Abstract:
:Heart diseases (HDs) are the leading cause of morbidity and mortality worldwide. Despite remarkable clinical progress made, current therapies cannot restore the lost myocardium, and the correlation of genotype to phenotype of many HDs is poorly modeled. In the past two decades, with the rapid developments of human pluripotent stem cell (hPSC) biology and technology that allow the efficient preparation of cardiomyocytes from individual patients, tremendous efforts have been made for using hPSC-derived cardiomyocytes in preclinical and clinical cardiac therapy as well as in dissection of HD mechanisms to develop new methods for disease prediction and treatment. However, their applications have been hampered by several obstacles. Here, we discuss recent advances, remaining challenges, and the potential solutions to advance this field.
journal_name
Stem Cells Transl Medjournal_title
Stem cells translational medicineauthors
Li Q,Wang J,Wu Q,Cao N,Yang HTdoi
10.1002/sctm.19-0340subject
Has Abstractpub_date
2020-10-01 00:00:00pages
1121-1128issue
10eissn
2157-6564issn
2157-6580journal_volume
9pub_type
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