A Human Corneal Epithelial Cell Line Model for Limbal Stem Cell Biology and Limbal Immunobiology.

abstract：UNLABELLED:The California Institute for Regenerative Medicine (CIRM) has invested approximately $70 million in programs targeting various orthopedic indications, including osteoporosis, bone fracture healing, vertebral compression fractures, and several others. The present article serves to outline the current state of...

journal_title：Stem cells translational medicine

authors： Littman N,Abo A

更新日期：2015-11-01 00:00:00

abstract：UNLABELLED:Human cord blood (CB)-derived hematopoietic stem cells (HSCs) are an interesting source for HSC transplantation. However, the number of collected CB-HSCs is often too low for one transplantation; therefore, ex vivo expansion of CB-HSCs is desirable. Current expansion protocols are based on the use of cytokin...

journal_title：Stem cells translational medicine

authors： Heinz N,Ehrnström B,Schambach A,Schwarzer A,Modlich U,Schiedlmeier B

更新日期：2015-09-01 00:00:00

abstract：:Although mesenchymal stromal cells (MSCs) possess immunomodulatory properties and exhibit promising efficacy against chronic graft-versus-host disease (cGVHD), little is known about the immune changes by which MSCs ameliorate cGVHD in vivo. Recent studies have suggested that B lymphocytes might play an important role ...

journal_title：Stem cells translational medicine

authors： Peng Y,Chen X,Liu Q,Xu D,Zheng H,Liu L,Liu Q,Liu M,Fan Z,Sun J,Li X,Zou R,Xiang AP

更新日期：2014-09-01 00:00:00

abstract：:Global cerebral ischemia (GCI) is the leading cause of a poor prognosis even after successful resuscitation from cardiac arrest. Therapeutic induction of hypothermia (TH) is the only proven therapy-and current standard care-for GCI after cardiac arrest; however, its application has been significantly limited owing to ...

journal_title：Stem cells translational medicine

authors： Chung TN,Kim JH,Choi BY,Chung SP,Kwon SW,Suh SW

更新日期：2015-02-01 00:00:00

abstract：UNLABELLED:Cell secretion is an important mechanism for stem cell-based therapeutic angiogenesis, along with cell differentiation to vascular endothelial cells or smooth muscle cells. Cell-released microvesicles (MVs) have been recently implicated to play an essential role in intercellular communication. The purpose of...

journal_title：Stem cells translational medicine

authors： Kang T,Jones TM,Naddell C,Bacanamwo M,Calvert JW,Thompson WE,Bond VC,Chen YE,Liu D

更新日期：2016-04-01 00:00:00

abstract：:Stem cell therapy is a promising strategy for tissue regeneration. The therapeutic benefits of cell therapy are mediated by both direct and indirect mechanisms. However, the application of stem cell therapy in the clinic is hampered by several limitations. This concise review provides a brief introduction into stem ce...

journal_title：Stem cells translational medicine

authors： Tang JN,Cores J,Huang K,Cui XL,Luo L,Zhang JY,Li TS,Qian L,Cheng K

更新日期：2018-04-01 00:00:00

abstract：:: Fast remyelination by endogenous oligodendrocyte precursor cells (OPCs) is essential to prevent axonal and subsequent retrograde neuronal degeneration in demyelinating lesions in multiple sclerosis (MS). In chronic lesions, however, the remyelination capacity of OPCs becomes insufficient. Cell therapy with exogenous...

journal_title：Stem cells translational medicine

authors： Thiruvalluvan A,Czepiel M,Kap YA,Mantingh-Otter I,Vainchtein I,Kuipers J,Bijlard M,Baron W,Giepmans B,Brück W,'t Hart BA,Boddeke E,Copray S

更新日期：2016-11-01 00:00:00

abstract：:Human pluripotent stem cells have the potential to promote biological studies and accelerate drug discovery efforts by making possible direct experimentation on a variety of human cell types of interest. However, stem cell cultures are generally heterogeneous and efficient differentiation and purification protocols ar...

journal_title：Stem cells translational medicine

authors： Sluch VM,Chamling X,Liu MM,Berlinicke CA,Cheng J,Mitchell KL,Welsbie DS,Zack DJ

更新日期：2017-11-01 00:00:00

abstract：:Adipose-derived stem cell (ADSC)-based therapy is promising for critical limb ischemia (CLI) treatment, especially in patients with diabetes. However, the therapeutic effects of diabetic ADSCs (D-ADSCs) are impaired by the diabetes, possibly through intracellular reactive oxygen species (ROS) accumulation. The objecti...

journal_title：Stem cells translational medicine

authors： Peng Z,Yang X,Qin J,Ye K,Wang X,Shi H,Jiang M,Liu X,Lu X

更新日期：2017-01-01 00:00:00

abstract：:The immunomodulatory activity of mesenchymal stem/stromal cells (MSCs) to suppress innate and adaptive immune responses offers a potent cell therapy for modulating inflammation and promoting tissue regeneration. However, the inflammatory cytokine milieu plays a critical role in stimulating MSC immunomodulatory activit...

journal_title：Stem cells translational medicine

authors： Zimmermann JA,Hettiaratchi MH,McDevitt TC

更新日期：2017-01-01 00:00:00

abstract：:The vascular wall stores mesenchymal progenitor cells which are able to induce bone regeneration, via direct and paracrine mechanisms. Although much is known regarding perivascular cell regulation of osteoblasts, their regulation of osteoclasts, and by extension utility in states of high bone resorption, is not known....

journal_title：Stem cells translational medicine

authors： Negri S,Wang Y,Sono T,Lee S,Hsu GC,Xu J,Meyers CA,Qin Q,Broderick K,Witwer KW,Peault B,James AW

更新日期：2020-12-01 00:00:00

abstract：:Development of efficient and reproducible conditions for directed differentiation of pluripotent stem cells into specific cell types is important not only to understand early human development but also to enable more practical applications, such as in vitro disease modeling, drug discovery, and cell therapies. The dif...

journal_title：Stem cells translational medicine

authors： Choudhary P,Booth H,Gutteridge A,Surmacz B,Louca I,Steer J,Kerby J,Whiting PJ

更新日期：2017-02-01 00:00:00

abstract：:Bone marrow mesenchymal stem cells (BMSCs) have been shown to offer a wide variety of cellular functions including the protective effects on damaged hearts. Here we investigated the antiaging properties of BMSCs and the underlying mechanism in a cellular model of cardiomyocyte senescence and a rat model of aging heart...

journal_title：Stem cells translational medicine

authors： Zhang M,Liu D,Li S,Chang L,Zhang Y,Liu R,Sun F,Duan W,Du W,Wu Y,Zhao T,Xu C,Lu Y

更新日期：2015-05-01 00:00:00

abstract：:Osteoarthritic and other types of articular cartilage defects never heal on their own. Medicinal and surgical approaches are often ineffective, and the supply of autologous chondrocytes for tissue engineering is very limited. Bone marrow stromal cells (BMSCs, also known as bone marrow-derived mesenchymal stem cells) h...

journal_title：Stem cells translational medicine

authors： Kuznetsov SA,Hailu-Lazmi A,Cherman N,de Castro LF,Robey PG,Gorodetsky R

更新日期：2019-06-01 00:00:00

abstract：:Lamin A (LMNA)-linked lipodystrophies may be either genetic (associated with LMNA mutations) or acquired (associated with the use of human immunodeficiency virus protease inhibitors [PIs]), and in both cases they share clinical features such as anomalous distribution of body fat or generalized loss of adipose tissue, ...

journal_title：Stem cells translational medicine

authors： Ruiz de Eguino G,Infante A,Schlangen K,Aransay AM,Fullaondo A,Soriano M,García-Verdugo JM,Martín AG,Rodríguez CI

更新日期：2012-04-01 00:00:00

abstract：:Organoids are three-dimensional culture systems in which adult stem cells and their progeny grow and represent the native physiology of the cells in vivo. Organoids have been successfully derived from several organ systems in both animal models and human patients. Organoids have been used for fundamental research, dis...

journal_title：Stem cells translational medicine

authors： Nantasanti S,de Bruin A,Rothuizen J,Penning LC,Schotanus BA

更新日期：2016-03-01 00:00:00

abstract：UNLABELLED:: Recapitulation of endochondral ossification (ECO) (i.e., generation of marrow-containing ossicles through a cartilage intermediate) has relevance to develop human organotypic models for bone or hematopoietic cells and to engineer grafts for bone regeneration. Unlike bone marrow-derived stromal cells (also ...

journal_title：Stem cells translational medicine

authors： Osinga R,Di Maggio N,Todorov A,Allafi N,Barbero A,Laurent F,Schaefer DJ,Martin I,Scherberich A

更新日期：2016-08-01 00:00:00

abstract：:We conducted a phase II, noncomparative, multicenter study to assess the efficacy and safety of allogeneic bone marrow-derived mesenchymal stromal cells (BM-MSCs) expanded in vitro for patients with aplastic anemia (AA) refractory to immunosuppressive therapy. Seventy-four patients from seven centers received allogene...

journal_title：Stem cells translational medicine

authors： Pang Y,Xiao HW,Zhang H,Liu ZH,Li L,Gao Y,Li HB,Jiang ZJ,Tan H,Lin JR,Du X,Weng JY,Nie DN,Lin DJ,Zhang XZ,Liu QF,Xu DR,Chen HJ,Ge XH,Wang XY,Xiao Y

更新日期：2017-07-01 00:00:00

abstract：:: Paracrine signaling by bone-marrow-derived mesenchymal stem cells (MSCs) plays a major role in tissue repair. Although the production of regulatory cytokines by MSC transplantation is a critical modulator of tissue regeneration, we focused on exosomes, which are extracellular vesicles that contain proteins and nucle...

journal_title：Stem cells translational medicine

authors： Furuta T,Miyaki S,Ishitobi H,Ogura T,Kato Y,Kamei N,Miyado K,Higashi Y,Ochi M

更新日期：2016-12-01 00:00:00

abstract：:Acute respiratory distress syndrome (ARDS) in COVID-19 is associated with high mortality. Mesenchymal stem cells are known to exert immunomodulatory and anti-inflammatory effects and could yield beneficial effects in COVID-19 ARDS. The objective of this study was to determine safety and explore efficacy of umbilical c...

journal_title：Stem cells translational medicine

authors： Lanzoni G,Linetsky E,Correa D,Messinger Cayetano S,Alvarez RA,Kouroupis D,Alvarez Gil A,Poggioli R,Ruiz P,Marttos AC,Hirani K,Bell CA,Kusack H,Rafkin L,Baidal D,Pastewski A,Gawri K,Leñero C,Mantero AMA,Metalonis SW

更新日期：2021-01-05 00:00:00

abstract：:Device-encapsulated human stem cell-derived pancreatic endoderm (PE) can generate functional β-cell implants in the subcutis of mice, which has led to the start of clinical studies in type 1 diabetes. Assessment of the formed functional β-cell mass (FBM) and its correlation with in vivo metabolic markers can guide cli...

journal_title：Stem cells translational medicine

authors： Robert T,De Mesmaeker I,Van Hulle FO,Suenens KG,Stangé GM,Ling Z,Haller C,Bouche N,Keymeulen B,Kraus MRC,Pipeleers DG

更新日期：2019-12-01 00:00:00

abstract：:Stem cells have been widely used in tendon tissue engineering. The lack of refined and controlled differentiation strategy hampers the tendon repair and regeneration. This study aimed to find new effective differentiation factors for stepwise tenogenic differentiation. By microarray screening, the transcript factor Fo...

journal_title：Stem cells translational medicine

authors： Chen J,Zhang E,Zhang W,Liu Z,Lu P,Zhu T,Yin Z,Backman LJ,Liu H,Chen X,Ouyang H

更新日期：2017-11-01 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) offer an effective platform for studies of human physiology and have revealed new possibilities for disease modeling at the cellular level. These cells also have the potential to be leveraged in the practice of precision medicine, including personalized drug testing. Aortic disea...

journal_title：Stem cells translational medicine

authors： Zhu K,Ma W,Li J,Zhang YS,Zhang W,Lai H,Wang C

更新日期：2021-02-01 00:00:00

abstract：:Cancer stem cells (CSCs) are a subpopulation of tumor cells that have strong self-renewal capabilities and may contribute to the failure of conventional cancer therapies. Hence, therapeutics homing in on CSCs represent a novel and promising approach that may eradicate malignant tumors. However, the lack of information...

journal_title：Stem cells translational medicine

authors： Hu X,Cong Y,Luo HH,Wu S,Zhao LE,Liu Q,Yang Y

更新日期：2017-02-01 00:00:00

abstract：:Knee osteoarthritis (OA) is a leading cause of pain and disability. Although conventional treatments show modest benefits, pilot and phase I/II trials with bone marrow (BM) and adipose-derived (AD) mesenchymal stromal cells (MSCs) point to the feasibility, safety, and occurrence of clinical and structural improvement ...

journal_title：Stem cells translational medicine

authors： Matas J,Orrego M,Amenabar D,Infante C,Tapia-Limonchi R,Cadiz MI,Alcayaga-Miranda F,González PL,Muse E,Khoury M,Figueroa FE,Espinoza F

更新日期：2019-03-01 00:00:00

abstract：:Muscle-derived stem cells (MDSCs) isolated from mouse skeletal muscle by a modified preplate technique exhibit long-term proliferation, high self-renewal, and multipotent differentiation capabilities in vitro. MDSCs retrovirally transduced to express bone morphogenetic proteins (BMPs) can differentiate into osteocytes...

journal_title：Stem cells translational medicine

authors： Li H,Johnson NR,Usas A,Lu A,Poddar M,Wang Y,Huard J

更新日期：2013-09-01 00:00:00

abstract：UNLABELLED:We evaluated the association of diabetes and insulin resistance with the response to cell therapy in patients with nonischemic dilated cardiomyopathy (DCM). A total of 45 outpatients with DCM received granulocyte colony-stimulating factor for 5 days. CD34(+) cells were then collected by apheresis and injecte...

journal_title：Stem cells translational medicine

authors： Vrtovec B,Sever M,Jensterle M,Poglajen G,Janez A,Kravos N,Zemljic G,Cukjati M,Cernelc P,Haddad F,Wu JC,Jorde UP

更新日期：2016-05-01 00:00:00

abstract：:An understanding of how cancer cells adapt dormancy would allow for targeted treatment. The current literature suggests that the cancer stem cells might be the major cells with the ability to become quiescent and to resist current drug treatment. The properties of cancer stem cells and healthy stem cells are functiona...

journal_title：Stem cells translational medicine

authors： Bliss SA,Greco SJ,Rameshwar P

更新日期：2014-07-01 00:00:00

abstract：:Studies of human cerebral cortex development are limited by difficulties in accessing and manipulating human neural tissue at specific development stages. We have derived human radial glia (hRG), which are responsible for most cerebral cortex neurogenesis, from human pluripotent stem cells. These hRG display the hallm...

journal_title：Stem cells translational medicine

authors： Duan L,Peng CY,Pan L,Kessler JA

更新日期：2015-05-01 00:00:00

abstract：:Patient-specific induced pluripotent stem cells (iPSCs) hold great promise for studies on disease-related developmental processes and may serve as an autologous cell source for future treatment of many hereditary diseases. New genetic engineering tools such as zinc finger nucleases and transcription activator-like eff...

journal_title：Stem cells translational medicine

authors： Eggenschwiler R,Loya K,Wu G,Sharma AD,Sgodda M,Zychlinski D,Herr C,Steinemann D,Teckman J,Bals R,Ott M,Schambach A,Schöler HR,Cantz T

更新日期：2013-09-01 00:00:00