeehan WL

更新日期：1986-11-01 00:00:00

abstract：:Cell-extracellular matrix interaction plays a major role in maintaining the structural integrity of connective tissues and sensing changes in the biomechanical environment of cells. Collagen VI is a widely expressed non-fibrillar collagen, which regulates tissues homeostasis. The objective of the present investigation...

journal_title：Journal of cellular physiology

authors： Sardone F,Traina F,Tagliavini F,Pellegrini C,Merlini L,Squarzoni S,Santi S,Neri S,Faldini C,Maraldi N,Sabatelli P

更新日期：2014-07-01 00:00:00

abstract：:Wnt/β-catenin signaling pathway plays a crucial role in diabetic cardiomyopathy (DCM), thus we aimed at investigating the effect of one therapeutic approach with resveratrol (RSV) given systemically and combined treatment of RSV with mesenchymal stem cells (MSCs) that was either RSV-preconditioned or not on Wnt/β-cate...

journal_title：Journal of cellular physiology

authors： ShamsEldeen AM,Ashour H,Shoukry HS,Fadel M,Kamar SS,Aabdelbaset M,Rashed LA,Ammar HI

更新日期：2019-07-01 00:00:00

abstract：:Galectins play key roles in the inflammatory cascade. In this study, we aimed to analyze the effect of galectin-1 (Gal-1) in the function of intestinal epithelial cells (IECs) isolated from healthy and inflamed mucosa. IECs isolated from mice or patients with inflammatory bowel diseases (IBD) were incubated with diffe...

journal_title：Journal of cellular physiology

authors： Muglia CI,Gobbi RP,Smaldini P,Delgado ML,Candia M,Zanuzzi C,Sambuelli A,Rocca A,Toscano MA,Rabinovich GA,Docena GH

更新日期：2016-07-01 00:00:00

abstract：:In this study, we compared qualitative and quantitative changes in the lateral mobility of phospholipid molecules in the plasma membrane of intact cells under various conditions of specific interaction of integrins in the cell membrane with two extracellular matrix (ECM) components viz. fibronectin (FN) and laminin (L...

journal_title：Journal of cellular physiology

authors： Ramprasad OG,Rangaraj N,Srinivas G,Thiery JP,Dufour S,Pande G

更新日期：2008-05-01 00:00:00

abstract：:Small intestinal crypt cells play a critical role in modulating Cl- secretion during digestion. The types of Cl- channels mediating Cl- secretion in the small intestine was investigated using the intestinal epithelial cell line, IEC-18, which was derived from rat small intestine crypt cells. In initial radioisotope ef...

journal_title：Journal of cellular physiology

authors： Basavappa S,Vulapalli SR,Zhang H,Yule D,Coon S,Sundaram U

更新日期：2005-01-01 00:00:00

abstract：:The trigger for bone remodeling is bone resorption by osteoclasts. Osteoclast differentiation only occurs on the old bone, which needs to be repaired under physiological conditions. However, uncontrolled bone resorption is often observed in pro-inflammatory bone diseases, such as rheumatoid arthritis. Mature osteoclas...

journal_title：Journal of cellular physiology

authors： Matsuura T,Ichinose S,Akiyama M,Kasahara Y,Tachikawa N,Nakahama KI

更新日期：2017-07-01 00:00:00

abstract：:AMP-activated protein kinase (AMPK) has recently emerged as a potential target for cancer therapy due to the observation that activation of AMPK inhibits tumor cell growth. It is well-known that androgen receptor (AR) signaling is a major driver for the development and progression of prostate cancer and that downregul...

journal_title：Journal of cellular physiology

authors： Shen M,Zhang Z,Ratnam M,Dou QP

更新日期：2014-06-01 00:00:00

abstract：:The ubiquitous α-catulin acts as a scaffold for distinct signalosomes including RhoA/ROCK; however, its function is not well understood. While α-catulin has homology to the cytoskeletal linkers α-catenin and vinculin, it appears to be functionally divergent. Here we further investigated α-catulin function in pulmonary...

journal_title：Journal of cellular physiology

authors： Bear MD,Liu T,Abualkhair S,Ghamloush MA,Hill NS,Preston I,Fanburg BL,Kayyali US,Toksoz D

更新日期：2016-04-01 00:00:00

abstract：:Arginine vasopressin (AVP) regulates glomerular hemodynamics, alters extracellular matrix production, and induces proliferation of glomerular mesangial cells (MCs). Therefore, AVP may play a role in glomerular sclerosis and the progression of chronic renal failure. To investigate changes in early gene expression which...

journal_title：Journal of cellular physiology

authors： Rupprecht HD,Sukhatme VP,Rupprecht AP,Sterzel RB,Coleman DL

更新日期：1994-05-01 00:00:00

abstract：:Addition of bombesin in the presence of either forskolin or cholera toxin caused a marked (4-6 fold) enhancement of cAMP accumulation in Swiss 3T3 cells. This effect was time and concentration dependent, induced by various bombesin-like peptides and blocked by a bombesin antagonist. Enhancement of cAMP accumulation by...

journal_title：Journal of cellular physiology

authors： Millar JB,Rozengurt E

更新日期：1988-11-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is prevalent chronic liver diseases with unknown mechanism and no curative treatment. Hepatokines have demonstrated importance in NAFLD but, role of selenoprotein P (SeP) in NAFLD is unknown. A total of 79 patients with NAFLD and 79 healthy controls were included in this case-c...

journal_title：Journal of cellular physiology

authors： Chen Y,He X,Chen X,Li Y,Ke Y

更新日期：2020-10-22 00:00:00

abstract：:To test the hypothesis that football training would be accompanied by physiological adaptations and hormonal changes, we analyzed the effects of a whole football season on physical fitness and hormonal concentrations in youth football players. Male football players (n = 29, age 16.51 ± 0.7 years) in a regional profess...

journal_title：Journal of cellular physiology

authors： Muscella A,Vetrugno C,Spedicato M,Stefàno E,Marsigliante S

更新日期：2019-11-01 00:00:00

abstract：:When 3T6 cells undergo a serum-induced transition from resting to growing state, the number of ribosomes and the amounts of mRNA increase as the cells prepare for DNA synthesis. We have examined the effect of preventing ribosome synthesis during this transition. When resting cells are stimulated to grow in the presenc...

journal_title：Journal of cellular physiology

authors： Johnson LF,Penman S,Green H

更新日期：1975-12-01 00:00:00

abstract：:The in vitro culture of porcine bone marrow-derived mesenchymal stem cells (MSCs) was used for the investigation of adult stem cell biology. Isolated porcine MSCs possessed the ability to proliferate extensively in an antioxidants-rich medium containing 5% fetal bovine serum (FBS). Greater than 40 serial MSC passages ...

journal_title：Journal of cellular physiology

authors： Vacanti V,Kong E,Suzuki G,Sato K,Canty JM,Lee T

更新日期：2005-11-01 00:00:00