Inhibition of citric acid accumulation by manganese ions in Aspergillus niger mutants with reduced citrate control of phosphofructokinase.

Abstract:

:Mutant strains of Aspergillus niger with reduced citrate control of carbohydrate catabolism (cic mutants) grow faster than the parent strain on media containing 5% (wt/vol) citrate. The mutants tolerated a higher intracellular citrate concentration than the parent strain. One mutant (cic-7/3) contained phosphofructokinase activity significantly less sensitive towards citrate than the enzyme from the parent strain. When this mutant was grown under citrate-accumulating conditions, acidogenesis was far less sensitive to inhibition by Mn2+ than in the parent strain. Some of the cic mutants also showed altered citrate inhibition of NADP-specific isocitrate dehydrogenase.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Schreferl G,Kubicek CP,Röhr M

doi

10.1128/jb.165.3.1019-1022.1986

subject

Has Abstract

pub_date

1986-03-01 00:00:00

pages

1019-22

issue

3

eissn

0021-9193

issn

1098-5530

journal_volume

165

pub_type

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