The interplay of AMP-activated protein kinase and androgen receptor in prostate cancer cells.

abstract：:Methionine dependence is a metabolic defect found thus far only in transformed and malignant cells. The defect is manifested as the inability of cells to grow in media in which methionine (Met) is replaced by its immediate precursor homocysteine (Hcy). We have termed this Met- Hcy+ media. We demonstrate here that meth...

journal_title：Journal of cellular physiology

authors： Stern PH,Wallace CD,Hoffman RM

更新日期：1984-04-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) signaling in endothelial cells is able to modulate angiogenesis and vascular remodeling, although the underlying molecular mechanisms remain poorly understood. Endoglin and ALK-1 are components of the TGF-beta receptor complex, predominantly expressed in endothelial cells, an...

journal_title：Journal of cellular physiology

authors： Blanco FJ,Santibanez JF,Guerrero-Esteo M,Langa C,Vary CP,Bernabeu C

更新日期：2005-08-01 00:00:00

abstract：:Optical indicators of the cationic, cyanine and anionic oxonol classes were used to evaluate the plasma membrane potential of animal cells in suspension and in monolayer culture. The optical signals were calibrated by using diffusion potentials either of K+ (in the presence of valinomycin) or of H+ (in the presence of...

journal_title：Journal of cellular physiology

authors： Bashford CL,Alder GM,Gray MA,Micklem KJ,Taylor CC,Turek PJ,Pasternak CA

更新日期：1985-06-01 00:00:00

abstract：:Core binding factor β (Cbfβ) is a partner protein of Runx family transcription factors with minimally characterized function in cartilage. Here we address the role of Cbfβ in cartilage by generating chondrocyte-specific Cbfβ-deficient mice (Cbfb(Δch/Δch) ) from Cbfb-floxed mice crossed with mice expressing Cre from th...

journal_title：Journal of cellular physiology

authors： Park NR,Lim KE,Han MS,Che X,Park CY,Kim JE,Taniuchi I,Bae SC,Choi JY

更新日期：2016-01-01 00:00:00

abstract：:Subcellular organellles from livers of rats three days prenatal to 50 weeks postnatal were separated on sucrose gradients. The peroxisomes had a constant density of 1.243 g/ml throughout the life of the animal. The density of the mitochondria changed from about 1.236 g/ml at birth to a constant value of 1.200 g/ml aft...

journal_title：Journal of cellular physiology

authors： Krahling JB,Gee R,Gauger JA,Tolbert NE

更新日期：1979-12-01 00:00:00

abstract：:Differentiated embryo chondrocyte 1 (DEC1), a member of basic-helix-loop-helix transcription factor Bhlhe40, also called stimulated by retinoic acid 13, STRA13, plays an important role in the regulation of adipogenesis, tumorigenesis, peripheral circadian output, response to hypoxia, and development of metabolic syndr...

journal_title：Journal of cellular physiology

authors： Huang Y,Lai X,Hu L,Lei C,Lan X,Zhang C,Ma Y,Zheng L,Bai YY,Lin F,Chen H

更新日期：2018-12-01 00:00:00

abstract：:Dermal fibroblasts exposed to low oxygen tension show upregulated synthesis of transforming growth factor-beta 1 (TGF-beta 1), an established stimulatory peptide in the formation of extracellular matrix proteins. In this report, procollagen synthesis was measured in cultures of confluent adult human dermal fibroblasts...

journal_title：Journal of cellular physiology

authors： Falanga V,Martin TA,Takagi H,Kirsner RS,Helfman T,Pardes J,Ochoa MS

更新日期：1993-11-01 00:00:00

abstract：:The extent to which autolytic microbial enzymes are involved in the fate of microorganisms ingested by phagocytes has not been determined. It is known, however, that activation of degradative enzymes occurs during certain microbicidal events. We examined the possible role of the pneumococcal autolytic enzyme (an N-ace...

journal_title：Journal of cellular physiology

authors： Tomasz A,Beckerdite S,McDonnell M,Elsbach P

更新日期：1977-08-01 00:00:00

abstract：:Epidermal growth factor-like domain-containing protein 7 (EGFL7), a member of the epidermal growth factor (EGF)-like protein family, is a potent angiogenic factor expressed in many different cell types. EGFL7 plays a vital role in controlling vascular angiogenesis during embryogenesis, organogenesis, and maintaining s...

journal_title：Journal of cellular physiology

authors： Hong G,Kuek V,Shi J,Zhou L,Han X,He W,Tickner J,Qiu H,Wei Q,Xu J

更新日期：2018-11-01 00:00:00

abstract：:Human neutrophils labeled with chlortetracycline (CTC), commonly used as a probe of membrane-bound calcium, release lysosomal enzymes and exhibit a rapid decrease in fluorescence when exposed to the chemotactic peptide fMet-Leu-Phe or the lectin Con A. This decrease has been attributed to the release of calcium from a...

journal_title：Journal of cellular physiology

authors： Smolen JE,Noble P,Freed R,Weissmann G

更新日期：1983-12-01 00:00:00

abstract：:Cardiac fibroblast (CF) differentiation to myofibroblasts expressing α-smooth muscle actin (α-SMA) plays a key role in cardiac fibrosis. Therefore, a study of the mechanism regulating α-SMA expression is a means to understanding the mechanism of fibroblast differentiation and cardiac fibrosis. Previous studies have sh...

journal_title：Journal of cellular physiology

authors： He Y,Ling S,Sun Y,Sheng Z,Chen Z,Pan X,Ma G

更新日期：2019-05-01 00:00:00

abstract：:Osteoporosis can result from intestinal inflammation, as is seen with inflammatory bowel disease. Probiotics, microorganisms that provide a health benefit to the host when ingested in adequate amounts, can have anti-inflammatory properties and are currently being examined to treat inflammatory bowel disease. Here, we ...

journal_title：Journal of cellular physiology

authors： McCabe LR,Irwin R,Schaefer L,Britton RA

更新日期：2013-08-01 00:00:00

abstract：:Addition of bombesin in the presence of either forskolin or cholera toxin caused a marked (4-6 fold) enhancement of cAMP accumulation in Swiss 3T3 cells. This effect was time and concentration dependent, induced by various bombesin-like peptides and blocked by a bombesin antagonist. Enhancement of cAMP accumulation by...

journal_title：Journal of cellular physiology

authors： Millar JB,Rozengurt E

更新日期：1988-11-01 00:00:00

abstract：:Tumor cells secrete extracellular vesicles (EVs) for intercellular communication. EVs by transporting different proteins, nucleic acids, and lipids contribute to affect target cell function and fate. ‎EVs which originate directly from multivesicular bodies so-called exosomes have dramatically fascinated the attention ...

journal_title：Journal of cellular physiology

authors： Jabbari N,Akbariazar E,Feqhhi M,Rahbarghazi R,Rezaie J

更新日期：2020-10-01 00:00:00

abstract：:A method, based on the differing capacities of cells to adhere to a column of polyester fibres, has been described for separating human bone marrow cells into a nonadherent and an adherent fraction. The effect of this cell separation procedure on colony formation by erythroid progenitor cells was investigated. In cont...

journal_title：Journal of cellular physiology

authors： Aye MT

更新日期：1977-04-01 00:00:00

abstract：:Obesity predisposes to glucose intolerance and type 2 diabetes (T2D). This disease is often characterized by insulin resistance, changes in insulin clearance, and β-cell dysfunction. However, studies indicate that, for T2D development, disruptions in glucagon physiology also occur. Herein, we investigated the involvem...

journal_title：Journal of cellular physiology

authors： Araujo TR,da Silva JA,Vettorazzi JF,Freitas IN,Lubaczeuski C,Magalhães EA,Silva JN,Ribeiro ES,Boschero AC,Carneiro EM,Bonfleur ML,Ribeiro RA

更新日期：2019-05-01 00:00:00

abstract：:Incubation of primary cultures of parenchymal hepatocytes in a conditioned medium (CM), collected over the first 3 h of serum-free rat hepatocyte culture (CM(0-3)), induces a time dependent increase of the frequency of apoptotic cells which is accompanied by prominent changes of cell morphology. Short-term treatment w...

journal_title：Journal of cellular physiology

authors： Bresgen N,Rolinek R,Hochleitner E,Lottspeich F,Eckl PM

更新日期：2004-03-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor-γ coactivator-1 deficient (Pgc-1β-/- ) murine hearts model the increased, age-dependent, ventricular arrhythmic risks attributed to clinical conditions associated with mitochondrial energetic dysfunction. These were accompanied by compromised action potential (AP) upstroke ra...

journal_title：Journal of cellular physiology

authors： Ahmad S,Valli H,Smyth R,Jiang AY,Jeevaratnam K,Matthews HR,Huang CL

更新日期：2019-04-01 00:00:00

abstract：:Selective spermatozoa movement from storage of the oviduct to fertilization site is suggested to be a result of chemotaxis. In the present study, Natriuretic peptide precursor A (NPPA) induced sperm chemotaxis in capillaries and enhanced intracellular Ca(2+) level, both of which could be blocked by the Natriuretic Pep...

journal_title：Journal of cellular physiology

authors： Bian F,Mao G,Guo M,Mao G,Wang J,Li J,Han Y,Chen X,Zhang M,Xia G

更新日期：2012-05-01 00:00:00

abstract：:Human population is facing a revolutionary change in the demographic structure with an increasing number of elderly people requiring an unmet need to ensure a smooth aging process and dental care is certainly an important aspect that has to be considered. To date, dentistry has been conservative and the need of transf...

journal_title：Journal of cellular physiology

authors： Monti M,Graziano A,Rizzo S,Perotti C,Del Fante C,d'Aquino R,Redi CA,Rodriguez Y Baena R

更新日期：2017-03-01 00:00:00

abstract：:The temperature-sensitive (ts) Chinese hamster ovary (CHO) cell mutant tsH1 contains a thermolabile leucyl-tRNA synthetase. Upon incubation at the nonpermissive temperature of 39.5 degrees C, the enzyme became reversibly inhibited over a period of minutes, and the cells lost viability over a period of many hours. Howe...

journal_title：Journal of cellular physiology

authors： Vidair CA,Dewey WC

更新日期：1989-08-01 00:00:00

abstract：:Phenotypically different osteoclasts may be generated from different subsets of precursors. To what extent the formation of these osteoclasts is influenced or mediated by the inflammatory cytokine TNF-α, is unknown and was investigated in this study. The osteoclast precursors early blasts (CD31hi Ly-6C- ), myeloid bla...

journal_title：Journal of cellular physiology

authors： Cao Y,Jansen IDC,Sprangers S,de Vries TJ,Everts V

更新日期：2017-12-01 00:00:00

abstract：:A neuroblastoma cell line was assessed for its capacity to bind tetanus toxin (TT) by using immunofluorescence and flow cytometry to analyze cells on a single cell basis. A clone of Neuro 2a, N2AB-1, was shown to bind variable amounts of TT per cell and this binding could be saturated by increasing doses of the toxin....

journal_title：Journal of cellular physiology

authors： Notter MF,Leary JF

更新日期：1985-12-01 00:00:00

abstract：:A variant of the hypoxanthine-guanine phosphoribosyltransferase deficient, and adenine phosphoribosyltransferase deficient mouse resistant to 6-azauridine. These cells are not only resistant to 6-azauridine (5 X 10(-4) M), but also to adenosine (10(-3) M). Resistance persists indefinitely even in the absence of both c...

journal_title：Journal of cellular physiology

authors： Hashmi S,May SR,Krooth RS,Miller OJ

更新日期：1975-10-01 00:00:00

abstract：:Repetitive mechanical stimulation of cultured avian skeletal muscle increases the synthesis of prostaglandins (PG) E2 and F2 alpha which regulate protein turnover rates and muscle cell growth. These stretch-induced PG increases are reduced in low extracellular calcium medium and by specific phospholipase inhibitors. M...

journal_title：Journal of cellular physiology

authors： Vandenburgh HH,Shansky J,Karlisch P,Solerssi RL

更新日期：1993-04-01 00:00:00

abstract：:We have shown in the present study and in studies reported previously that preneoplastic and neoplastic rat tracheal epithelial (RTE) cell lines express TGF alpha and do so regardless of the mechanism by which they were transformed. In order to determine whether TGF alpha is an autocrine growth regulator of immortaliz...

journal_title：Journal of cellular physiology

authors： Ferriola PC,Earp HS,Di Augustine R,Nettesheim P

更新日期：1991-04-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer death worldwide. Although diagnostic methods and targeted drugs have been rapidly developed in recent years, the underlying molecular mechanisms in the pathogenesis of lung cancer remain enigmatic. The N6-methyladenosine (m6 A) modification is the most common modification of ...

journal_title：Journal of cellular physiology

authors： Xu R,Pang G,Zhao Q,Yang L,Chen S,Jiang L,Shen Y,Shao W

更新日期：2020-11-01 00:00:00

abstract：:Primary astroglial cultures were used to compare the relationships to cell cycling of dolichol-linked glycoprotein synthesis, and of availability of mevalonate, the precursor of dolichol and other isoprenoid lipids. With shift-up to 10% serum (time 0) after 48 h of serum depletion, the proportion of cells in S phase (...

journal_title：Journal of cellular physiology

authors： Langan TJ,Slater MC

更新日期：1991-11-01 00:00:00

abstract：:Normal rat kidney [NRK] cells grown in the presence of epidermal growth factor (EGF) or platelet-derived growth factor (PDGF) have a normal phenotype and undergo density-dependent growth inhibition, whereas in the presence of multiple growth factors, density arrest is lost and the cells become phenotypically transform...

journal_title：Journal of cellular physiology

authors： Rijksen G,Völler MC,Van Zoelen EJ

更新日期：1993-02-01 00:00:00

abstract：:HCF-1 functions as a coactivator for herpes simplex virus VP16 and a number of mammalian transcription factors. Mature HCF-1 is composed of two subunits generated by proteolytic cleavage of a larger precursor at six centrally-located HCF(PRO) repeats. The resulting N- and C-terminal subunits remain tightly associated ...

journal_title：Journal of cellular physiology

authors： Mahajan SS,Johnson KM,Wilson AC

更新日期：2003-02-01 00:00:00