Abstract:
:Cancer stem cells play a critical role in disease initiation and insensitivity to chemotherapy in numerous hematologic malignancies and some solid tumors, and these stem cells need to be eradicated to achieve a cure. Key to successful targeting of cancer stem cells is to identify and functionally test critical target genes and to fully understand their associated molecular network in these stem cells. Human chronic myeloid leukemia (CML) is well accepted as one of the typical types of hematopoietic malignancies that are derived from leukemia stem cells (LSCs), serving as an excellent model disease for understanding the biology of LSCs and developing effective, selective, and curative strategies through targeting LSCs. Here, we discuss LSCs in CML with a focus on identification of unique biological features of these stem cells to emphasize the feasibility and significance of specific targeting of LSCs while sparing normal stem cell counterparts in leukemia therapy. Stem Cells Translational Medicine 2019;8:768&774.
journal_name
Stem Cells Transl Medjournal_title
Stem cells translational medicineauthors
Zhang H,Li Sdoi
10.1002/sctm.18-0247subject
Has Abstractpub_date
2019-08-01 00:00:00pages
768-774issue
8eissn
2157-6564issn
2157-6580journal_volume
8pub_type
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