Concise Review: Organoids Are a Powerful Tool for the Study of Liver Disease and Personalized Treatment Design in Humans and Animals.

abstract：:Repair of injured lungs represents a longstanding therapeutic challenge. We recently demonstrated that human and mouse embryonic lung tissue from the canalicular stage of development are enriched with lung progenitors, and that a single cell suspension of canalicular lungs can be used for transplantation, provided tha...

journal_title：Stem cells translational medicine

authors： Milman Krentsis I,Rosen C,Shezen E,Aronovich A,Nathanson B,Bachar-Lustig E,Berkman N,Assayag M,Shakhar G,Feferman T,Orgad R,Reisner Y

更新日期：2018-01-01 00:00:00

abstract：:Human-induced pluripotent stem cells (hiPSCs)-based cell therapy holds promise for treating stress urinary incontinence (SUI). However, safety concerns, especially tumorgenic potential of residual undifferentiated cells in hiPSC derivatives, are major barriers for its clinical translation. An efficient, fast and clini...

journal_title：Stem cells translational medicine

authors： Li Y,Green M,Wen Y,Wei Y,Wani P,Wang Z,Reijo Pera R,Chen B

更新日期：2017-04-01 00:00:00

abstract：:Perivascular stem cells (PSCs) are the natural ancestors of mesenchymal stem cells (MSCs) and are the stem cells responsible for homeostasis and repair in vivo. Prospectively identified and isolated PSCs have demonstrated increased plasticity and osteogenic potential. Cells from the infrapatellar fat pad (IFP) have de...

journal_title：Stem cells translational medicine

authors： Hindle P,Khan N,Biant L,Péault B

更新日期：2017-01-01 00:00:00

abstract：:Osteoarthritic and other types of articular cartilage defects never heal on their own. Medicinal and surgical approaches are often ineffective, and the supply of autologous chondrocytes for tissue engineering is very limited. Bone marrow stromal cells (BMSCs, also known as bone marrow-derived mesenchymal stem cells) h...

journal_title：Stem cells translational medicine

authors： Kuznetsov SA,Hailu-Lazmi A,Cherman N,de Castro LF,Robey PG,Gorodetsky R

更新日期：2019-06-01 00:00:00

abstract：:For years, our ability to study pathological changes in neurological diseases has been hampered by the lack of relevant models until the recent groundbreaking work from Yamanaka's group showing that it is feasible to generate induced pluripotent stem cells (iPSCs) from human somatic cells and to redirect the fate of t...

journal_title：Stem cells translational medicine

authors： Badja C,Maleeva G,El-Yazidi C,Barruet E,Lasserre M,Tropel P,Binetruy B,Bregestovski P,Magdinier F

更新日期：2014-12-01 00:00:00

abstract：:The differentiation of human stem cells into insulin secreting beta-like cells holds great promise to treat diabetes. Current protocols drive stem cells through stages of directed differentiation and maturation and produce cells that secrete insulin in response to glucose. Further refinements are now needed to faithfu...

journal_title：Stem cells translational medicine

authors： Singh R,Cottle L,Loudovaris T,Xiao D,Yang P,Thomas HE,Kebede MA,Thorn P

更新日期：2020-11-04 00:00:00

abstract：:Hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) play key roles in the production of mature blood cells and in the biology and clinical outcomes of hematopoietic transplants. The numbers of these cells, however, are extremely low, particularly in umbilical cord blood (UCB); thus, ex vivo expan...

journal_title：Stem cells translational medicine

authors： Flores-Guzmán P,Fernández-Sánchez V,Mayani H

更新日期：2013-11-01 00:00:00

abstract：UNLABELLED:: Chronic rotator cuff (RC) tears are a common and debilitating injury, characterized by dramatic expansion of adipose tissue, muscle atrophy, and limited functional recovery. The role of adipose expansion in RC pathology is unknown; however, given the identified paracrine/endocrine regulation by other adipo...

journal_title：Stem cells translational medicine

authors： Meyer GA,Gibbons MC,Sato E,Lane JG,Ward SR,Engler AJ

更新日期：2015-07-01 00:00:00

abstract：:There is a need among patients suffering from drug-resistant epilepsy (DRE) for more efficient and less toxic treatments. The objective of the present study was to assess the safety, feasibility, and potential efficacy of autologous bone marrow cell transplantation in pediatric patients with DRE. Two females and two m...

journal_title：Stem cells translational medicine

authors： Milczarek O,Jarocha D,Starowicz-Filip A,Kwiatkowski S,Badyra B,Majka M

更新日期：2018-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are very attractive candidates in cell-based strategies that target inflammatory diseases. Preclinical animal studies and many clinical trials have demonstrated that human MSCs can be safely administered and that they modify the inflammatory process in the targeted injured tissue. Our lab...

journal_title：Stem cells translational medicine

authors： Waterman RS,Morgenweck J,Nossaman BD,Scandurro AE,Scandurro SA,Betancourt AM

更新日期：2012-07-01 00:00:00

abstract：:In the field of disease modeling, induced pluripotent stem cells (iPSCs) have become an appealing choice, especially for diseases that do not have an animal model. They can be generated from patients with known clinical features and compared with cells from healthy controls to identify the biological bases of disease....

journal_title：Stem cells translational medicine

authors： Vitale AM,Matigian NA,Ravishankar S,Bellette B,Wood SA,Wolvetang EJ,Mackay-Sim A

更新日期：2012-09-01 00:00:00

abstract：:Human induced pluripotent stem cells (hiPSCs) hold great potential for use in regenerative medicine, novel drug development, and disease progression/developmental studies. Here, we report highly efficient differentiation of hiPSCs toward a relatively homogeneous population of functional hepatocytes. hiPSC-derived hepa...

journal_title：Stem cells translational medicine

authors： Ma X,Duan Y,Tschudy-Seney B,Roll G,Behbahan IS,Ahuja TP,Tolstikov V,Wang C,McGee J,Khoobyari S,Nolta JA,Willenbring H,Zern MA

更新日期：2013-06-01 00:00:00

abstract：:Muscle-derived stem cells (MDSCs) isolated from mouse skeletal muscle by a modified preplate technique exhibit long-term proliferation, high self-renewal, and multipotent differentiation capabilities in vitro. MDSCs retrovirally transduced to express bone morphogenetic proteins (BMPs) can differentiate into osteocytes...

journal_title：Stem cells translational medicine

authors： Li H,Johnson NR,Usas A,Lu A,Poddar M,Wang Y,Huard J

更新日期：2013-09-01 00:00:00

abstract：:γδT cells constitute a small proportion of lymphocytes in peripheral blood. Unlike αβT cells, the anti-tumor activities are exerted through several different pathways in a MHC-unrestricted manner. Thus, immunotherapy using γδT cells is considered to be effective for various types of cancer. Occasionally, however, ex v...

journal_title：Stem cells translational medicine

authors： Watanabe D,Koyanagi-Aoi M,Taniguchi-Ikeda M,Yoshida Y,Azuma T,Aoi T

更新日期：2018-01-01 00:00:00

abstract：:Global cerebral ischemia (GCI) is the leading cause of a poor prognosis even after successful resuscitation from cardiac arrest. Therapeutic induction of hypothermia (TH) is the only proven therapy-and current standard care-for GCI after cardiac arrest; however, its application has been significantly limited owing to ...

journal_title：Stem cells translational medicine

authors： Chung TN,Kim JH,Choi BY,Chung SP,Kwon SW,Suh SW

更新日期：2015-02-01 00:00:00

abstract：:Steroid-induced osteonecrosis of the femoral head (ONFH) is characterized by decreased osteogenesis, angiogenesis, and increased adipogenesis. While bone tissue engineering has been widely investigated to treat ONFH, its therapeutic effects remain unsatisfactory. Therefore, further studies are required to determine op...

journal_title：Stem cells translational medicine

authors： Xu H,Wang C,Liu C,Peng Z,Li J,Jin Y,Wang Y,Guo J,Zhu L

更新日期：2021-01-13 00:00:00

abstract：:Lamin A (LMNA)-linked lipodystrophies may be either genetic (associated with LMNA mutations) or acquired (associated with the use of human immunodeficiency virus protease inhibitors [PIs]), and in both cases they share clinical features such as anomalous distribution of body fat or generalized loss of adipose tissue, ...

journal_title：Stem cells translational medicine

authors： Ruiz de Eguino G,Infante A,Schlangen K,Aransay AM,Fullaondo A,Soriano M,García-Verdugo JM,Martín AG,Rodríguez CI

更新日期：2012-04-01 00:00:00

abstract：:An important stage in the development of any new therapeutic agent is establishment of the optimal dosage and route of administration. This can be particularly challenging when the treatment is a biologic agent that might exert its therapeutic effects via complex or poorly understood mechanisms. Multiple preclinical a...

journal_title：Stem cells translational medicine

authors： Golpanian S,Schulman IH,Ebert RF,Heldman AW,DiFede DL,Yang PC,Wu JC,Bolli R,Perin EC,Moyé L,Simari RD,Wolf A,Hare JM,Cardiovascular Cell Therapy Research Network.

更新日期：2016-02-01 00:00:00

abstract：:: Phosphatase and tension homolog (PTEN) is a widely known negative regulator of insulin/phosphatidylinositol 3-kinase (PI3K) signaling. The PI3K/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) and Ras-extracellular signal-regulated kinase (Ras-ERK) signaling pathways are the chief mechanisms controlling the surviva...

journal_title：Stem cells translational medicine

authors： Lee JE,Lim MS,Park JH,Park CH,Koh HC

更新日期：2016-10-01 00:00:00

abstract：:Cancer stem cells (CSCs) are a subpopulation of tumor cells that have strong self-renewal capabilities and may contribute to the failure of conventional cancer therapies. Hence, therapeutics homing in on CSCs represent a novel and promising approach that may eradicate malignant tumors. However, the lack of information...

journal_title：Stem cells translational medicine

authors： Hu X,Cong Y,Luo HH,Wu S,Zhao LE,Liu Q,Yang Y

更新日期：2017-02-01 00:00:00

abstract：:The present first-in-human clinical trial evaluated the safety and feasibility of a newly developed and cryopreserved Cardiology Stem Cell Centre adipose-derived stromal cell (CSCC_ASC) product from healthy donors for intramyocardial injection in ten patients with ischemic heart disease and ischemic heart failure (IHF...

journal_title：Stem cells translational medicine

authors： Kastrup J,Haack-Sørensen M,Juhl M,Harary Søndergaard R,Follin B,Drozd Lund L,Mønsted Johansen E,Ali Qayyum A,Bruun Mathiasen A,Jørgensen E,Helqvist S,Jørgen Elberg J,Bruunsgaard H,Ekblond A

更新日期：2017-11-01 00:00:00

abstract：:Diabetes is a risk factor for worse outcomes following acute myocardial infarction (AMI). In this study, we tested the hypothesis that SDF-1:CXCR4 expression is compromised in post-AMI in diabetes, and that reversal of this defect can reverse the adverse effects of diabetes. Mesenchymal stem cells (MSC) isolated from ...

journal_title：Stem cells translational medicine

authors： Mayorga ME,Kiedrowski M,McCallinhart P,Forudi F,Ockunzzi J,Weber K,Chilian W,Penn MS,Dong F

更新日期：2018-01-01 00:00:00

abstract：:Mesenchymal stem cells (multipotent stromal cells; MSCs) have been under investigation for the treatment of diverse diseases, with many promising outcomes achieved in animal models and clinical trials. The biological activity of MSC therapies has not been fully resolved which is critical to rationalizing their use and...

journal_title：Stem cells translational medicine

authors： Stavely R,Nurgali K

更新日期：2020-09-01 00:00:00

abstract：:Patient-specific induced pluripotent stem cells (iPSCs) hold great promise for many applications, including disease modeling to elucidate mechanisms involved in disease pathogenesis, drug screening, and ultimately regenerative medicine therapies. A frequently used starting source of cells for reprogramming has been de...

journal_title：Stem cells translational medicine

authors： Barrett R,Ornelas L,Yeager N,Mandefro B,Sahabian A,Lenaeus L,Targan SR,Svendsen CN,Sareen D

更新日期：2014-12-01 00:00:00

abstract：:Heart diseases (HDs) are the leading cause of morbidity and mortality worldwide. Despite remarkable clinical progress made, current therapies cannot restore the lost myocardium, and the correlation of genotype to phenotype of many HDs is poorly modeled. In the past two decades, with the rapid developments of human plu...

journal_title：Stem cells translational medicine

authors： Li Q,Wang J,Wu Q,Cao N,Yang HT

更新日期：2020-10-01 00:00:00

abstract：:Cellular therapy is enabling new approaches to tackle significant unmet needs in areas such as regenerative medicine and immunotherapy. The pharmacology of cell therapeutics becomes of critical importance to assure that these new drugs work reproducibly and effectively. Cell pharmacology can benefit from adapting prin...

journal_title：Stem cells translational medicine

authors： Aijaz A,Vaninov N,Allen A,Barcia RN,Parekkadan B

更新日期：2019-09-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have been investigated as a clinical therapy to promote tissue repair. However, the disappearance of grafted cells soon after engraftment suggests a possible role as initiators of repair rather than effectors. We evaluated the relative contribution of grafted human MSCs and host stem/prog...

journal_title：Stem cells translational medicine

authors： Shin L,Peterson DA

更新日期：2013-01-01 00:00:00

abstract：:Adipose tissue-derived multipotent stromal cells (AT-MSCs) are studied as an alternative to bone marrow-derived multipotent stromal cells (BM-MSCs) for immunomodulatory treatment. In this study, we systematically compared the immunomodulatory capacities of BM-MSCs and AT-MSCs derived from age-matched donors. We found ...

journal_title：Stem cells translational medicine

authors： Melief SM,Zwaginga JJ,Fibbe WE,Roelofs H

更新日期：2013-06-01 00:00:00

abstract：:We conducted a phase II, noncomparative, multicenter study to assess the efficacy and safety of allogeneic bone marrow-derived mesenchymal stromal cells (BM-MSCs) expanded in vitro for patients with aplastic anemia (AA) refractory to immunosuppressive therapy. Seventy-four patients from seven centers received allogene...

journal_title：Stem cells translational medicine

authors： Pang Y,Xiao HW,Zhang H,Liu ZH,Li L,Gao Y,Li HB,Jiang ZJ,Tan H,Lin JR,Du X,Weng JY,Nie DN,Lin DJ,Zhang XZ,Liu QF,Xu DR,Chen HJ,Ge XH,Wang XY,Xiao Y

更新日期：2017-07-01 00:00:00

abstract：:Knee osteoarthritis (OA) is a leading cause of pain and disability. Although conventional treatments show modest benefits, pilot and phase I/II trials with bone marrow (BM) and adipose-derived (AD) mesenchymal stromal cells (MSCs) point to the feasibility, safety, and occurrence of clinical and structural improvement ...

journal_title：Stem cells translational medicine

authors： Matas J,Orrego M,Amenabar D,Infante C,Tapia-Limonchi R,Cadiz MI,Alcayaga-Miranda F,González PL,Muse E,Khoury M,Figueroa FE,Espinoza F

更新日期：2019-03-01 00:00:00