Abstract:
:Colorectal cancer is the fourth most common neoplasia in Europe, where it accounts for 28.2 new cases per 100,000 inhabitants. In an effort to decrease the incidence of this disease, various prevention measures are being studied, one of which are anthocyanin-rich foods. Anthocyanins are potent antioxidant flavonoids mainly found in flowers and colorful fruits and vegetables. These nutraceuticals have diverse biological functions once ingested, including immunomodulatory, anti-inflammatory and antitumor functions. In order to test the preventive effect of these flavonoids against colorectal cancer, an animal model (Rattus norvegicus F344) was developed. In this model two doses of azoxymethane (10 mg/kg) and two treatments with dextran sodium sulfate (DSS) were administered to the animals. For 20 weeks they were fed either control rat feed, control sausages, or functional sausages containing 0.1% (w/w) of anthocyanins from a mixture of dehydrated blackberries and strawberries. At the end of that period, the animals were sacrificed and their antioxidant plasma levels and digestive tract tissues were analyzed. The results revealed a statistically significant reduction in the number of colon tumors in the functional sausages cohort with respect to the control animals and an increase in the FRAP (ferric reducing ability of plasma) total antioxidant activity in that same cohort. Colon microbiota differences were also examined via metagenomics 16S ribosomal RNA (rRNA) sequencing, revealing a significant reduction in populations of the pro-inflammatory Bilophila wadsworthia. Therefore, the design of functional processed meat products, such as ones enriched with anthocyanins, may be an effective strategy for preventing inflammatory digestive diseases and colorectal cancer in human populations.
journal_name
Genes (Basel)journal_title
Genesauthors
Fernández J,García L,Monte J,Villar CJ,Lombó Fdoi
10.3390/genes9030133subject
Has Abstractpub_date
2018-03-01 00:00:00issue
3issn
2073-4425pii
genes9030133journal_volume
9pub_type
杂志文章相关文献
Genes文献大全abstract::Leafminer insects of the genus Liriomyza are small flies whose larvae feed on the internal tissue of some of the most important crop plants for the human diet. Several of these pest species are highly uniform from the morphological point of view, meaning molecular data represents the only reliable taxonomic tool usefu...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9110554
更新日期:2018-11-15 00:00:00
abstract::The anaerobic degradation of benzoate in bacteria involves the benzoyl-CoA central pathway. Azoarcus/Aromatoleum strains are a major group of anaerobic benzoate degraders, and the transcriptional regulation of the bzd genes was extensively studied in Azoarcus sp. CIB. In this work, we show that the bzdR regulatory gen...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10070489
更新日期:2019-06-27 00:00:00
abstract::Sex chromosomes form once recombination is halted around the sex-determining locus between a homologous pair of chromosomes, resulting in a male-limited Y chromosome. We recently characterized the nascent sex chromosome system in the Trinidadian guppy (Poeciliareticulata). The guppy Y is one of the youngest animal sex...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9050238
更新日期:2018-05-03 00:00:00
abstract::Unbalanced dietary habits and gut dysmotility are causative factors in metabolic and functional gut disorders, including obesity, diabetes, and constipation. Reduction in luminal butyrate synthesis is known to be associated with gut dysbioses, and studies have suggested that restoring butyrate formation in the colon m...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8120350
更新日期:2017-11-28 00:00:00
abstract::The transcription factor PAX6 is essential in ocular development in vertebrates, being considered the master regulator of the eye. During eye development, it is essential for the correct patterning and formation of the multi-layered optic cup and it is involved in the developing lens and corneal epithelium. In adultho...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes10121050
更新日期:2019-12-17 00:00:00
abstract::Ferns are a representative clade in plant evolution although underestimated in the genomic era. Ceratopteris richardii is an emergent model for developmental processes in ferns, yet a complete scheme of the different growth stages is necessary. Here, we present a developmental analysis, at the tissue and cellular leve...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11121455
更新日期:2020-12-04 00:00:00
abstract::Root nodule symbioses (nodulation) and whole genome duplication (WGD, polyploidy) are both important phenomena in the legume family (Leguminosae). Recently, it has been proposed that polyploidy may have played a critical role in the origin or refinement of nodulation. However, while nodulation and polyploidy have been...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8120357
更新日期:2017-11-30 00:00:00
abstract::This article explores the mechanism of miR-194 on the proliferation and apoptosis of Aβ1-42-transduced hippocampal neurons. Aβ1-42-transduced hippocampal neuron model was established by inducing hippocampal neurons with Aβ1-42. MTT assay and flow cytometry were used to detect the viability and apoptosis of hippocampal...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10040313
更新日期:2019-04-21 00:00:00
abstract::White spot syndrome virus (WSSV), the lone virus of the genus Whispovirus under the family Nimaviridae, is one of the most devastating viruses affecting the shrimp farming industry. Knowledge about this virus, in particular, its evolution history, has been limited, partly due to its large genome and the lack of other ...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11010094
更新日期:2020-01-14 00:00:00
abstract::The increasing availability of large-scale time series data allows the inference of microbial community dynamics by association network analysis. However, correlation-based association network analyses are noninformative of causal, mediating and time-dependent relationships between microbial community functional facto...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes10030216
更新日期:2019-03-14 00:00:00
abstract::microRNA (miRNA) activity and regulation are of increasing interest as new therapeutic targets. Traditional approaches to assess miRNA levels in cells rely on RNA sequencing or quantitative PCR. While useful, these approaches are based on RNA extraction and cannot be applied in real-time to observe miRNA activity with...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9060305
更新日期:2018-06-19 00:00:00
abstract::Changes of telomere length with age were assessed in diploid and triploid rainbow trout (Oncorhynchus mykiss) females in the cross-sectional study using Q-FISH technique. Triploid trout as sterile do not invest an energy in gametogenesis and continue to grow, whereas fertile diploid individuals suffer from declines in...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11070786
更新日期:2020-07-13 00:00:00
abstract::This study investigated the effects of dietary terrestrial animal and plant proteins on the intestinal transcriptomes of yellowtail kingfish (YTK), Seriola lalandi, an ecologically and economically important marine species in Australia. Five diets containing fish meal (FM), poultry by-product meal (PBM), blood meal (B...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11060621
更新日期:2020-06-05 00:00:00
abstract::The Muraenidae is one of the largest and most complex anguilliform families. Despite their abundance and important ecological roles, morays are little studied, especially cytogenetically, and both their phylogenetic relationships and the taxonomy of their genera are controversial. With the aim of extending the karyolo...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11111319
更新日期:2020-11-06 00:00:00
abstract::Keratin-associated proteins (KAPs) are structural components of wool and hair fibers. To date, eight high glycine/tyrosine KAP (HGT-KAP) families have been identified in humans, but only three have been identified in sheep. In this study, the putative ovine homolog of the human KAP22-1 gene (KRTAP22-1) was amplified u...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8010027
更新日期:2017-01-11 00:00:00
abstract::Cancer genome sequence data provide an invaluable resource for inferring the key mechanisms by which mutations arise in cancer cells, favoring their survival, proliferation and invasiveness. Here we examine recent advances in understanding the molecular mechanisms responsible for the predominant type of genetic altera...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes5010108
更新日期:2014-03-05 00:00:00
abstract::Death investigations often include an effort to establish the postmortem interval (PMI) in cases in which the time of death is uncertain. The postmortem interval can lead to the identification of the deceased and the validation of witness statements and suspect alibis. Recent research has demonstrated that microbes pr...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9020104
更新日期:2018-02-16 00:00:00
abstract::Small RNAs play an important role in regulating plant responses to abiotic stress. Depending on the method of salt application, whether sudden or gradual, plants may experience either salt shock or salt stress, respectively. In this study, small RNA expression in response to salt shock and long-term salt stress in par...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8120369
更新日期:2017-12-05 00:00:00
abstract::Approximately 150 fungal species are considered as primary pathogens of humans and animals[...]. ...
journal_title:Genes
pub_type: 社论
doi:10.3390/genes10020136
更新日期:2019-02-12 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. An ALS drug, Riluzole, has been shown to induce two different anticancer effects on hepatocellular carcinoma (HCC). In light of this finding, we explore the relationship between ALS and cancer, especially for HCC, from the molecular biological v...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8100243
更新日期:2017-09-27 00:00:00
abstract::Intercellular karyotypic variability has been a focus of genetic research for more than 50 years. It has been repeatedly shown that chromosome heterogeneity manifesting as chromosomal mosaicism is associated with a variety of human diseases. Due to the ability of changing dynamically throughout the ontogeny, chromosom...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes10050379
更新日期:2019-05-19 00:00:00
abstract::Legumes and actinorhizal plants are capable of forming root nodules symbiosis with rhizobia and Frankia bacteria. All these nodulating species belong to the nitrogen fixation clade. Most likely, nodulation evolved once in the last common ancestor of this clade. NIN (NODULE INCEPTION) is a transcription factor that is ...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes11070777
更新日期:2020-07-11 00:00:00
abstract::In genome analysis, k-mer-based comparison methods have become standard tools. However, even though they are able to deliver reliable results, other algorithms seem to work better in some cases. To improve k-mer-based DNA sequence analysis and comparison, we successfully checked whether adding positional resolution is...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes8040122
更新日期:2017-04-19 00:00:00
abstract::While the clinical benefit of proteasome inhibitors (PIs) for multiple myeloma (MM) treatment remains unchallenged, dose-limiting toxicities and the inevitable emergence of drug resistance limit their long-term utility. Disease eradication is compromised by drug resistance that is either present de novo or therapy-ind...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes7100084
更新日期:2016-10-06 00:00:00
abstract::During vertebrate embryogenesis, precise regulation of gene expression is crucial for proper cell fate determination. Much of what we know about vertebrate development has been gleaned from experiments performed on embryos of the amphibian Xenopus laevis; this review will focus primarily on studies of this model organ...
journal_title:Genes
pub_type: 杂志文章,评审
doi:10.3390/genes10110895
更新日期:2019-11-06 00:00:00
abstract::The grizzly bear (Ursus arctos ssp. horribilis) represents the largest population of brown bears in North America. Its genome was sequenced using a microfluidic partitioning library construction technique, and these data were supplemented with sequencing from a nanopore-based long read platform. The final assembly was...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes9120598
更新日期:2018-11-30 00:00:00
abstract::Helicobacter pylori (H. pylori) is one of the main causes of gastric gancer. TNF-related apoptosis-inducing ligand (TRAIL) is a protein able to promote apoptosis in cancer cells, however not in gastric cancer, which presents resistance to apoptosis via TRAIL. It is believed that MicroRNA-106b-5p might be involved in t...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11040393
更新日期:2020-04-05 00:00:00
abstract::Inositol trisphosphate receptor (IP3R) mediated Ca+2 signaling is essential in determining the cell fate by regulating numerous cellular processes, including cell division and cell death. Despite extensive studies about the characterization of IP3R in cancer, the underlying molecular mechanism initiating the cell prol...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes12010034
更新日期:2020-12-29 00:00:00
abstract::Aminoacyl-tRNA synthetases (aaRSs) are key enzymes in the mRNA translation machinery, yet they possess numerous non-canonical functions developed during the evolution of complex organisms. The aaRSs and aaRS-interacting multi-functional proteins (AIMPs) are continually being implicated in tumorigenesis, but these conn...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11111384
更新日期:2020-11-22 00:00:00
abstract::We report the underlying genetic causes of prelingual hearing loss (HL) segregating in eight large consanguineous families, ascertained from the Punjab province of Pakistan. Exome sequencing followed by segregation analysis revealed seven potentially pathogenic variants, including four novel alleles c.257G>A, c.6083A>...
journal_title:Genes
pub_type: 杂志文章
doi:10.3390/genes11090978
更新日期:2020-08-22 00:00:00