Efficient and cost-effective generation of mature neurons from human induced pluripotent stem cells.

abstract：:Mesenchymal stem cells (MSCs) can be isolated from bone marrow or other adult tissues (adipose tissue, dental pulp, amniotic fluid, and umbilical cord). In vitro, MSCs grow as adherent cells, display fibroblast-like morphology, and self-renew, undergoing specific mesodermal differentiation. High heterogeneity of MSCs ...

journal_title：Stem cells translational medicine

authors： Bajetto A,Thellung S,Dellacasagrande I,Pagano A,Barbieri F,Florio T

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Tendon or ligament tears can decrease patients' quality of life. Many therapeutic interventions are available to treat such injuries. Mesenchymal stem cells (MSCs) have been shown to be effective in treating tendon or ligament tears; however, the use of stem cell-conditioned medium (CM) requires further inve...

journal_title：Stem cells translational medicine

authors： Rhatomy S,Prasetyo TE,Setyawan R,Soekarno NR,Romaniyanto F,Sedjati AP,Sumarwoto T,Utomo DN,Suroto H,Mahyudin F,Prakoeswa CRS

更新日期：2020-08-01 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) offer an effective platform for studies of human physiology and have revealed new possibilities for disease modeling at the cellular level. These cells also have the potential to be leveraged in the practice of precision medicine, including personalized drug testing. Aortic disea...

journal_title：Stem cells translational medicine

authors： Zhu K,Ma W,Li J,Zhang YS,Zhang W,Lai H,Wang C

更新日期：2021-02-01 00:00:00

abstract：UNLABELLED:: Present therapies for stroke rest with tissue plasminogen activator (tPA), the sole licensed antithrombotic on the market; however, tPA's effectiveness is limited in that the drug not only must be administered less than 3-5 hours after stroke but often exacerbates blood-brain barrier (BBB) leakage and incr...

journal_title：Stem cells translational medicine

authors： Eckert A,Huang L,Gonzalez R,Kim HS,Hamblin MH,Lee JP

更新日期：2015-07-01 00:00:00

abstract：:In initial work, we developed a 14-day culture protocol under potential GMP, chemically defined conditions to generate chondroprogenitors from human embryonic stem cells (hESCs). The present study was undertaken to investigate the cartilage repair capacity of these cells. The chondrogenic protocol was optimized and va...

journal_title：Stem cells translational medicine

authors： Cheng A,Kapacee Z,Peng J,Lu S,Lucas RJ,Hardingham TE,Kimber SJ

更新日期：2014-11-01 00:00:00

abstract：:Steroid-induced osteonecrosis of the femoral head (ONFH) is characterized by decreased osteogenesis, angiogenesis, and increased adipogenesis. While bone tissue engineering has been widely investigated to treat ONFH, its therapeutic effects remain unsatisfactory. Therefore, further studies are required to determine op...

journal_title：Stem cells translational medicine

authors： Xu H,Wang C,Liu C,Peng Z,Li J,Jin Y,Wang Y,Guo J,Zhu L

更新日期：2021-01-13 00:00:00

abstract：:High-dose chemotherapy is accompanied by an obligate period of neutropenia. Resulting bacterial and fungal infections are the leading cause of morbidity and mortality in neutropenic patients despite prophylactic antimicrobials and hematopoietic growth factor supplements. Replacing neutrophils in the patient through tr...

journal_title：Stem cells translational medicine

authors： Brunck ME,Nielsen LK

更新日期：2014-04-01 00:00:00

abstract：UNLABELLED:Duchenne muscular dystrophy (DMD), caused by mutations in the dystrophin gene, is the most common muscular dystrophy. Characterized by rounds of muscle degeneration and regeneration, DMD features progressive muscle wasting and is fatal. One approach for treatment is transplantation of muscle progenitor cells...

journal_title：Stem cells translational medicine

authors： Lala-Tabbert N,Fu D,Wiper-Bergeron N

更新日期：2016-04-01 00:00:00

abstract：:Owing to the rapid progress in stem cell research (SCR) and regenerative medicine (RM), society's expectation and interest in these fields are increasing. For effective communication on issues concerning SCR and RM, surveys for understanding the interests of stakeholders is essential. For this purpose, we conducted a ...

journal_title：Stem cells translational medicine

authors： Shineha R,Inoue Y,Ikka T,Kishimoto A,Yashiro Y

更新日期：2018-02-01 00:00:00

abstract：:The specific cell surface markers on mesenchymal stem/progenitor cells (MSCs) have been poorly defined in vivo, but in one recent study, an MSC subpopulation was directly isolated from a CD271-positive fraction of human bone marrow cells. The aim of this study was to identify circulating CD271(+) MSCs in human periphe...

journal_title：Stem cells translational medicine

authors： Iso Y,Yamaya S,Sato T,Poole CN,Isoyama K,Mimura M,Koba S,Kobayashi Y,Takeyama Y,Spees JL,Suzuki H

更新日期：2012-06-01 00:00:00

abstract：:Stem cells are promising candidate cells for regenerative applications because they possess high proliferative capacity and the potential to differentiate into other cell types. Mesenchymal stem cells (MSCs) are easily sourced but do not retain their proliferative and multilineage differentiative capabilities after pr...

journal_title：Stem cells translational medicine

authors： Boyette LB,Creasey OA,Guzik L,Lozito T,Tuan RS

更新日期：2014-02-01 00:00:00

abstract：:Tissue regeneration using progenitor cell-based therapy has the potential to aid in the healing of a diverse range of pathologies, ranging from short-gut syndrome to spinal cord lesions. However, there are numerous hurdles to be overcome prior to the widespread application of these cells in the clinical setting. One o...

journal_title：Stem cells translational medicine

authors： Hyun J,Grova M,Nejadnik H,Lo D,Morrison S,Montoro D,Chung M,Zimmermann A,Walmsley GG,Lee M,Daldrup-Link H,Wan DC,Longaker MT

更新日期：2013-09-01 00:00:00

abstract：:Device-encapsulated human stem cell-derived pancreatic endoderm (PE) can generate functional β-cell implants in the subcutis of mice, which has led to the start of clinical studies in type 1 diabetes. Assessment of the formed functional β-cell mass (FBM) and its correlation with in vivo metabolic markers can guide cli...

journal_title：Stem cells translational medicine

authors： Robert T,De Mesmaeker I,Van Hulle FO,Suenens KG,Stangé GM,Ling Z,Haller C,Bouche N,Keymeulen B,Kraus MRC,Pipeleers DG

更新日期：2019-12-01 00:00:00

abstract：:Niemann-Pick disease, type C1 (NPC1) is a familial disorder that has devastating consequences on postnatal development with multisystem effects, including neurodegeneration. There is no Food and Drug Administration-approved treatment option for NPC1; however, several potentially therapeutic compounds have been identif...

journal_title：Stem cells translational medicine

authors： Efthymiou AG,Steiner J,Pavan WJ,Wincovitch S,Larson DM,Porter FD,Rao MS,Malik N

更新日期：2015-03-01 00:00:00

abstract：:Extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) have emerged as a promising form of regenerative therapy and immune modulation. Fundamental advances in our understanding of MSCs and EVs have allowed these fields to merge and create potential cell-free therapy options that are cell-based. EVs...

journal_title：Stem cells translational medicine

authors： Allan D,Tieu A,Lalu M,Burger D

更新日期：2020-01-01 00:00:00

abstract：:Diabetes engenders the loss of pancreatic β-cell mass and/or function, resulting in insulin deficiency relative to the metabolic needs of the body. Diabetic care has traditionally relied on pharmacotherapy, exemplified by insulin replacement to target peripheral actions of the hormone. With growing understanding of th...

journal_title：Stem cells translational medicine

authors： Holditch SJ,Terzic A,Ikeda Y

更新日期：2014-05-01 00:00:00

abstract：:Peripheral nerve injury presents significant therapeutic challenges for recovery of motor and sensory function in patients. Different clinical approaches exist but to date there has been no consensus on the most effective method of treatment. Here, we investigate a novel approach to peripheral nerve repair using olfac...

journal_title：Stem cells translational medicine

authors： Roche P,Alekseeva T,Widaa A,Ryan A,Matsiko A,Walsh M,Duffy GP,O'Brien FJ

更新日期：2017-10-01 00:00:00

abstract：:The development of a California-based induced pluripotent stem cell (iPSC) bank based on human leukocyte antigen (HLA) haplotype matching represents a significant challenge and a valuable opportunity for the advancement of regenerative medicine. However, previously published models of iPSC banks have neither addressed...

journal_title：Stem cells translational medicine

authors： Pappas DJ,Gourraud PA,Le Gall C,Laurent J,Trounson A,DeWitt N,Talib S

更新日期：2015-05-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have immunomodulatory properties and support hematopoiesis in the bone marrow (BM). To develop a new strategy not only to prevent graft-vs-host disease (GVHD) but also enhance engraftment, a phase I trial of cord blood transplantation (CBT) combined with intra-BM injection of MSCs (MSC-CB...

journal_title：Stem cells translational medicine

authors： Goto T,Murata M,Nishida T,Terakura S,Kamoshita S,Ishikawa Y,Ushijima Y,Adachi Y,Suzuki S,Kato K,Hirakawa A,Nishiwaki S,Nishio N,Takahashi Y,Kodera Y,Matsushita T,Kiyoi H

更新日期：2020-12-14 00:00:00

abstract：:Breast cancer-related lymphedema (BCRL) is a debilitating late complication with a lack of treatment opportunities. Recent studies have suggested that mesenchymal stromal cells can alleviate lymphedema. Herein, we report the results from the first human pilot study with freshly isolated adipose-derived regenerative ce...

journal_title：Stem cells translational medicine

authors： Toyserkani NM,Jensen CH,Andersen DC,Sheikh SP,Sørensen JA

更新日期：2017-08-01 00:00:00

abstract：:Development of efficient and reproducible conditions for directed differentiation of pluripotent stem cells into specific cell types is important not only to understand early human development but also to enable more practical applications, such as in vitro disease modeling, drug discovery, and cell therapies. The dif...

journal_title：Stem cells translational medicine

authors： Choudhary P,Booth H,Gutteridge A,Surmacz B,Louca I,Steer J,Kerby J,Whiting PJ

更新日期：2017-02-01 00:00:00

abstract：:: Phosphatase and tension homolog (PTEN) is a widely known negative regulator of insulin/phosphatidylinositol 3-kinase (PI3K) signaling. The PI3K/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) and Ras-extracellular signal-regulated kinase (Ras-ERK) signaling pathways are the chief mechanisms controlling the surviva...

journal_title：Stem cells translational medicine

authors： Lee JE,Lim MS,Park JH,Park CH,Koh HC

更新日期：2016-10-01 00:00:00

abstract：:Strategies for musculoskeletal tissue regeneration apply adult mesenchymal stem/stromal cells (MSCs) that can be sourced from bone marrow- and lipo-aspirates. Adipose tissue-derived MSCs are more easily harvested in the large quantities required for skeletal tissue-engineering approaches, but are generally considered ...

journal_title：Stem cells translational medicine

authors： Samsonraj RM,Dudakovic A,Manzar B,Sen B,Dietz AB,Cool SM,Rubin J,van Wijnen AJ

更新日期：2018-02-01 00:00:00

abstract：:The kidney is a specialized low-regenerative organ with several different types of cellular lineages; however, the identity of renal stem/progenitor cells with nephrogenic potential and their preferred niche(s) are largely unknown and debated. Most of the therapeutic approaches to kidney regeneration are based on admi...

journal_title：Stem cells translational medicine

authors： Aggarwal S,Moggio A,Bussolati B

更新日期：2013-12-01 00:00:00

abstract：:: Fast remyelination by endogenous oligodendrocyte precursor cells (OPCs) is essential to prevent axonal and subsequent retrograde neuronal degeneration in demyelinating lesions in multiple sclerosis (MS). In chronic lesions, however, the remyelination capacity of OPCs becomes insufficient. Cell therapy with exogenous...

journal_title：Stem cells translational medicine

authors： Thiruvalluvan A,Czepiel M,Kap YA,Mantingh-Otter I,Vainchtein I,Kuipers J,Bijlard M,Baron W,Giepmans B,Brück W,'t Hart BA,Boddeke E,Copray S

更新日期：2016-11-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are emerging as a promising therapeutic approach of cell-based therapy for a wide range of autoimmune disorders and degenerative diseases. In preclinical and clinical studies, MSCs have been shown to be highly efficient in treating graft-versus-host disease, systemic lupus erythematosus, ...

journal_title：Stem cells translational medicine

authors： Ren G,Chen X,Dong F,Li W,Ren X,Zhang Y,Shi Y

更新日期：2012-01-01 00:00:00

abstract：:Patient-specific induced pluripotent stem cells (iPSCs) hold great promise for studies on disease-related developmental processes and may serve as an autologous cell source for future treatment of many hereditary diseases. New genetic engineering tools such as zinc finger nucleases and transcription activator-like eff...

journal_title：Stem cells translational medicine

authors： Eggenschwiler R,Loya K,Wu G,Sharma AD,Sgodda M,Zychlinski D,Herr C,Steinemann D,Teckman J,Bals R,Ott M,Schambach A,Schöler HR,Cantz T

更新日期：2013-09-01 00:00:00

abstract：:Adipose-derived stem cells (ASCs) are being tested in clinical trials related to cell-based regenerative therapies. Although most of the current expansion protocols for ASCs use fetal calf serum (FCS), xenogeneic-free medium supplements are greatly desired. This study aims to compare the effect of FCS, human platelet ...

journal_title：Stem cells translational medicine

authors： Riis S,Nielsen FM,Pennisi CP,Zachar V,Fink T

更新日期：2016-03-01 00:00:00

abstract：:Limbal stem cell (LSC) deficiency is a visually debilitating condition caused by abnormal maintenance of LSCs. It is treated by transplantation of donor-derived limbal epithelial cells (LECs), the success of which depends on the presence and quality of LSCs within the transplant. Understanding the immunobiological res...

journal_title：Stem cells translational medicine

authors： Shaharuddin B,Ahmad S,Md Latar N,Ali S,Meeson A

更新日期：2017-03-01 00:00:00

abstract：:Lamin A (LMNA)-linked lipodystrophies may be either genetic (associated with LMNA mutations) or acquired (associated with the use of human immunodeficiency virus protease inhibitors [PIs]), and in both cases they share clinical features such as anomalous distribution of body fat or generalized loss of adipose tissue, ...

journal_title：Stem cells translational medicine

authors： Ruiz de Eguino G,Infante A,Schlangen K,Aransay AM,Fullaondo A,Soriano M,García-Verdugo JM,Martín AG,Rodríguez CI

更新日期：2012-04-01 00:00:00