Abstract：
:Aminoacyl-tRNA synthetases (aaRSs) are key enzymes in the mRNA translation machinery, yet they possess numerous non-canonical functions developed during the evolution of complex organisms. The aaRSs and aaRS-interacting multi-functional proteins (AIMPs) are continually being implicated in tumorigenesis, but these connections are often limited in scope, focusing on specific aaRSs in distinct cancer subtypes. Here, we analyze publicly available genomic and transcriptomic data on human cytoplasmic and mitochondrial aaRSs across many cancer types. As high-throughput technologies have improved exponentially, large-scale projects have systematically quantified genetic alteration and expression from thousands of cancer patient samples. One such project is the Cancer Genome Atlas (TCGA), which processed over 20,000 primary cancer and matched normal samples from 33 cancer types. The wealth of knowledge provided from this undertaking has streamlined the identification of cancer drivers and suppressors. We examined aaRS expression data produced by the TCGA project and combined this with patient survival data to recognize trends in aaRSs' impact on cancer both molecularly and prognostically. We further compared these trends to an established tumor suppressor and a proto-oncogene. We observed apparent upregulation of many tRNA synthetase genes with aggressive cancer types, yet, at the individual gene level, some aaRSs resemble a tumor suppressor while others show similarities to an oncogene. This study provides an unbiased, overarching perspective on the relationship of aaRSs with cancers and identifies certain aaRS family members as promising therapeutic targets or potential leads for developing biological therapy for cancer.
journal_name
Genes (Basel)journal_title
Genesauthors
Wang J,Vallee I,Dutta A,Wang Y,Mo Z,Liu Z,Cui H,Su AI,Yang XLdoi
10.3390/genes11111384subject
Has Abstractpub_date
2020-11-22 00:00:00issue
11issn
2073-4425pii
genes11111384journal_volume
11pub_type
杂志文章相关文献
Genes文献大全abstract：:We set out to assess the NIH/3T3 cell proliferation activity of Arabidopsis oil body-expressed recombinant oleosin-hEGF-hEGF protein. Normally, human epidermal growth factor (hEGF) is purified through complex process, however, oleosin fusion technology provides an inexpensive and scalable platform for its purification...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11090959
更新日期：2020-08-19 00:00:00
abstract：:One of the hallmarks of cancer cells is their indefinite replicative potential, made possible by the activation of a telomere maintenance mechanism (TMM). The majority of cancers reactivate the reverse transcriptase, telomerase, to maintain their telomere length but a minority (10% to 15%) utilize an alternative lengt...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes11020133
更新日期：2020-01-27 00:00:00
abstract：:In cystic fibrosis (CF), mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene disrupt the capacity of the encoded protein to function as a channel to transport chloride ions and water across cell membranes. The consequences are deleterious, system-wide, and immensely variable, even among pa...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes10030180
更新日期：2019-02-26 00:00:00
abstract：:The endometrium undergoes a series of complex changes to form a receptive endometrium (RE) that allows the embryo to be implanted. The inability to establish endometrial receptivity of livestock causes embryo implantation failure and considerable losses to animal husbandry. MicroRNAs (miRNAs) are a class of noncoding ...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11091052
更新日期：2020-09-07 00:00:00
abstract：:The histone-like nucleoid structuring protein (H-NS) has played a key role in shaping the evolution of Shigella spp., and provides the backdrop to the regulatory cascade that controls virulence by silencing many genes found on the large virulence plasmid. H-NS and its paralogue StpA are present in all four Shigella sp...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes7120112
更新日期：2016-12-01 00:00:00
abstract：:A major technological shift in the research community in the past decade has been the adoption of high throughput (HT) technologies to interrogate the genome, epigenome, transcriptome, and proteome in a massively parallel fashion [...]. ...
journal_title：Genes
pub_type： 社论
doi：10.3390/genes11030245
更新日期：2020-02-26 00:00:00
abstract：:The contribution of chromatin dynamics to the regulation of human disease-associated loci such as the cystic fibrosis transmembrane conductance regulator (CFTR) gene has been the focus of intensive experimentation for many years. Recent technological advances in the analysis of transcriptional mechanisms across the en...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes6030543
更新日期：2015-07-13 00:00:00
abstract：:The integration of phenotypes and genotypes is at an unprecedented level and offers new opportunities to establish deep phenotypes. There are a number of challenges to overcome, specifically, accelerated growth of data, data silos, incompleteness, inaccuracies, and heterogeneity within and across data sources. This pe...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10010018
更新日期：2018-12-28 00:00:00
abstract：:Neurofibromatosis type 1 (NF1) is a cancer predisposition syndrome that results from dominant loss-of-function mutations mainly in the NF1 gene. Large rearrangements are present in 5-10% of affected patients, generally encompass NF1 neighboring genes, and are correlated with a more severe NF1 phenotype. Evident genoty...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10110839
更新日期：2019-10-24 00:00:00
abstract：:Post-translational modification (PTM) is a critical biological reaction which adds to the diversification of the proteome. With numerous known modifications being studied, pupylation has gained focus in the scientific community due to its significant role in regulating biological processes. The traditional experimenta...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11121431
更新日期：2020-11-28 00:00:00
abstract：:Small and isolated populations are subject to the loss of genetic variation as a consequence of inbreeding and genetic drift, which in turn, can affect the fitness and long-term viability of populations. Translocations can be used as an effective conservation tool to combat this loss of genetic diversity through estab...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10110851
更新日期：2019-10-28 00:00:00
abstract：:Prader-Willi syndrome (PWS) is a complex multisystemic condition caused by a lack of paternal expression of imprinted genes from the 15q11.2-q13 region. Limited literature exists on the association between molecular classes, growth hormone use, and the prevalence of psychiatric phenotypes in PWS. In this study, we ana...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11111250
更新日期：2020-10-23 00:00:00
abstract：:Oral clefts are composed of cleft of the lip, cleft of the lip and palate, or cleft of the palate, and they are associated with a wide range of expression and severity. When cleft of the palate is associated with cleft of the lip with preservation of the primary palate, it defines an atypical phenotype called disconti...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10100833
更新日期：2019-10-22 00:00:00
abstract：:MicroRNAs (miRNAs) are short, single-stranded, non-coding RNA molecules that act as post-transcriptional gene regulators. They can inhibit target protein-coding genes, through repressing messenger RNA (mRNA) translation or promoting their degradation. miRNAs were initially found to be originated from nuclear genome an...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes5040865
更新日期：2014-09-26 00:00:00
abstract：:Yersinia enterocolitica is the causative agent of yersiniosis, a zoonotic disease of growing epidemiological importance with significant consequences for public health. This pathogenic species has been intensively studied for many years. Six biotypes (1A, 1B, 2, 3, 4, 5) and more than 70 serotypes of Y. enterocolitica...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes9050235
更新日期：2018-05-03 00:00:00
abstract：:This review looks back at five decades of research into genetic susceptibility to colorectal cancer (CRC) and the insights these studies have provided. Initial evidence of a genetic basis of CRC stems from epidemiological studies in the 1950s and is further provided by the existence of multiple dominant predisposition...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes5020270
更新日期：2014-03-27 00:00:00
abstract：:The sea lamprey (Petromyzon marinus) is one of few vertebrate species known to reproducibly eliminate large fractions of its genome during normal embryonic development. This germline-specific DNA is lost in the form of large fragments, including entire chromosomes, and available evidence suggests that DNA elimination ...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10100832
更新日期：2019-10-22 00:00:00
abstract：:DNA methylation, catalyzed by DNA methyltransferases (DNMTs), is an epigenetic mark that needs to be faithfully replicated during mitosis in order to maintain cell phenotype during successive cell divisions. This epigenetic mark is located on the 5'-carbon of the cytosine mainly within cytosine⁻phosphate⁻guanine (CpG)...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes10010065
更新日期：2019-01-18 00:00:00
abstract：:Gruiformes is a group with phylogenetic issues. Recent studies based on mitochondrial and genomic DNA have proposed the existence of a core Gruiformes, consisting of five families: Heliornithidae, Aramidae, Gruidae, Psophiidae and Rallidae. Karyotype studies on these species are still scarce, either by conventional st...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11030307
更新日期：2020-03-13 00:00:00
abstract：:Alterations in the tumor suppressor phosphatase and tensin homolog (PTEN) occur in a substantial proportion of solid tumors. These events drive tumorigenesis and tumor progression. Given its central role as a downregulator of the phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway, PTEN i...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes11070719
更新日期：2020-06-28 00:00:00
abstract：:The heavy impact of obesity on both the population general health and the economy makes clarifying the underlying mechanisms, identifying pharmacological targets, and developing efficient therapies for obesity of high importance. The main struggle facing obesity research is that the underlying mechanistic pathways are...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes11080875
更新日期：2020-07-31 00:00:00
abstract：:The large phenotypic variation in the olfactory bulb may be related to heterogeneity in the progenitor cells. Accordingly, the progeny of subventricular zone (SVZ) progenitor cells that are destined for the olfactory bulb is of particular interest, specifically as there are many facets of these progenitors and their m...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11030305
更新日期：2020-03-13 00:00:00
abstract：:The P-type plasma membrane (PM) H+-ATPase plays a major role during the growth and development of a plant. It is also involved in plant resistance to a variety of biotic and abiotic factors, including salt stress. The PM H+-ATPase gene family has been well characterized in Arabidopsis and other crop plants such as ric...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes11040361
更新日期：2020-03-27 00:00:00
abstract：:Small RNAs play an important role in regulating plant responses to abiotic stress. Depending on the method of salt application, whether sudden or gradual, plants may experience either salt shock or salt stress, respectively. In this study, small RNA expression in response to salt shock and long-term salt stress in par...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes8120369
更新日期：2017-12-05 00:00:00
abstract：:Familial hypercholesterolemia (FH) is a common autosomal codominant disorder, characterized by elevated low-density lipoprotein cholesterol levels causing premature atherosclerotic cardiovascular disease. About 2900 variants of LDLR, APOB, and PCSK9 genes potentially associated with FH have been described earlier. Nev...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes12010066
更新日期：2021-01-06 00:00:00
abstract：:Unbalanced dietary habits and gut dysmotility are causative factors in metabolic and functional gut disorders, including obesity, diabetes, and constipation. Reduction in luminal butyrate synthesis is known to be associated with gut dysbioses, and studies have suggested that restoring butyrate formation in the colon m...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes8120350
更新日期：2017-11-28 00:00:00
abstract：:DNA Helicase B (HELB) is a conserved helicase in higher eukaryotes with roles in the initiation of DNA replication and in the DNA damage and replication stress responses. HELB is a predominately nuclear protein in G1 phase where it is involved in initiation of DNA replication through interactions with DNA topoisomeras...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes11050578
更新日期：2020-05-21 00:00:00
abstract：:The plant circadian clock coordinates environmental signals with internal processes including secondary metabolism, growth, flowering, and volatile emission. Plant tissues are specialized in different functions, and petals conceal the sexual organs while attracting pollinators. Here we analyzed the transcriptional str...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10110860
更新日期：2019-10-30 00:00:00
abstract：:Overweight and obesity are major problems in today's society, driving the prevalence of diabetes and its related complications. It is important to understand the molecular mechanisms underlying the chronic complications in diabetes in order to develop better therapeutic approaches for these conditions. Some of the mos...
journal_title：Genes
pub_type： 杂志文章,评审
doi：10.3390/genes5040926
更新日期：2014-09-29 00:00:00
abstract：:The woody Sonchus alliance consists primarily of woody species of the genus Sonchus (subgenus Dendrosonchus; family Asteraceae). Most members of the alliance are endemic to the oceanic archipelagos in the phytogeographic region of Macaronesia. They display extensive morphological, ecological, and anatomical diversity,...
journal_title：Genes
pub_type： 杂志文章
doi：10.3390/genes10030217
更新日期：2019-03-14 00:00:00
