Efficient lentiviral transduction of human mesenchymal stem cells that preserves proliferation and differentiation capabilities.

abstract：:The immunomodulatory activity of mesenchymal stem/stromal cells (MSCs) to suppress innate and adaptive immune responses offers a potent cell therapy for modulating inflammation and promoting tissue regeneration. However, the inflammatory cytokine milieu plays a critical role in stimulating MSC immunomodulatory activit...

journal_title：Stem cells translational medicine

authors： Zimmermann JA,Hettiaratchi MH,McDevitt TC

更新日期：2017-01-01 00:00:00

abstract：:Improved therapeutic assessment of experimental traumatic brain injury (TBI), using mesenchymal stem cells (MSCs), would immensely benefit its therapeutic management. Neurometabolite patterns at injury site, measured with proton magnetic resonance spectroscopy (1H-MRS) after MSCs transplantation, may serve as a bio-in...

journal_title：Stem cells translational medicine

authors： Mishra SK,Rana P,Khushu S,Gangenahalli G

更新日期：2017-01-01 00:00:00

abstract：:The kidney is a specialized low-regenerative organ with several different types of cellular lineages; however, the identity of renal stem/progenitor cells with nephrogenic potential and their preferred niche(s) are largely unknown and debated. Most of the therapeutic approaches to kidney regeneration are based on admi...

journal_title：Stem cells translational medicine

authors： Aggarwal S,Moggio A,Bussolati B

更新日期：2013-12-01 00:00:00

abstract：:The differentiation of human stem cells into insulin secreting beta-like cells holds great promise to treat diabetes. Current protocols drive stem cells through stages of directed differentiation and maturation and produce cells that secrete insulin in response to glucose. Further refinements are now needed to faithfu...

journal_title：Stem cells translational medicine

authors： Singh R,Cottle L,Loudovaris T,Xiao D,Yang P,Thomas HE,Kebede MA,Thorn P

更新日期：2020-11-04 00:00:00

abstract：:Recent reports have indicated human embryonic stem cells-derived midbrain dopamine (mDA) neurons as proper cell resources for use in Parkinson's disease (PD) therapy. Nevertheless, no detailed and systematic study has been conducted to identify which differentiation stages of mDA cells are most suitable for transplant...

journal_title：Stem cells translational medicine

authors： Qiu L,Liao MC,Chen AK,Wei S,Xie S,Reuveny S,Zhou ZD,Hunziker W,Tan EK,Oh SKW,Zeng L

更新日期：2017-09-01 00:00:00

abstract：:Chromaffin cells, sympathetic neurons of the dorsal ganglia, and the intermediate small intensely fluorescent cells derive from a common neural crest progenitor cell. Contrary to the closely related sympathetic nervous system, within the adult adrenal medulla a subpopulation of undifferentiated progenitor cells persis...

journal_title：Stem cells translational medicine

authors： Santana MM,Chung KF,Vukicevic V,Rosmaninho-Salgado J,Kanczkowski W,Cortez V,Hackmann K,Bastos CA,Mota A,Schrock E,Bornstein SR,Cavadas C,Ehrhart-Bornstein M

更新日期：2012-11-01 00:00:00

abstract：:Diabetes is a major global health issue and the number of individuals with type 1 diabetes (T1D) and type 2 diabetes (T2D) increases annually across multiple populations. Research to develop a cure must overcome multiple immune dysfunctions and the shortage of pancreatic islet β cells, but these challenges have proven...

journal_title：Stem cells translational medicine

authors： Zhao Y,Jiang Z,Delgado E,Li H,Zhou H,Hu W,Perez-Basterrechea M,Janostakova A,Tan Q,Wang J,Mao M,Yin Z,Zhang Y,Li Y,Li Q,Zhou J,Li Y,Martinez Revuelta E,Maria García-Gala J,Wang H,Perez-Lopez S,Alvarez-Viejo M,

更新日期：2017-08-01 00:00:00

abstract：:Limbal stem cell (LSC) deficiency is a visually debilitating condition caused by abnormal maintenance of LSCs. It is treated by transplantation of donor-derived limbal epithelial cells (LECs), the success of which depends on the presence and quality of LSCs within the transplant. Understanding the immunobiological res...

journal_title：Stem cells translational medicine

authors： Shaharuddin B,Ahmad S,Md Latar N,Ali S,Meeson A

更新日期：2017-03-01 00:00:00

abstract：:Heart diseases (HDs) are the leading cause of morbidity and mortality worldwide. Despite remarkable clinical progress made, current therapies cannot restore the lost myocardium, and the correlation of genotype to phenotype of many HDs is poorly modeled. In the past two decades, with the rapid developments of human plu...

journal_title：Stem cells translational medicine

authors： Li Q,Wang J,Wu Q,Cao N,Yang HT

更新日期：2020-10-01 00:00:00

abstract：:Diabetes is a risk factor for worse outcomes following acute myocardial infarction (AMI). In this study, we tested the hypothesis that SDF-1:CXCR4 expression is compromised in post-AMI in diabetes, and that reversal of this defect can reverse the adverse effects of diabetes. Mesenchymal stem cells (MSC) isolated from ...

journal_title：Stem cells translational medicine

authors： Mayorga ME,Kiedrowski M,McCallinhart P,Forudi F,Ockunzzi J,Weber K,Chilian W,Penn MS,Dong F

更新日期：2018-01-01 00:00:00

abstract：:High-dose chemotherapy is accompanied by an obligate period of neutropenia. Resulting bacterial and fungal infections are the leading cause of morbidity and mortality in neutropenic patients despite prophylactic antimicrobials and hematopoietic growth factor supplements. Replacing neutrophils in the patient through tr...

journal_title：Stem cells translational medicine

authors： Brunck ME,Nielsen LK

更新日期：2014-04-01 00:00:00

abstract：:Unfortunately, many patients referred for hematopoietic cell transplant will not have a fully matched related donor, and finding matched unrelated donors through the registry may be difficult, especially if the recipient is not of Northern European descent [N Engl J Med 2014;371:339-348]. Umbilical cord blood (UCB) ha...

journal_title：Stem cells translational medicine

authors： Kindwall-Keller TL,Ballen KK

更新日期：2020-10-01 00:00:00

abstract：UNLABELLED:Histone deacetylase (HDAC) inhibitors possess therapeutic potential to reverse aberrant epigenetic changes associated with cancers, neurological diseases, and immune disorders. Unfortunately, clinical studies with some HDAC inhibitors displayed delayed cardiac adverse effects, such as atrial fibrillation and...

journal_title：Stem cells translational medicine

authors： Kopljar I,Gallacher DJ,De Bondt A,Cougnaud L,Vlaminckx E,Van den Wyngaert I,Lu HR

更新日期：2016-05-01 00:00:00

abstract：:Niemann-Pick disease, type C1 (NPC1) is a familial disorder that has devastating consequences on postnatal development with multisystem effects, including neurodegeneration. There is no Food and Drug Administration-approved treatment option for NPC1; however, several potentially therapeutic compounds have been identif...

journal_title：Stem cells translational medicine

authors： Efthymiou AG,Steiner J,Pavan WJ,Wincovitch S,Larson DM,Porter FD,Rao MS,Malik N

更新日期：2015-03-01 00:00:00

abstract：UNLABELLED:Rotator cuff tendon tear is one of the most common causes of chronic shoulder pain and disability. In this study, we investigated the therapeutic effects of ultrasound-guided human umbilical cord blood (UCB)-derived mesenchymal stem cell (MSC) injection to regenerate a full-thickness subscapularis tendon tea...

journal_title：Stem cells translational medicine

authors： Park GY,Kwon DR,Lee SC

更新日期：2015-11-01 00:00:00

abstract：:Diabetes engenders the loss of pancreatic β-cell mass and/or function, resulting in insulin deficiency relative to the metabolic needs of the body. Diabetic care has traditionally relied on pharmacotherapy, exemplified by insulin replacement to target peripheral actions of the hormone. With growing understanding of th...

journal_title：Stem cells translational medicine

authors： Holditch SJ,Terzic A,Ikeda Y

更新日期：2014-05-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have immunomodulatory properties and support hematopoiesis in the bone marrow (BM). To develop a new strategy not only to prevent graft-vs-host disease (GVHD) but also enhance engraftment, a phase I trial of cord blood transplantation (CBT) combined with intra-BM injection of MSCs (MSC-CB...

journal_title：Stem cells translational medicine

authors： Goto T,Murata M,Nishida T,Terakura S,Kamoshita S,Ishikawa Y,Ushijima Y,Adachi Y,Suzuki S,Kato K,Hirakawa A,Nishiwaki S,Nishio N,Takahashi Y,Kodera Y,Matsushita T,Kiyoi H

更新日期：2020-12-14 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) have elicited excitement in both the scientific and ethics communities for their potential to advance basic and translational research. They have been hailed as an alternative to derivation from embryos that provides a virtually unlimited source of pluripotent stem cells for rese...

journal_title：Stem cells translational medicine

authors： Lowenthal J,Lipnick S,Rao M,Hull SC

更新日期：2012-05-01 00:00:00

abstract：UNLABELLED:: Chronic rotator cuff (RC) tears are a common and debilitating injury, characterized by dramatic expansion of adipose tissue, muscle atrophy, and limited functional recovery. The role of adipose expansion in RC pathology is unknown; however, given the identified paracrine/endocrine regulation by other adipo...

journal_title：Stem cells translational medicine

authors： Meyer GA,Gibbons MC,Sato E,Lane JG,Ward SR,Engler AJ

更新日期：2015-07-01 00:00:00

abstract：:Adult hemoglobin composed of α- and β-globin reflects a change from expression of embryonic ε- and fetal γ-globin to adult β-globin in human erythroid cells, so-called globin switching. Human pluripotent stem cells (hPSCs) are a potential source for in vitro erythrocyte production, but they show prominent expression o...

journal_title：Stem cells translational medicine

authors： Ochi K,Takayama N,Hirose S,Nakahata T,Nakauchi H,Eto K

更新日期：2014-07-01 00:00:00

abstract：:Stem cells have been widely used in tendon tissue engineering. The lack of refined and controlled differentiation strategy hampers the tendon repair and regeneration. This study aimed to find new effective differentiation factors for stepwise tenogenic differentiation. By microarray screening, the transcript factor Fo...

journal_title：Stem cells translational medicine

authors： Chen J,Zhang E,Zhang W,Liu Z,Lu P,Zhu T,Yin Z,Backman LJ,Liu H,Chen X,Ouyang H

更新日期：2017-11-01 00:00:00

abstract：:Gaucher disease (GD) is the most common lysosomal storage disease resulting from mutations in the lysosomal enzyme glucocerebrosidase (GCase). The hematopoietic abnormalities in GD include the presence of characteristic Gaucher macrophages that infiltrate patient tissues and cytopenias. At present, it is not clear whe...

journal_title：Stem cells translational medicine

authors： Sgambato JA,Park TS,Miller D,Panicker LM,Sidransky E,Lun Y,Awad O,Bentzen SM,Zambidis ET,Feldman RA

更新日期：2015-08-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are very attractive candidates in cell-based strategies that target inflammatory diseases. Preclinical animal studies and many clinical trials have demonstrated that human MSCs can be safely administered and that they modify the inflammatory process in the targeted injured tissue. Our lab...

journal_title：Stem cells translational medicine

authors： Waterman RS,Morgenweck J,Nossaman BD,Scandurro AE,Scandurro SA,Betancourt AM

更新日期：2012-07-01 00:00:00

abstract：:: Paracrine signaling by bone-marrow-derived mesenchymal stem cells (MSCs) plays a major role in tissue repair. Although the production of regulatory cytokines by MSC transplantation is a critical modulator of tissue regeneration, we focused on exosomes, which are extracellular vesicles that contain proteins and nucle...

journal_title：Stem cells translational medicine

authors： Furuta T,Miyaki S,Ishitobi H,Ogura T,Kato Y,Kamei N,Miyado K,Higashi Y,Ochi M

更新日期：2016-12-01 00:00:00

abstract：:Adipose-derived stem cells (ASCs) are being tested in clinical trials related to cell-based regenerative therapies. Although most of the current expansion protocols for ASCs use fetal calf serum (FCS), xenogeneic-free medium supplements are greatly desired. This study aims to compare the effect of FCS, human platelet ...

journal_title：Stem cells translational medicine

authors： Riis S,Nielsen FM,Pennisi CP,Zachar V,Fink T

更新日期：2016-03-01 00:00:00

abstract：:Breast cancer-related lymphedema (BCRL) is a debilitating late complication with a lack of treatment opportunities. Recent studies have suggested that mesenchymal stromal cells can alleviate lymphedema. Herein, we report the results from the first human pilot study with freshly isolated adipose-derived regenerative ce...

journal_title：Stem cells translational medicine

authors： Toyserkani NM,Jensen CH,Andersen DC,Sheikh SP,Sørensen JA

更新日期：2017-08-01 00:00:00

abstract：:: Phosphatase and tension homolog (PTEN) is a widely known negative regulator of insulin/phosphatidylinositol 3-kinase (PI3K) signaling. The PI3K/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) and Ras-extracellular signal-regulated kinase (Ras-ERK) signaling pathways are the chief mechanisms controlling the surviva...

journal_title：Stem cells translational medicine

authors： Lee JE,Lim MS,Park JH,Park CH,Koh HC

更新日期：2016-10-01 00:00:00

abstract：:Cellular therapy is enabling new approaches to tackle significant unmet needs in areas such as regenerative medicine and immunotherapy. The pharmacology of cell therapeutics becomes of critical importance to assure that these new drugs work reproducibly and effectively. Cell pharmacology can benefit from adapting prin...

journal_title：Stem cells translational medicine

authors： Aijaz A,Vaninov N,Allen A,Barcia RN,Parekkadan B

更新日期：2019-09-01 00:00:00

abstract：:Steroid-induced osteonecrosis of the femoral head (ONFH) is characterized by decreased osteogenesis, angiogenesis, and increased adipogenesis. While bone tissue engineering has been widely investigated to treat ONFH, its therapeutic effects remain unsatisfactory. Therefore, further studies are required to determine op...

journal_title：Stem cells translational medicine

authors： Xu H,Wang C,Liu C,Peng Z,Li J,Jin Y,Wang Y,Guo J,Zhu L

更新日期：2021-01-13 00:00:00

abstract：:For years, our ability to study pathological changes in neurological diseases has been hampered by the lack of relevant models until the recent groundbreaking work from Yamanaka's group showing that it is feasible to generate induced pluripotent stem cells (iPSCs) from human somatic cells and to redirect the fate of t...

journal_title：Stem cells translational medicine

authors： Badja C,Maleeva G,El-Yazidi C,Barruet E,Lasserre M,Tropel P,Binetruy B,Bregestovski P,Magdinier F

更新日期：2014-12-01 00:00:00