Proresolving Lipid Mediators and Receptors in Stem Cell Biology: Concise Review.

abstract：:Induced pluripotent stem cells (iPSCs) offer an effective platform for studies of human physiology and have revealed new possibilities for disease modeling at the cellular level. These cells also have the potential to be leveraged in the practice of precision medicine, including personalized drug testing. Aortic disea...

journal_title：Stem cells translational medicine

authors： Zhu K,Ma W,Li J,Zhang YS,Zhang W,Lai H,Wang C

更新日期：2021-02-01 00:00:00

abstract：:Limbal stem cell (LSC) deficiency is a visually debilitating condition caused by abnormal maintenance of LSCs. It is treated by transplantation of donor-derived limbal epithelial cells (LECs), the success of which depends on the presence and quality of LSCs within the transplant. Understanding the immunobiological res...

journal_title：Stem cells translational medicine

authors： Shaharuddin B,Ahmad S,Md Latar N,Ali S,Meeson A

更新日期：2017-03-01 00:00:00

abstract：:Repair of injured lungs represents a longstanding therapeutic challenge. We recently demonstrated that human and mouse embryonic lung tissue from the canalicular stage of development are enriched with lung progenitors, and that a single cell suspension of canalicular lungs can be used for transplantation, provided tha...

journal_title：Stem cells translational medicine

authors： Milman Krentsis I,Rosen C,Shezen E,Aronovich A,Nathanson B,Bachar-Lustig E,Berkman N,Assayag M,Shakhar G,Feferman T,Orgad R,Reisner Y

更新日期：2018-01-01 00:00:00

abstract：:: Liver fibrosis represents the end stage of chronic liver inflammatory diseases and is defined by the abnormal accumulation of extracellular matrix in the liver. Advanced liver fibrosis results in cirrhosis, liver failure, and portal hypertension. Liver transplantation has been the most effective treatment for these ...

journal_title：Stem cells translational medicine

authors： Lee PH,Tu CT,Hsiao CC,Tsai MS,Ho CM,Cheng NC,Hung TM,Shih DT

更新日期：2016-11-01 00:00:00

abstract：:Techniques that enable longitudinal tracking of cell fate after myocardial delivery are imperative for optimizing the efficacy of cell-based cardiac therapies. However, these approaches have been underutilized in preclinical models and clinical trials, and there is considerable demand for site-specific strategies achi...

journal_title：Stem cells translational medicine

authors： Ostrominski JW,Yada RC,Sato N,Klein M,Blinova K,Patel D,Valadez R,Palisoc M,Pittaluga S,Peng KW,San H,Lin Y,Basuli F,Zhang X,Swenson RE,Haigney M,Choyke PL,Zou J,Boehm M,Hong SG,Dunbar CE

更新日期：2020-10-01 00:00:00

abstract：:The present first-in-human clinical trial evaluated the safety and feasibility of a newly developed and cryopreserved Cardiology Stem Cell Centre adipose-derived stromal cell (CSCC_ASC) product from healthy donors for intramyocardial injection in ten patients with ischemic heart disease and ischemic heart failure (IHF...

journal_title：Stem cells translational medicine

authors： Kastrup J,Haack-Sørensen M,Juhl M,Harary Søndergaard R,Follin B,Drozd Lund L,Mønsted Johansen E,Ali Qayyum A,Bruun Mathiasen A,Jørgensen E,Helqvist S,Jørgen Elberg J,Bruunsgaard H,Ekblond A

更新日期：2017-11-01 00:00:00

abstract：:The vascular wall stores mesenchymal progenitor cells which are able to induce bone regeneration, via direct and paracrine mechanisms. Although much is known regarding perivascular cell regulation of osteoblasts, their regulation of osteoclasts, and by extension utility in states of high bone resorption, is not known....

journal_title：Stem cells translational medicine

authors： Negri S,Wang Y,Sono T,Lee S,Hsu GC,Xu J,Meyers CA,Qin Q,Broderick K,Witwer KW,Peault B,James AW

更新日期：2020-12-01 00:00:00

abstract：:Although mesenchymal stromal cells (MSCs) possess immunomodulatory properties and exhibit promising efficacy against chronic graft-versus-host disease (cGVHD), little is known about the immune changes by which MSCs ameliorate cGVHD in vivo. Recent studies have suggested that B lymphocytes might play an important role ...

journal_title：Stem cells translational medicine

authors： Peng Y,Chen X,Liu Q,Xu D,Zheng H,Liu L,Liu Q,Liu M,Fan Z,Sun J,Li X,Zou R,Xiang AP

更新日期：2014-09-01 00:00:00

abstract：:Despite approaches in regenerative medicine using stem cells, bio-engineered scaffolds, and targeted drug delivery to enhance human tissue repair, clinicians remain unable to regenerate large-scale, multi-tissue defects in situ. The study of regenerative biology using mammalian models of complex tissue regeneration of...

journal_title：Stem cells translational medicine

authors： Simkin J,Seifert AW

更新日期：2018-02-01 00:00:00

abstract：:The translation of stem cell-based regenerative solutions from the laboratory to the clinic is often hindered by the culture conditions used to expand cell populations. Although fetal bovine serum (FBS) is widely used, regulatory bodies and safety concerns encourage alternative, xeno-free culturing practices. In an at...

journal_title：Stem cells translational medicine

authors： Roberts SJ,Owen HC,Tam WL,Solie L,Van Cromphaut SJ,Van den Berghe G,Luyten FP

更新日期：2014-02-01 00:00:00

abstract：:: Fast remyelination by endogenous oligodendrocyte precursor cells (OPCs) is essential to prevent axonal and subsequent retrograde neuronal degeneration in demyelinating lesions in multiple sclerosis (MS). In chronic lesions, however, the remyelination capacity of OPCs becomes insufficient. Cell therapy with exogenous...

journal_title：Stem cells translational medicine

authors： Thiruvalluvan A,Czepiel M,Kap YA,Mantingh-Otter I,Vainchtein I,Kuipers J,Bijlard M,Baron W,Giepmans B,Brück W,'t Hart BA,Boddeke E,Copray S

更新日期：2016-11-01 00:00:00

abstract：UNLABELLED:Rotator cuff tendon tear is one of the most common causes of chronic shoulder pain and disability. In this study, we investigated the therapeutic effects of ultrasound-guided human umbilical cord blood (UCB)-derived mesenchymal stem cell (MSC) injection to regenerate a full-thickness subscapularis tendon tea...

journal_title：Stem cells translational medicine

authors： Park GY,Kwon DR,Lee SC

更新日期：2015-11-01 00:00:00

abstract：UNLABELLED:The oral cavity possesses a diverse microflora, yet recurrent infections within healthy individuals are rare. Wound healing within the buccal mucosa is preferential, potentially because of the presence of oral mucosal lamina propria-progenitor cells (OMLP-PCs). In addition to their multipotency, OMLP-PCs dem...

journal_title：Stem cells translational medicine

authors： Board-Davies E,Moses R,Sloan A,Stephens P,Davies LC

更新日期：2015-11-01 00:00:00

abstract：:The kidney is a specialized low-regenerative organ with several different types of cellular lineages; however, the identity of renal stem/progenitor cells with nephrogenic potential and their preferred niche(s) are largely unknown and debated. Most of the therapeutic approaches to kidney regeneration are based on admi...

journal_title：Stem cells translational medicine

authors： Aggarwal S,Moggio A,Bussolati B

更新日期：2013-12-01 00:00:00

abstract：UNLABELLED:Studies in hypertension (HTN) pharmacogenomics seek to identify genetic sources of variable antihypertensive drug response. Genetic association studies have detected single-nucleotide polymorphisms (SNPs) that link to drug responses; however, to understand mechanisms underlying how genetic traits alter drug ...

journal_title：Stem cells translational medicine

authors： Biel NM,Santostefano KE,DiVita BB,El Rouby N,Carrasquilla SD,Simmons C,Nakanishi M,Cooper-DeHoff RM,Johnson JA,Terada N

更新日期：2015-12-01 00:00:00

abstract：:Basic and translational research on lung biology has discovered multiple progenitor cell types, specialized or facultative, responsible for turnover, renewal, and repair. Isolation of populations of resident lung progenitor cells (LPCs) has been described by multiple protocols, and some have been successfully applied ...

journal_title：Stem cells translational medicine

authors： Chimenti I,Pagano F,Angelini F,Siciliano C,Mangino G,Picchio V,De Falco E,Peruzzi M,Carnevale R,Ibrahim M,Biondi-Zoccai G,Messina E,Frati G

更新日期：2017-03-01 00:00:00

abstract：:Cancer stem cells (CSCs) are a subpopulation of tumor cells that have strong self-renewal capabilities and may contribute to the failure of conventional cancer therapies. Hence, therapeutics homing in on CSCs represent a novel and promising approach that may eradicate malignant tumors. However, the lack of information...

journal_title：Stem cells translational medicine

authors： Hu X,Cong Y,Luo HH,Wu S,Zhao LE,Liu Q,Yang Y

更新日期：2017-02-01 00:00:00

abstract：:Heart diseases (HDs) are the leading cause of morbidity and mortality worldwide. Despite remarkable clinical progress made, current therapies cannot restore the lost myocardium, and the correlation of genotype to phenotype of many HDs is poorly modeled. In the past two decades, with the rapid developments of human plu...

journal_title：Stem cells translational medicine

authors： Li Q,Wang J,Wu Q,Cao N,Yang HT

更新日期：2020-10-01 00:00:00

abstract：:Burns not only destroy the barrier function of the skin but also alter the perceptions of pain, temperature, and touch. Different strategies have been developed over the years to cover deep and extensive burns with the ultimate goal of regenerating the barrier function of the epidermis while recovering an acceptable a...

journal_title：Stem cells translational medicine

authors： Blais M,Parenteau-Bareil R,Cadau S,Berthod F

更新日期：2013-07-01 00:00:00

abstract：:The development of a California-based induced pluripotent stem cell (iPSC) bank based on human leukocyte antigen (HLA) haplotype matching represents a significant challenge and a valuable opportunity for the advancement of regenerative medicine. However, previously published models of iPSC banks have neither addressed...

journal_title：Stem cells translational medicine

authors： Pappas DJ,Gourraud PA,Le Gall C,Laurent J,Trounson A,DeWitt N,Talib S

更新日期：2015-05-01 00:00:00

abstract：:Animal models show that systemically administered bone marrow-derived mesenchymal stem cells (MSCs) home to sites of primary and metastatic prostate cancer (PC)-making them candidates to selectively deliver cytotoxic agents. To further assess this potential as a cell-based therapeutic vehicle, a phase I study testing ...

journal_title：Stem cells translational medicine

authors： Schweizer MT,Wang H,Bivalacqua TJ,Partin AW,Lim SJ,Chapman C,Abdallah R,Levy O,Bhowmick NA,Karp JM,De Marzo A,Isaacs JT,Brennen WN,Denmeade SR

更新日期：2019-05-01 00:00:00

abstract：:γδT cells constitute a small proportion of lymphocytes in peripheral blood. Unlike αβT cells, the anti-tumor activities are exerted through several different pathways in a MHC-unrestricted manner. Thus, immunotherapy using γδT cells is considered to be effective for various types of cancer. Occasionally, however, ex v...

journal_title：Stem cells translational medicine

authors： Watanabe D,Koyanagi-Aoi M,Taniguchi-Ikeda M,Yoshida Y,Azuma T,Aoi T

更新日期：2018-01-01 00:00:00

abstract：:Similar to the disease affecting humans, osteoarthritis (OA) is a painful musculoskeletal condition affecting 20% of the adult canine population. Several solutions have been proposed, but the results achieved to date are far from being satisfactory. New approaches, such as intra-articular delivery of cells (including ...

journal_title：Stem cells translational medicine

authors： Zeira O,Scaccia S,Pettinari L,Ghezzi E,Asiag N,Martinelli L,Zahirpour D,Dumas MP,Konar M,Lupi DM,Fiette L,Pascucci L,Leonardi L,Cliff A,Alessandri G,Pessina A,Spaziante D,Aralla M

更新日期：2018-11-01 00:00:00

abstract：:The potential of autologous cell-based therapies including those using multipotent mesenchymal stromal cells (MSCs) is being investigated for multiple sclerosis (MS) and other neurological conditions. However, the phenotype of MSC in neurological diseases has not been fully characterized. We have previously shown that...

journal_title：Stem cells translational medicine

authors： Redondo J,Sarkar P,Kemp K,Heesom KJ,Wilkins A,Scolding NJ,Rice CM

更新日期：2018-10-01 00:00:00

abstract：:Adipose-derived stem cells (ASCs) are being tested in clinical trials related to cell-based regenerative therapies. Although most of the current expansion protocols for ASCs use fetal calf serum (FCS), xenogeneic-free medium supplements are greatly desired. This study aims to compare the effect of FCS, human platelet ...

journal_title：Stem cells translational medicine

authors： Riis S,Nielsen FM,Pennisi CP,Zachar V,Fink T

更新日期：2016-03-01 00:00:00

abstract：UNLABELLED:Human cord blood (CB)-derived hematopoietic stem cells (HSCs) are an interesting source for HSC transplantation. However, the number of collected CB-HSCs is often too low for one transplantation; therefore, ex vivo expansion of CB-HSCs is desirable. Current expansion protocols are based on the use of cytokin...

journal_title：Stem cells translational medicine

authors： Heinz N,Ehrnström B,Schambach A,Schwarzer A,Modlich U,Schiedlmeier B

更新日期：2015-09-01 00:00:00

abstract：:: Phosphatase and tension homolog (PTEN) is a widely known negative regulator of insulin/phosphatidylinositol 3-kinase (PI3K) signaling. The PI3K/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) and Ras-extracellular signal-regulated kinase (Ras-ERK) signaling pathways are the chief mechanisms controlling the surviva...

journal_title：Stem cells translational medicine

authors： Lee JE,Lim MS,Park JH,Park CH,Koh HC

更新日期：2016-10-01 00:00:00

abstract：UNLABELLED:Duchenne muscular dystrophy (DMD), caused by mutations in the dystrophin gene, is the most common muscular dystrophy. Characterized by rounds of muscle degeneration and regeneration, DMD features progressive muscle wasting and is fatal. One approach for treatment is transplantation of muscle progenitor cells...

journal_title：Stem cells translational medicine

authors： Lala-Tabbert N,Fu D,Wiper-Bergeron N

更新日期：2016-04-01 00:00:00

abstract：:Human pluripotent stem cells have the potential to promote biological studies and accelerate drug discovery efforts by making possible direct experimentation on a variety of human cell types of interest. However, stem cell cultures are generally heterogeneous and efficient differentiation and purification protocols ar...

journal_title：Stem cells translational medicine

authors： Sluch VM,Chamling X,Liu MM,Berlinicke CA,Cheng J,Mitchell KL,Welsbie DS,Zack DJ

更新日期：2017-11-01 00:00:00

abstract：UNLABELLED:We evaluated the association of diabetes and insulin resistance with the response to cell therapy in patients with nonischemic dilated cardiomyopathy (DCM). A total of 45 outpatients with DCM received granulocyte colony-stimulating factor for 5 days. CD34(+) cells were then collected by apheresis and injecte...

journal_title：Stem cells translational medicine

authors： Vrtovec B,Sever M,Jensterle M,Poglajen G,Janez A,Kravos N,Zemljic G,Cukjati M,Cernelc P,Haddad F,Wu JC,Jorde UP

更新日期：2016-05-01 00:00:00