Abstract:
:Preterm birth and its complications are the leading cause of neonatal death. The main underlying pathological mechanisms for preterm complications are disruption of the normal maturation processes within the target tissues, interrupted by premature birth. Cord blood, as a new and convenient source of stem cells, may provide new, promising options for preventing preterm complications. This prospective, nonrandomized placebo controlled study aimed at investigating the effect of autologous cord blood mononuclear cells (ACBMNC) for preventing preterm associated complications. Preterm infants less than 35 weeks gestational age were assigned to receive ACBMNC (5 × 107 cells/kg) intravenous or normal saline within 8 hours after birth. Preterm complication rates were compared between two groups to demonstrate the effect of ACBMNC infusion in reducing preterm complications. Fifteen preterm infants received ACBMNC infusion, and 16 infants were assigned to the control group. There were no significant differences when comparing mortality and preterm complication rates before discharge. However, ACBMNC infusion demonstrated significant decreases in duration of mechanical ventilation (3.2 days vs 6.41 days, P = .028) and oxygen therapy (5.33 days vs 11.31 days, P = .047). ACBMNC infusion was effective in reducing respiratory support duration in very preterm infants. Due to the limited number of patients enrolled, powered randomized controlled trials are needed to better define its efficacy.
journal_name
Stem Cells Transl Medjournal_title
Stem cells translational medicineauthors
Ren Z,Xu F,Zhang X,Zhang C,Miao J,Xia X,Kang M,Wei W,Ma T,Zhang Q,Lu L,Wen J,Liu G,Liu K,Wang Q,Yang Jdoi
10.1002/sctm.19-0106subject
Has Abstractpub_date
2020-02-01 00:00:00pages
169-176issue
2eissn
2157-6564issn
2157-6580journal_volume
9pub_type
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