Osteogenic Stimulation of Human Adipose-Derived Mesenchymal Stem Cells Using a Fungal Metabolite That Suppresses the Polycomb Group Protein EZH2.

abstract：BACKGROUND:Tendon or ligament tears can decrease patients' quality of life. Many therapeutic interventions are available to treat such injuries. Mesenchymal stem cells (MSCs) have been shown to be effective in treating tendon or ligament tears; however, the use of stem cell-conditioned medium (CM) requires further inve...

journal_title：Stem cells translational medicine

authors： Rhatomy S,Prasetyo TE,Setyawan R,Soekarno NR,Romaniyanto F,Sedjati AP,Sumarwoto T,Utomo DN,Suroto H,Mahyudin F,Prakoeswa CRS

更新日期：2020-08-01 00:00:00

abstract：:The specific cell surface markers on mesenchymal stem/progenitor cells (MSCs) have been poorly defined in vivo, but in one recent study, an MSC subpopulation was directly isolated from a CD271-positive fraction of human bone marrow cells. The aim of this study was to identify circulating CD271(+) MSCs in human periphe...

journal_title：Stem cells translational medicine

authors： Iso Y,Yamaya S,Sato T,Poole CN,Isoyama K,Mimura M,Koba S,Kobayashi Y,Takeyama Y,Spees JL,Suzuki H

更新日期：2012-06-01 00:00:00

abstract：:Accumulating evidence indicates that stem cells (SCs) possess immunomodulatory, anti-inflammatory, and prohealing properties. The mechanisms underlying these functions are being investigated with the final goal to set a solid background for the clinical use of SCs and/or their derivatives. Specialized proresolving lip...

journal_title：Stem cells translational medicine

authors： Romano M,Patruno S,Pomilio A,Recchiuti A

更新日期：2019-10-01 00:00:00

abstract：:γδT cells constitute a small proportion of lymphocytes in peripheral blood. Unlike αβT cells, the anti-tumor activities are exerted through several different pathways in a MHC-unrestricted manner. Thus, immunotherapy using γδT cells is considered to be effective for various types of cancer. Occasionally, however, ex v...

journal_title：Stem cells translational medicine

authors： Watanabe D,Koyanagi-Aoi M,Taniguchi-Ikeda M,Yoshida Y,Azuma T,Aoi T

更新日期：2018-01-01 00:00:00

abstract：UNLABELLED:Histone deacetylase (HDAC) inhibitors possess therapeutic potential to reverse aberrant epigenetic changes associated with cancers, neurological diseases, and immune disorders. Unfortunately, clinical studies with some HDAC inhibitors displayed delayed cardiac adverse effects, such as atrial fibrillation and...

journal_title：Stem cells translational medicine

authors： Kopljar I,Gallacher DJ,De Bondt A,Cougnaud L,Vlaminckx E,Van den Wyngaert I,Lu HR

更新日期：2016-05-01 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) offer an effective platform for studies of human physiology and have revealed new possibilities for disease modeling at the cellular level. These cells also have the potential to be leveraged in the practice of precision medicine, including personalized drug testing. Aortic disea...

journal_title：Stem cells translational medicine

authors： Zhu K,Ma W,Li J,Zhang YS,Zhang W,Lai H,Wang C

更新日期：2021-02-01 00:00:00

abstract：UNLABELLED:Rotator cuff tendon tear is one of the most common causes of chronic shoulder pain and disability. In this study, we investigated the therapeutic effects of ultrasound-guided human umbilical cord blood (UCB)-derived mesenchymal stem cell (MSC) injection to regenerate a full-thickness subscapularis tendon tea...

journal_title：Stem cells translational medicine

authors： Park GY,Kwon DR,Lee SC

更新日期：2015-11-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have been investigated as a clinical therapy to promote tissue repair. However, the disappearance of grafted cells soon after engraftment suggests a possible role as initiators of repair rather than effectors. We evaluated the relative contribution of grafted human MSCs and host stem/prog...

journal_title：Stem cells translational medicine

authors： Shin L,Peterson DA

更新日期：2013-01-01 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) have elicited excitement in both the scientific and ethics communities for their potential to advance basic and translational research. They have been hailed as an alternative to derivation from embryos that provides a virtually unlimited source of pluripotent stem cells for rese...

journal_title：Stem cells translational medicine

authors： Lowenthal J,Lipnick S,Rao M,Hull SC

更新日期：2012-05-01 00:00:00

abstract：:Preterm birth and its complications are the leading cause of neonatal death. The main underlying pathological mechanisms for preterm complications are disruption of the normal maturation processes within the target tissues, interrupted by premature birth. Cord blood, as a new and convenient source of stem cells, may p...

journal_title：Stem cells translational medicine

authors： Ren Z,Xu F,Zhang X,Zhang C,Miao J,Xia X,Kang M,Wei W,Ma T,Zhang Q,Lu L,Wen J,Liu G,Liu K,Wang Q,Yang J

更新日期：2020-02-01 00:00:00

abstract：:To optimize the regenerative proficiency of stem cells, a cardiopoietic protein-based cocktail consisting of multiple growth factors has been developed and advanced into clinical trials for treatment of ischemic heart failure. Streamlining the inductors of cardiopoiesis would address the resource intensive nature of t...

journal_title：Stem cells translational medicine

authors： Li M,Yamada S,Shi A,Singh RD,Rolland TJ,Jeon R,Lopez N,Shelerud L,Terzic A,Behfar A

更新日期：2020-10-24 00:00:00

abstract：UNLABELLED:Studies in hypertension (HTN) pharmacogenomics seek to identify genetic sources of variable antihypertensive drug response. Genetic association studies have detected single-nucleotide polymorphisms (SNPs) that link to drug responses; however, to understand mechanisms underlying how genetic traits alter drug ...

journal_title：Stem cells translational medicine

authors： Biel NM,Santostefano KE,DiVita BB,El Rouby N,Carrasquilla SD,Simmons C,Nakanishi M,Cooper-DeHoff RM,Johnson JA,Terada N

更新日期：2015-12-01 00:00:00

abstract：:High-dose chemotherapy is accompanied by an obligate period of neutropenia. Resulting bacterial and fungal infections are the leading cause of morbidity and mortality in neutropenic patients despite prophylactic antimicrobials and hematopoietic growth factor supplements. Replacing neutrophils in the patient through tr...

journal_title：Stem cells translational medicine

authors： Brunck ME,Nielsen LK

更新日期：2014-04-01 00:00:00

abstract：:Stem cells are promising candidate cells for regenerative applications because they possess high proliferative capacity and the potential to differentiate into other cell types. Mesenchymal stem cells (MSCs) are easily sourced but do not retain their proliferative and multilineage differentiative capabilities after pr...

journal_title：Stem cells translational medicine

authors： Boyette LB,Creasey OA,Guzik L,Lozito T,Tuan RS

更新日期：2014-02-01 00:00:00

abstract：:In the field of disease modeling, induced pluripotent stem cells (iPSCs) have become an appealing choice, especially for diseases that do not have an animal model. They can be generated from patients with known clinical features and compared with cells from healthy controls to identify the biological bases of disease....

journal_title：Stem cells translational medicine

authors： Vitale AM,Matigian NA,Ravishankar S,Bellette B,Wood SA,Wolvetang EJ,Mackay-Sim A

更新日期：2012-09-01 00:00:00

abstract：UNLABELLED:: Chronic rotator cuff (RC) tears are a common and debilitating injury, characterized by dramatic expansion of adipose tissue, muscle atrophy, and limited functional recovery. The role of adipose expansion in RC pathology is unknown; however, given the identified paracrine/endocrine regulation by other adipo...

journal_title：Stem cells translational medicine

authors： Meyer GA,Gibbons MC,Sato E,Lane JG,Ward SR,Engler AJ

更新日期：2015-07-01 00:00:00

abstract：:Multipotent mesenchymal stromal cell (MSC) therapy and costimulation blockade are two immunomodulatory strategies being developed concomitantly for the treatment of immunological diseases. Both of these strategies have the capacity to inhibit immune responses and induce regulatory T cells; however, their ability to sy...

journal_title：Stem cells translational medicine

authors： Takahashi T,Tibell A,Ljung K,Saito Y,Gronlund A,Osterholm C,Holgersson J,Lundgren T,Ericzon BG,Corbascio M,Kumagai-Braesch M

更新日期：2014-12-01 00:00:00

abstract：:Techniques that enable longitudinal tracking of cell fate after myocardial delivery are imperative for optimizing the efficacy of cell-based cardiac therapies. However, these approaches have been underutilized in preclinical models and clinical trials, and there is considerable demand for site-specific strategies achi...

journal_title：Stem cells translational medicine

authors： Ostrominski JW,Yada RC,Sato N,Klein M,Blinova K,Patel D,Valadez R,Palisoc M,Pittaluga S,Peng KW,San H,Lin Y,Basuli F,Zhang X,Swenson RE,Haigney M,Choyke PL,Zou J,Boehm M,Hong SG,Dunbar CE

更新日期：2020-10-01 00:00:00

abstract：:Lamin A (LMNA)-linked lipodystrophies may be either genetic (associated with LMNA mutations) or acquired (associated with the use of human immunodeficiency virus protease inhibitors [PIs]), and in both cases they share clinical features such as anomalous distribution of body fat or generalized loss of adipose tissue, ...

journal_title：Stem cells translational medicine

authors： Ruiz de Eguino G,Infante A,Schlangen K,Aransay AM,Fullaondo A,Soriano M,García-Verdugo JM,Martín AG,Rodríguez CI

更新日期：2012-04-01 00:00:00

abstract：:Knee osteoarthritis (OA) is a leading cause of pain and disability. Although conventional treatments show modest benefits, pilot and phase I/II trials with bone marrow (BM) and adipose-derived (AD) mesenchymal stromal cells (MSCs) point to the feasibility, safety, and occurrence of clinical and structural improvement ...

journal_title：Stem cells translational medicine

authors： Matas J,Orrego M,Amenabar D,Infante C,Tapia-Limonchi R,Cadiz MI,Alcayaga-Miranda F,González PL,Muse E,Khoury M,Figueroa FE,Espinoza F

更新日期：2019-03-01 00:00:00

abstract：:Studies of human cerebral cortex development are limited by difficulties in accessing and manipulating human neural tissue at specific development stages. We have derived human radial glia (hRG), which are responsible for most cerebral cortex neurogenesis, from human pluripotent stem cells. These hRG display the hallm...

journal_title：Stem cells translational medicine

authors： Duan L,Peng CY,Pan L,Kessler JA

更新日期：2015-05-01 00:00:00

abstract：:Steroid-induced osteonecrosis of the femoral head (ONFH) is characterized by decreased osteogenesis, angiogenesis, and increased adipogenesis. While bone tissue engineering has been widely investigated to treat ONFH, its therapeutic effects remain unsatisfactory. Therefore, further studies are required to determine op...

journal_title：Stem cells translational medicine

authors： Xu H,Wang C,Liu C,Peng Z,Li J,Jin Y,Wang Y,Guo J,Zhu L

更新日期：2021-01-13 00:00:00

abstract：:The translation of stem cell-based regenerative solutions from the laboratory to the clinic is often hindered by the culture conditions used to expand cell populations. Although fetal bovine serum (FBS) is widely used, regulatory bodies and safety concerns encourage alternative, xeno-free culturing practices. In an at...

journal_title：Stem cells translational medicine

authors： Roberts SJ,Owen HC,Tam WL,Solie L,Van Cromphaut SJ,Van den Berghe G,Luyten FP

更新日期：2014-02-01 00:00:00

abstract：:Limbal stem cell (LSC) deficiency is a visually debilitating condition caused by abnormal maintenance of LSCs. It is treated by transplantation of donor-derived limbal epithelial cells (LECs), the success of which depends on the presence and quality of LSCs within the transplant. Understanding the immunobiological res...

journal_title：Stem cells translational medicine

authors： Shaharuddin B,Ahmad S,Md Latar N,Ali S,Meeson A

更新日期：2017-03-01 00:00:00

abstract：:The differentiation of human stem cells into insulin secreting beta-like cells holds great promise to treat diabetes. Current protocols drive stem cells through stages of directed differentiation and maturation and produce cells that secrete insulin in response to glucose. Further refinements are now needed to faithfu...

journal_title：Stem cells translational medicine

authors： Singh R,Cottle L,Loudovaris T,Xiao D,Yang P,Thomas HE,Kebede MA,Thorn P

更新日期：2020-11-04 00:00:00

abstract：:Recent reports have indicated human embryonic stem cells-derived midbrain dopamine (mDA) neurons as proper cell resources for use in Parkinson's disease (PD) therapy. Nevertheless, no detailed and systematic study has been conducted to identify which differentiation stages of mDA cells are most suitable for transplant...

journal_title：Stem cells translational medicine

authors： Qiu L,Liao MC,Chen AK,Wei S,Xie S,Reuveny S,Zhou ZD,Hunziker W,Tan EK,Oh SKW,Zeng L

更新日期：2017-09-01 00:00:00

abstract：:Adipose-derived stem cells (ASCs) are being tested in clinical trials related to cell-based regenerative therapies. Although most of the current expansion protocols for ASCs use fetal calf serum (FCS), xenogeneic-free medium supplements are greatly desired. This study aims to compare the effect of FCS, human platelet ...

journal_title：Stem cells translational medicine

authors： Riis S,Nielsen FM,Pennisi CP,Zachar V,Fink T

更新日期：2016-03-01 00:00:00

abstract：:Global cerebral ischemia (GCI) is the leading cause of a poor prognosis even after successful resuscitation from cardiac arrest. Therapeutic induction of hypothermia (TH) is the only proven therapy-and current standard care-for GCI after cardiac arrest; however, its application has been significantly limited owing to ...

journal_title：Stem cells translational medicine

authors： Chung TN,Kim JH,Choi BY,Chung SP,Kwon SW,Suh SW

更新日期：2015-02-01 00:00:00

abstract：UNLABELLED:The oral cavity possesses a diverse microflora, yet recurrent infections within healthy individuals are rare. Wound healing within the buccal mucosa is preferential, potentially because of the presence of oral mucosal lamina propria-progenitor cells (OMLP-PCs). In addition to their multipotency, OMLP-PCs dem...

journal_title：Stem cells translational medicine

authors： Board-Davies E,Moses R,Sloan A,Stephens P,Davies LC

更新日期：2015-11-01 00:00:00

abstract：:The potential plasticity and therapeutic utility in tissue regeneration of human adipose-derived stem cells (ASCs) isolated from adult adipose tissue have recently been highlighted. The use of autologous platelet-rich plasma (PRP) represents an alternative strategy in regenerative medicine for the local release of mul...

journal_title：Stem cells translational medicine

authors： Cervelli V,Scioli MG,Gentile P,Doldo E,Bonanno E,Spagnoli LG,Orlandi A

更新日期：2012-03-01 00:00:00