Modeling aortic diseases using induced pluripotent stem cells.

abstract：:Gaucher disease (GD) is the most common lysosomal storage disease resulting from mutations in the lysosomal enzyme glucocerebrosidase (GCase). The hematopoietic abnormalities in GD include the presence of characteristic Gaucher macrophages that infiltrate patient tissues and cytopenias. At present, it is not clear whe...

journal_title：Stem cells translational medicine

authors： Sgambato JA,Park TS,Miller D,Panicker LM,Sidransky E,Lun Y,Awad O,Bentzen SM,Zambidis ET,Feldman RA

更新日期：2015-08-01 00:00:00

abstract：:: Liver fibrosis represents the end stage of chronic liver inflammatory diseases and is defined by the abnormal accumulation of extracellular matrix in the liver. Advanced liver fibrosis results in cirrhosis, liver failure, and portal hypertension. Liver transplantation has been the most effective treatment for these ...

journal_title：Stem cells translational medicine

authors： Lee PH,Tu CT,Hsiao CC,Tsai MS,Ho CM,Cheng NC,Hung TM,Shih DT

更新日期：2016-11-01 00:00:00

abstract：:Peripheral nerve injury presents significant therapeutic challenges for recovery of motor and sensory function in patients. Different clinical approaches exist but to date there has been no consensus on the most effective method of treatment. Here, we investigate a novel approach to peripheral nerve repair using olfac...

journal_title：Stem cells translational medicine

authors： Roche P,Alekseeva T,Widaa A,Ryan A,Matsiko A,Walsh M,Duffy GP,O'Brien FJ

更新日期：2017-10-01 00:00:00

abstract：:Biomimetic scaffolds are extremely versatile in terms of chemical composition and physical properties, which can be defined to accomplish specific applications. One property that can be added is the production/release of bioactive soluble factors, either directly from the biomaterial, or from cells embedded within the...

journal_title：Stem cells translational medicine

authors： Menale C,Campodoni E,Palagano E,Mantero S,Erreni M,Inforzato A,Fontana E,Schena F,Van't Hof R,Sandri M,Tampieri A,Villa A,Sobacchi C

更新日期：2019-01-01 00:00:00

abstract：:Human-induced pluripotent stem cells (hiPSCs)-based cell therapy holds promise for treating stress urinary incontinence (SUI). However, safety concerns, especially tumorgenic potential of residual undifferentiated cells in hiPSC derivatives, are major barriers for its clinical translation. An efficient, fast and clini...

journal_title：Stem cells translational medicine

authors： Li Y,Green M,Wen Y,Wei Y,Wani P,Wang Z,Reijo Pera R,Chen B

更新日期：2017-04-01 00:00:00

abstract：:Although mesenchymal stromal cells (MSCs) possess immunomodulatory properties and exhibit promising efficacy against chronic graft-versus-host disease (cGVHD), little is known about the immune changes by which MSCs ameliorate cGVHD in vivo. Recent studies have suggested that B lymphocytes might play an important role ...

journal_title：Stem cells translational medicine

authors： Peng Y,Chen X,Liu Q,Xu D,Zheng H,Liu L,Liu Q,Liu M,Fan Z,Sun J,Li X,Zou R,Xiang AP

更新日期：2014-09-01 00:00:00

abstract：:Burns not only destroy the barrier function of the skin but also alter the perceptions of pain, temperature, and touch. Different strategies have been developed over the years to cover deep and extensive burns with the ultimate goal of regenerating the barrier function of the epidermis while recovering an acceptable a...

journal_title：Stem cells translational medicine

authors： Blais M,Parenteau-Bareil R,Cadau S,Berthod F

更新日期：2013-07-01 00:00:00

abstract：:The specific cell surface markers on mesenchymal stem/progenitor cells (MSCs) have been poorly defined in vivo, but in one recent study, an MSC subpopulation was directly isolated from a CD271-positive fraction of human bone marrow cells. The aim of this study was to identify circulating CD271(+) MSCs in human periphe...

journal_title：Stem cells translational medicine

authors： Iso Y,Yamaya S,Sato T,Poole CN,Isoyama K,Mimura M,Koba S,Kobayashi Y,Takeyama Y,Spees JL,Suzuki H

更新日期：2012-06-01 00:00:00

abstract：:Despite approaches in regenerative medicine using stem cells, bio-engineered scaffolds, and targeted drug delivery to enhance human tissue repair, clinicians remain unable to regenerate large-scale, multi-tissue defects in situ. The study of regenerative biology using mammalian models of complex tissue regeneration of...

journal_title：Stem cells translational medicine

authors： Simkin J,Seifert AW

更新日期：2018-02-01 00:00:00

abstract：UNLABELLED:Cell secretion is an important mechanism for stem cell-based therapeutic angiogenesis, along with cell differentiation to vascular endothelial cells or smooth muscle cells. Cell-released microvesicles (MVs) have been recently implicated to play an essential role in intercellular communication. The purpose of...

journal_title：Stem cells translational medicine

authors： Kang T,Jones TM,Naddell C,Bacanamwo M,Calvert JW,Thompson WE,Bond VC,Chen YE,Liu D

更新日期：2016-04-01 00:00:00

abstract：:Standardization guidelines for human pluripotent stem cells are still very broadly defined, despite ongoing clinical trials in the U.S., U.K., and Japan. The requirements for validation of human embryonic (hESCs) and induced pluripotent stem cells (iPSCs) in general follow the regulations for other clinically complian...

journal_title：Stem cells translational medicine

authors： Devito L,Petrova A,Miere C,Codognotto S,Blakely N,Lovatt A,Ogilvie C,Khalaf Y,Ilic D

更新日期：2014-10-01 00:00:00

abstract：:Animal models show that systemically administered bone marrow-derived mesenchymal stem cells (MSCs) home to sites of primary and metastatic prostate cancer (PC)-making them candidates to selectively deliver cytotoxic agents. To further assess this potential as a cell-based therapeutic vehicle, a phase I study testing ...

journal_title：Stem cells translational medicine

authors： Schweizer MT,Wang H,Bivalacqua TJ,Partin AW,Lim SJ,Chapman C,Abdallah R,Levy O,Bhowmick NA,Karp JM,De Marzo A,Isaacs JT,Brennen WN,Denmeade SR

更新日期：2019-05-01 00:00:00

abstract：:Studies of human cerebral cortex development are limited by difficulties in accessing and manipulating human neural tissue at specific development stages. We have derived human radial glia (hRG), which are responsible for most cerebral cortex neurogenesis, from human pluripotent stem cells. These hRG display the hallm...

journal_title：Stem cells translational medicine

authors： Duan L,Peng CY,Pan L,Kessler JA

更新日期：2015-05-01 00:00:00

abstract：UNLABELLED:The oral cavity possesses a diverse microflora, yet recurrent infections within healthy individuals are rare. Wound healing within the buccal mucosa is preferential, potentially because of the presence of oral mucosal lamina propria-progenitor cells (OMLP-PCs). In addition to their multipotency, OMLP-PCs dem...

journal_title：Stem cells translational medicine

authors： Board-Davies E,Moses R,Sloan A,Stephens P,Davies LC

更新日期：2015-11-01 00:00:00

abstract：:Tissue regeneration using progenitor cell-based therapy has the potential to aid in the healing of a diverse range of pathologies, ranging from short-gut syndrome to spinal cord lesions. However, there are numerous hurdles to be overcome prior to the widespread application of these cells in the clinical setting. One o...

journal_title：Stem cells translational medicine

authors： Hyun J,Grova M,Nejadnik H,Lo D,Morrison S,Montoro D,Chung M,Zimmermann A,Walmsley GG,Lee M,Daldrup-Link H,Wan DC,Longaker MT

更新日期：2013-09-01 00:00:00

abstract：:Lamin A (LMNA)-linked lipodystrophies may be either genetic (associated with LMNA mutations) or acquired (associated with the use of human immunodeficiency virus protease inhibitors [PIs]), and in both cases they share clinical features such as anomalous distribution of body fat or generalized loss of adipose tissue, ...

journal_title：Stem cells translational medicine

authors： Ruiz de Eguino G,Infante A,Schlangen K,Aransay AM,Fullaondo A,Soriano M,García-Verdugo JM,Martín AG,Rodríguez CI

更新日期：2012-04-01 00:00:00

abstract：:Gaucher disease, the most prevalent metabolic storage disorder, is caused by mutations in the glucocerebrosidase gene GBA1, which lead to the accumulation of glucosylceramide (GlcCer) in affected cells. Gaucher disease type 1 (GD1), although defined as nonneuronopathic subtype, is accompanied by an increased risk of P...

journal_title：Stem cells translational medicine

authors： Akiyama T,Sato S,Ko SBH,Sano O,Sato S,Saito M,Nagai H,Ko MSH,Iwata H

更新日期：2020-12-20 00:00:00

abstract：UNLABELLED:The California Institute for Regenerative Medicine (CIRM) has invested approximately $70 million in programs targeting various orthopedic indications, including osteoporosis, bone fracture healing, vertebral compression fractures, and several others. The present article serves to outline the current state of...

journal_title：Stem cells translational medicine

authors： Littman N,Abo A

更新日期：2015-11-01 00:00:00

abstract：:Owing to the rapid progress in stem cell research (SCR) and regenerative medicine (RM), society's expectation and interest in these fields are increasing. For effective communication on issues concerning SCR and RM, surveys for understanding the interests of stakeholders is essential. For this purpose, we conducted a ...

journal_title：Stem cells translational medicine

authors： Shineha R,Inoue Y,Ikka T,Kishimoto A,Yashiro Y

更新日期：2018-02-01 00:00:00

abstract：:There is a need among patients suffering from drug-resistant epilepsy (DRE) for more efficient and less toxic treatments. The objective of the present study was to assess the safety, feasibility, and potential efficacy of autologous bone marrow cell transplantation in pediatric patients with DRE. Two females and two m...

journal_title：Stem cells translational medicine

authors： Milczarek O,Jarocha D,Starowicz-Filip A,Kwiatkowski S,Badyra B,Majka M

更新日期：2018-01-01 00:00:00

abstract：:Stem cell therapy is a promising strategy for tissue regeneration. The therapeutic benefits of cell therapy are mediated by both direct and indirect mechanisms. However, the application of stem cell therapy in the clinic is hampered by several limitations. This concise review provides a brief introduction into stem ce...

journal_title：Stem cells translational medicine

authors： Tang JN,Cores J,Huang K,Cui XL,Luo L,Zhang JY,Li TS,Qian L,Cheng K

更新日期：2018-04-01 00:00:00

abstract：:Adult hemoglobin composed of α- and β-globin reflects a change from expression of embryonic ε- and fetal γ-globin to adult β-globin in human erythroid cells, so-called globin switching. Human pluripotent stem cells (hPSCs) are a potential source for in vitro erythrocyte production, but they show prominent expression o...

journal_title：Stem cells translational medicine

authors： Ochi K,Takayama N,Hirose S,Nakahata T,Nakauchi H,Eto K

更新日期：2014-07-01 00:00:00

abstract：:Stem cells have been widely used in tendon tissue engineering. The lack of refined and controlled differentiation strategy hampers the tendon repair and regeneration. This study aimed to find new effective differentiation factors for stepwise tenogenic differentiation. By microarray screening, the transcript factor Fo...

journal_title：Stem cells translational medicine

authors： Chen J,Zhang E,Zhang W,Liu Z,Lu P,Zhu T,Yin Z,Backman LJ,Liu H,Chen X,Ouyang H

更新日期：2017-11-01 00:00:00

abstract：:Mesenchymal stem cells (multipotent stromal cells; MSCs) have been under investigation for the treatment of diverse diseases, with many promising outcomes achieved in animal models and clinical trials. The biological activity of MSC therapies has not been fully resolved which is critical to rationalizing their use and...

journal_title：Stem cells translational medicine

authors： Stavely R,Nurgali K

更新日期：2020-09-01 00:00:00

abstract：:Cancer stem cells play a critical role in disease initiation and insensitivity to chemotherapy in numerous hematologic malignancies and some solid tumors, and these stem cells need to be eradicated to achieve a cure. Key to successful targeting of cancer stem cells is to identify and functionally test critical target ...

journal_title：Stem cells translational medicine

authors： Zhang H,Li S

更新日期：2019-08-01 00:00:00

abstract：:Global cerebral ischemia (GCI) is the leading cause of a poor prognosis even after successful resuscitation from cardiac arrest. Therapeutic induction of hypothermia (TH) is the only proven therapy-and current standard care-for GCI after cardiac arrest; however, its application has been significantly limited owing to ...

journal_title：Stem cells translational medicine

authors： Chung TN,Kim JH,Choi BY,Chung SP,Kwon SW,Suh SW

更新日期：2015-02-01 00:00:00

abstract：:Cell-based therapies have gained interest as a potential treatment method in cardiovascular disease in the past two decades, peripheral artery disease amongst others. Initial pre-clinical and small pilot clinical studies showed promising effects of cell therapy in peripheral artery disease and chronic limb-threatening...

journal_title：Stem cells translational medicine

authors： Teraa M,Gremmels H,Wijnand JGJ,Verhaar MC

更新日期：2018-12-01 00:00:00

abstract：UNLABELLED:Histone deacetylase (HDAC) inhibitors possess therapeutic potential to reverse aberrant epigenetic changes associated with cancers, neurological diseases, and immune disorders. Unfortunately, clinical studies with some HDAC inhibitors displayed delayed cardiac adverse effects, such as atrial fibrillation and...

journal_title：Stem cells translational medicine

authors： Kopljar I,Gallacher DJ,De Bondt A,Cougnaud L,Vlaminckx E,Van den Wyngaert I,Lu HR

更新日期：2016-05-01 00:00:00

abstract：:Esophageal anastomotic leakage (EAL) is a devastating complication for esophagectomy but the available therapies are unsatisfactory. Due to the healing effects of mesenchymal stromal cells (MSCs) and supporting capability of fibrin scaffold (FS), we evaluated the efficacy of a stem-cell therapy for EAL by engrafting a...

journal_title：Stem cells translational medicine

authors： Xue X,Yan Y,Ma Y,Yuan Y,Li C,Lang X,Xu Z,Chen H,Zhang H

更新日期：2019-06-01 00:00:00

abstract：:Organoids are three-dimensional culture systems in which adult stem cells and their progeny grow and represent the native physiology of the cells in vivo. Organoids have been successfully derived from several organ systems in both animal models and human patients. Organoids have been used for fundamental research, dis...

journal_title：Stem cells translational medicine

authors： Nantasanti S,de Bruin A,Rothuizen J,Penning LC,Schotanus BA

更新日期：2016-03-01 00:00:00