Enhanced structure and function of human pluripotent stem cell-derived beta-cells cultured on extracellular matrix.

abstract：:Similar to the disease affecting humans, osteoarthritis (OA) is a painful musculoskeletal condition affecting 20% of the adult canine population. Several solutions have been proposed, but the results achieved to date are far from being satisfactory. New approaches, such as intra-articular delivery of cells (including ...

journal_title：Stem cells translational medicine

authors： Zeira O,Scaccia S,Pettinari L,Ghezzi E,Asiag N,Martinelli L,Zahirpour D,Dumas MP,Konar M,Lupi DM,Fiette L,Pascucci L,Leonardi L,Cliff A,Alessandri G,Pessina A,Spaziante D,Aralla M

更新日期：2018-11-01 00:00:00

abstract：:Improved therapeutic assessment of experimental traumatic brain injury (TBI), using mesenchymal stem cells (MSCs), would immensely benefit its therapeutic management. Neurometabolite patterns at injury site, measured with proton magnetic resonance spectroscopy (1H-MRS) after MSCs transplantation, may serve as a bio-in...

journal_title：Stem cells translational medicine

authors： Mishra SK,Rana P,Khushu S,Gangenahalli G

更新日期：2017-01-01 00:00:00

abstract：:: Paracrine signaling by bone-marrow-derived mesenchymal stem cells (MSCs) plays a major role in tissue repair. Although the production of regulatory cytokines by MSC transplantation is a critical modulator of tissue regeneration, we focused on exosomes, which are extracellular vesicles that contain proteins and nucle...

journal_title：Stem cells translational medicine

authors： Furuta T,Miyaki S,Ishitobi H,Ogura T,Kato Y,Kamei N,Miyado K,Higashi Y,Ochi M

更新日期：2016-12-01 00:00:00

abstract：:Muscle-derived stem cells (MDSCs) isolated from mouse skeletal muscle by a modified preplate technique exhibit long-term proliferation, high self-renewal, and multipotent differentiation capabilities in vitro. MDSCs retrovirally transduced to express bone morphogenetic proteins (BMPs) can differentiate into osteocytes...

journal_title：Stem cells translational medicine

authors： Li H,Johnson NR,Usas A,Lu A,Poddar M,Wang Y,Huard J

更新日期：2013-09-01 00:00:00

abstract：:To optimize the regenerative proficiency of stem cells, a cardiopoietic protein-based cocktail consisting of multiple growth factors has been developed and advanced into clinical trials for treatment of ischemic heart failure. Streamlining the inductors of cardiopoiesis would address the resource intensive nature of t...

journal_title：Stem cells translational medicine

authors： Li M,Yamada S,Shi A,Singh RD,Rolland TJ,Jeon R,Lopez N,Shelerud L,Terzic A,Behfar A

更新日期：2020-10-24 00:00:00

abstract：:Human pluripotent stem cells have the potential to promote biological studies and accelerate drug discovery efforts by making possible direct experimentation on a variety of human cell types of interest. However, stem cell cultures are generally heterogeneous and efficient differentiation and purification protocols ar...

journal_title：Stem cells translational medicine

authors： Sluch VM,Chamling X,Liu MM,Berlinicke CA,Cheng J,Mitchell KL,Welsbie DS,Zack DJ

更新日期：2017-11-01 00:00:00

abstract：:The present first-in-human clinical trial evaluated the safety and feasibility of a newly developed and cryopreserved Cardiology Stem Cell Centre adipose-derived stromal cell (CSCC_ASC) product from healthy donors for intramyocardial injection in ten patients with ischemic heart disease and ischemic heart failure (IHF...

journal_title：Stem cells translational medicine

authors： Kastrup J,Haack-Sørensen M,Juhl M,Harary Søndergaard R,Follin B,Drozd Lund L,Mønsted Johansen E,Ali Qayyum A,Bruun Mathiasen A,Jørgensen E,Helqvist S,Jørgen Elberg J,Bruunsgaard H,Ekblond A

更新日期：2017-11-01 00:00:00

abstract：:Accumulating evidence indicates that stem cells (SCs) possess immunomodulatory, anti-inflammatory, and prohealing properties. The mechanisms underlying these functions are being investigated with the final goal to set a solid background for the clinical use of SCs and/or their derivatives. Specialized proresolving lip...

journal_title：Stem cells translational medicine

authors： Romano M,Patruno S,Pomilio A,Recchiuti A

更新日期：2019-10-01 00:00:00

abstract：:Development of efficient and reproducible conditions for directed differentiation of pluripotent stem cells into specific cell types is important not only to understand early human development but also to enable more practical applications, such as in vitro disease modeling, drug discovery, and cell therapies. The dif...

journal_title：Stem cells translational medicine

authors： Choudhary P,Booth H,Gutteridge A,Surmacz B,Louca I,Steer J,Kerby J,Whiting PJ

更新日期：2017-02-01 00:00:00

abstract：:Gaucher disease (GD) is the most common lysosomal storage disease resulting from mutations in the lysosomal enzyme glucocerebrosidase (GCase). The hematopoietic abnormalities in GD include the presence of characteristic Gaucher macrophages that infiltrate patient tissues and cytopenias. At present, it is not clear whe...

journal_title：Stem cells translational medicine

authors： Sgambato JA,Park TS,Miller D,Panicker LM,Sidransky E,Lun Y,Awad O,Bentzen SM,Zambidis ET,Feldman RA

更新日期：2015-08-01 00:00:00

abstract：:Long-term lentiviral transduction of human mesenchymal stem cells (hMSCs) greatly enhances the usefulness of these cells. However, such transduction currently requires the use of polybrene, which severely inhibits hMSC proliferation. In contrast, protamine sulfate at 100 μg/ml doubled transduction efficiencies without...

journal_title：Stem cells translational medicine

authors： Lin P,Lin Y,Lennon DP,Correa D,Schluchter M,Caplan AI

更新日期：2012-12-01 00:00:00

abstract：:Human induced pluripotent stem cells (hiPSCs) hold great potential for use in regenerative medicine, novel drug development, and disease progression/developmental studies. Here, we report highly efficient differentiation of hiPSCs toward a relatively homogeneous population of functional hepatocytes. hiPSC-derived hepa...

journal_title：Stem cells translational medicine

authors： Ma X,Duan Y,Tschudy-Seney B,Roll G,Behbahan IS,Ahuja TP,Tolstikov V,Wang C,McGee J,Khoobyari S,Nolta JA,Willenbring H,Zern MA

更新日期：2013-06-01 00:00:00

abstract：UNLABELLED:: Induced pluripotent stem cells (iPSCs) are new diagnostic and potentially therapeutic tools to model disease and assess the toxicity of pharmaceutical medications. A common limitation of cell lineages derived from iPSCs is a blunted phenotype compared with fully developed, endogenous cells. We examined the...

journal_title：Stem cells translational medicine

authors： Wang B,Jakus AE,Baptista PM,Soker S,Soto-Gutierrez A,Abecassis MM,Shah RN,Wertheim JA

更新日期：2016-09-01 00:00:00

abstract：:The potential plasticity and therapeutic utility in tissue regeneration of human adipose-derived stem cells (ASCs) isolated from adult adipose tissue have recently been highlighted. The use of autologous platelet-rich plasma (PRP) represents an alternative strategy in regenerative medicine for the local release of mul...

journal_title：Stem cells translational medicine

authors： Cervelli V,Scioli MG,Gentile P,Doldo E,Bonanno E,Spagnoli LG,Orlandi A

更新日期：2012-03-01 00:00:00

abstract：:Despite approaches in regenerative medicine using stem cells, bio-engineered scaffolds, and targeted drug delivery to enhance human tissue repair, clinicians remain unable to regenerate large-scale, multi-tissue defects in situ. The study of regenerative biology using mammalian models of complex tissue regeneration of...

journal_title：Stem cells translational medicine

authors： Simkin J,Seifert AW

更新日期：2018-02-01 00:00:00

abstract：UNLABELLED:The oral cavity possesses a diverse microflora, yet recurrent infections within healthy individuals are rare. Wound healing within the buccal mucosa is preferential, potentially because of the presence of oral mucosal lamina propria-progenitor cells (OMLP-PCs). In addition to their multipotency, OMLP-PCs dem...

journal_title：Stem cells translational medicine

authors： Board-Davies E,Moses R,Sloan A,Stephens P,Davies LC

更新日期：2015-11-01 00:00:00

abstract：:In initial work, we developed a 14-day culture protocol under potential GMP, chemically defined conditions to generate chondroprogenitors from human embryonic stem cells (hESCs). The present study was undertaken to investigate the cartilage repair capacity of these cells. The chondrogenic protocol was optimized and va...

journal_title：Stem cells translational medicine

authors： Cheng A,Kapacee Z,Peng J,Lu S,Lucas RJ,Hardingham TE,Kimber SJ

更新日期：2014-11-01 00:00:00

abstract：:Vascular changes, including blood brain barrier destabilization, are common pathological features in multiple sclerosis (MS) lesions. Blood vessels within adult organs are reported to harbor mesenchymal stromal cells (MSCs) with phenotypical and functional characteristics similar to pericytes. We performed an immunohi...

journal_title：Stem cells translational medicine

authors： Iacobaeus E,Sugars RV,Törnqvist Andrén A,Alm JJ,Qian H,Frantzen J,Newcombe J,Alkass K,Druid H,Bottai M,Röyttä M,Le Blanc K

更新日期：2017-10-01 00:00:00

abstract：UNLABELLED:The California Institute for Regenerative Medicine (CIRM) has invested approximately $70 million in programs targeting various orthopedic indications, including osteoporosis, bone fracture healing, vertebral compression fractures, and several others. The present article serves to outline the current state of...

journal_title：Stem cells translational medicine

authors： Littman N,Abo A

更新日期：2015-11-01 00:00:00

abstract：:Steroid-induced osteonecrosis of the femoral head (ONFH) is characterized by decreased osteogenesis, angiogenesis, and increased adipogenesis. While bone tissue engineering has been widely investigated to treat ONFH, its therapeutic effects remain unsatisfactory. Therefore, further studies are required to determine op...

journal_title：Stem cells translational medicine

authors： Xu H,Wang C,Liu C,Peng Z,Li J,Jin Y,Wang Y,Guo J,Zhu L

更新日期：2021-01-13 00:00:00

abstract：:: Liver fibrosis represents the end stage of chronic liver inflammatory diseases and is defined by the abnormal accumulation of extracellular matrix in the liver. Advanced liver fibrosis results in cirrhosis, liver failure, and portal hypertension. Liver transplantation has been the most effective treatment for these ...

journal_title：Stem cells translational medicine

authors： Lee PH,Tu CT,Hsiao CC,Tsai MS,Ho CM,Cheng NC,Hung TM,Shih DT

更新日期：2016-11-01 00:00:00

abstract：:Diabetes engenders the loss of pancreatic β-cell mass and/or function, resulting in insulin deficiency relative to the metabolic needs of the body. Diabetic care has traditionally relied on pharmacotherapy, exemplified by insulin replacement to target peripheral actions of the hormone. With growing understanding of th...

journal_title：Stem cells translational medicine

authors： Holditch SJ,Terzic A,Ikeda Y

更新日期：2014-05-01 00:00:00

abstract：:Knee osteoarthritis (OA) is a leading cause of pain and disability. Although conventional treatments show modest benefits, pilot and phase I/II trials with bone marrow (BM) and adipose-derived (AD) mesenchymal stromal cells (MSCs) point to the feasibility, safety, and occurrence of clinical and structural improvement ...

journal_title：Stem cells translational medicine

authors： Matas J,Orrego M,Amenabar D,Infante C,Tapia-Limonchi R,Cadiz MI,Alcayaga-Miranda F,González PL,Muse E,Khoury M,Figueroa FE,Espinoza F

更新日期：2019-03-01 00:00:00

abstract：:γδT cells constitute a small proportion of lymphocytes in peripheral blood. Unlike αβT cells, the anti-tumor activities are exerted through several different pathways in a MHC-unrestricted manner. Thus, immunotherapy using γδT cells is considered to be effective for various types of cancer. Occasionally, however, ex v...

journal_title：Stem cells translational medicine

authors： Watanabe D,Koyanagi-Aoi M,Taniguchi-Ikeda M,Yoshida Y,Azuma T,Aoi T

更新日期：2018-01-01 00:00:00

abstract：:Hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) play key roles in the production of mature blood cells and in the biology and clinical outcomes of hematopoietic transplants. The numbers of these cells, however, are extremely low, particularly in umbilical cord blood (UCB); thus, ex vivo expan...

journal_title：Stem cells translational medicine

authors： Flores-Guzmán P,Fernández-Sánchez V,Mayani H

更新日期：2013-11-01 00:00:00

abstract：:We conducted a phase II, noncomparative, multicenter study to assess the efficacy and safety of allogeneic bone marrow-derived mesenchymal stromal cells (BM-MSCs) expanded in vitro for patients with aplastic anemia (AA) refractory to immunosuppressive therapy. Seventy-four patients from seven centers received allogene...

journal_title：Stem cells translational medicine

authors： Pang Y,Xiao HW,Zhang H,Liu ZH,Li L,Gao Y,Li HB,Jiang ZJ,Tan H,Lin JR,Du X,Weng JY,Nie DN,Lin DJ,Zhang XZ,Liu QF,Xu DR,Chen HJ,Ge XH,Wang XY,Xiao Y

更新日期：2017-07-01 00:00:00

abstract：:Animal models show that systemically administered bone marrow-derived mesenchymal stem cells (MSCs) home to sites of primary and metastatic prostate cancer (PC)-making them candidates to selectively deliver cytotoxic agents. To further assess this potential as a cell-based therapeutic vehicle, a phase I study testing ...

journal_title：Stem cells translational medicine

authors： Schweizer MT,Wang H,Bivalacqua TJ,Partin AW,Lim SJ,Chapman C,Abdallah R,Levy O,Bhowmick NA,Karp JM,De Marzo A,Isaacs JT,Brennen WN,Denmeade SR

更新日期：2019-05-01 00:00:00

abstract：:The kidney is a specialized low-regenerative organ with several different types of cellular lineages; however, the identity of renal stem/progenitor cells with nephrogenic potential and their preferred niche(s) are largely unknown and debated. Most of the therapeutic approaches to kidney regeneration are based on admi...

journal_title：Stem cells translational medicine

authors： Aggarwal S,Moggio A,Bussolati B

更新日期：2013-12-01 00:00:00

abstract：UNLABELLED:: Present therapies for stroke rest with tissue plasminogen activator (tPA), the sole licensed antithrombotic on the market; however, tPA's effectiveness is limited in that the drug not only must be administered less than 3-5 hours after stroke but often exacerbates blood-brain barrier (BBB) leakage and incr...

journal_title：Stem cells translational medicine

authors： Eckert A,Huang L,Gonzalez R,Kim HS,Hamblin MH,Lee JP

更新日期：2015-07-01 00:00:00

abstract：UNLABELLED:Cell secretion is an important mechanism for stem cell-based therapeutic angiogenesis, along with cell differentiation to vascular endothelial cells or smooth muscle cells. Cell-released microvesicles (MVs) have been recently implicated to play an essential role in intercellular communication. The purpose of...

journal_title：Stem cells translational medicine

authors： Kang T,Jones TM,Naddell C,Bacanamwo M,Calvert JW,Thompson WE,Bond VC,Chen YE,Liu D

更新日期：2016-04-01 00:00:00