Abstract:
:A variant of the hypoxanthine-guanine phosphoribosyltransferase deficient, and adenine phosphoribosyltransferase deficient mouse resistant to 6-azauridine. These cells are not only resistant to 6-azauridine (5 X 10(-4) M), but also to adenosine (10(-3) M). Resistance persists indefinitely even in the absence of both compounds. The resistant cells are killed by 5-fluorouridine (10(-6) M), indicating that the part of the salvage pathway for pyrimidine ribonucleotide biosynthesis which is relevant to the action of 6-azauridine is intact. The heritable change producing concurrent resistance to 6-azauridine and adenosine probably involves the de novo pyrimidine biosynthetic pathway.
journal_name
J Cell Physioljournal_title
Journal of cellular physiologyauthors
Hashmi S,May SR,Krooth RS,Miller OJdoi
10.1002/jcp.1040860202keywords:
subject
Has Abstractpub_date
1975-10-01 00:00:00pages
191-200issue
2 Pt 1eissn
0021-9541issn
1097-4652journal_volume
86pub_type
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