Concise review: next-generation cell therapies to prevent infections in neutropenic patients.

Abstract:

:High-dose chemotherapy is accompanied by an obligate period of neutropenia. Resulting bacterial and fungal infections are the leading cause of morbidity and mortality in neutropenic patients despite prophylactic antimicrobials and hematopoietic growth factor supplements. Replacing neutrophils in the patient through transfusion of donor cells is a logical solution to prevent fulminant infections. In the past, this strategy has been hampered by poor yield, inability to store collected cells, and possible donor morbidity caused by granulocyte colony-stimulating factor injections and apheresis. Today, neutrophil-like cells can be manufactured in the laboratory at the clinical scale from hematopoietic stem and progenitor cells enriched from umbilical cord blood. This article reviews the rationale for focusing research efforts toward ex vivo neutrophil production and explores clinical settings for future trials.

journal_name

Stem Cells Transl Med

authors

Brunck ME,Nielsen LK

doi

10.5966/sctm.2013-0145

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

541-8

issue

4

eissn

2157-6564

issn

2157-6580

pii

sctm.2013-0145

journal_volume

3

pub_type

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